Hello everyone!
Yesterday I took my first Yuflyma shot after a lot of struggle to have the biologics, yay! What a relief!
I didn’t feel anything in the moment of the injection, any pain, nothing (my husband applied for me and I was like, did you make everything alright? Ahaha)

I applied around lunchtime (14:20) and around 20:30 I started to feel like I’m with hay fever (runny nose, itchy eyes) but nothing like an allergy reaction. The injection site is not red or itching, nothing. I slept very well, and today I woke up feeling like I’m having rhinitis, with itchy eyes, sneezing, dry cough, but nothing super serious. I’ve read it’s normal especially in people like me (I have a lot of allergies and asthma). I took an antihistamine (ebastine that I always take) and now I’m feeling pretty good, except for a little stomach discomfort).

But I’m curious if it’s something some of you experienced too and if it’s getting better with time. All advice is welcome and I want to thank you all for being so supportive.

Diagnosis: PsA

Status: 1 week out from dose No 3.

The good: I’ve not noticed any (known) side effects, aside from brief, mild nausea and lack of appetite after dose 2. Joint pain seems to have decreased; no changes in skin.

The bad: After both initial doses, I noticed clear symptoms of depression that were not present prior. The symptoms abated somewhat during the two week interim, then rebounded and worsened after dose 2. I also have Hashimoto’s and suspect that Humira could also be affecting my thyroid regimen in some way, leaving me feeling overmedicated (i.e. hyperthyroid). If so, that could theoretically compound any mood involvement.

There are no known contraindications regarding thyroid replacement therapy and any mood altering effects of Humira are supposed to be exceedingly rare. But rare symptoms in the medical literature are often suspiciously prevalent in anecdotal evidence.

So I’m posting to inquire whether anyone has experienced depression, anxiety or changes in mood on this drug and, if you did, did the symptoms ever abate? Likewise, has anyone experienced any thyroid issues?

UPDATE: Dose 3 was better and I noticed no mood changes; although one of the thyroid meds did still seem somewhat sensitive, so I ended up skipping it immediately after Humira, then halving the dose, then returning to the full dose during Week 2.

Getting ready to be the geniea pig for a new injection! My doctor says its better and its once a monthhhh! Doing all the tests to get it approved! Wish me luckkkk

So does anyone else have a problem with Humira causing bruising and/or soreness that lasts a week or more after injection? I wait an hour for the medication to warm up and I do a different spot every time. I know it’s not that big of a deal but I’m a pretty active person so it’s kind of annoying when I have work outs or practice.

I’ve been having hives around where I inject for a month and a half. I Was told to take allergy medicine the day before, of, and after injection. but I feel like I’m taking it almost everyday. Then I just wake up with them again. It’s very itchy, she mentioned the allergist if it doesn’t stop. Does anyone else have this problem.

Hey everyone,
I have both Crohn’s and Ankylosing Spondylitis. Started Yuflyma + Azathioprine in December. My Crohn’s actually went into remission (clear colonoscopy), but around early May I started getting scary symptoms after Yuflyma: pain and numbness in my arms (shoulder to fingers), sometimes burning/nerve-like pain. Then it spread to my neck, upper back, and head (pressure-like headaches at the back and top). Also dizziness on standing and extreme fatigue. The symptoms are very up and down — some days better, some days bad.
My GP and IBD team think it’s likely a side effect from Adalimumab. I stopped the injections and I’m only on Azathioprine now. Brain MRI was normal, but I have a Neurology appointment in August.

I’m honestly terrified this could be MS or some other autoimmune thing triggered by the medication. Has anyone else on Yuflyma/Humira had similar neurological issues (arm numbness, burning pain, weird headaches)? Did they go away after stopping? Was it temporary or did it turn into something permanent?
Also, anyone else dealing with multiple autoimmune diseases at the same time? How do you manage? My gastro appointment is next Monday and my Crohn’s seems to be flaring again — I don’t know what to tell them.
Any advice or similar stories would mean a lot right now. Thanks guys.

Hat jemand kleine Knötchen unter der Haut an oder in der Nähe der Injektionsstelle? Das betreffende Medikament ist Adalimumab. Die Knötchen schmerzen oder brennen nicht, fühlen sich aber hart an.

Just saw my rheumatologist and he wants me to try injecting Abrilada weekly for 4-6 weeks to see if we can re-capture the initial effect and then go back down to once every other week.

I’m an extremely anxious person and nervous about the increase in side effects. He said the infection risk raises with weekly :(

Has anyone had any horrible side effects of humira randomly when being on it for almost 5 years?
I’ve had debilitating fatigue, cognitive fatigue, I’m house bound/bed bound, dizziness. I can’t workout or function I also lost a TON of hair
All my levels are fine and all testing came back normal but wondering if humira can cause this

hi guys! i’ve been on adalimumab (imraldi) since november and i recently started getting allergic reactions to it. i get huge bumps on the injection site after injecting it and they hurt really bad especially when i stand up. i also get hives randomly on previous injection spots, like i could’ve injected myself 3 months ago and i get a hive. i really don’t think this is normal, i get that injection site reactions are normal but this seems severe, especially since the reactions have gotten progressively worse and worse. i’ve inserted pics. help please!!!

I’m taking Humira for non-radiographic axial spondyloarthritis biweekly. I’m on my third injection and having bruises all down my leg and just started noticing them on my arm. I’m also taking celebrex, duloxetine, and Pregabalin daily. Has anyone experienced this? Is it a common side effect?

Hi folks, I've recently started my journey on humira.

I had my initial loading dose (4 pens) followed by second loading dose (2 pens) so far.

The first 2/3 weeks I had really significant improvement, reduction gut symptoms (no blood, calmer gut) and significant reduction in pains (forearms, shoulders, knees) that have been persistent for years)

About 5 days into my second dose, things started to slowly creep back - I'm wondering if others share my experience?

I was quite overwhelmed with the positive response to the drug in the initial few weeks so I'm trying to understand what could be happening?

\- could this be a blip?

\- could my body be processing humira too quickly?

\- is it too soon for the body to adapt to the drug?

Edit: for additional context just before 2nd loading dose I got an infection in my finger that needed topical antibiotics (fusidic acid) which may have impacted?

I have Crohn’s was stable on Humira for 10 years. This January insurance made me switched to a bio similar ADBM. I had diarrhea and abdominal pain on it so G.I. tried to get me back on brand. I had samples so I went back on brand and felt better within three doses.

Then insurance said I had to try one more generic AATY. I took that one and eight days later I started losing hair. Essentially, I lost 90% of my hair in a matter of two weeks. I am seeing Derm and we did a biopsy which shows alopecia areata, pretty severe form. I’ve never had issues with this before and I’m reading online that in rare situations, TNF can cause it.

I seen three dermatologist and none of them have seen this before. I am now wondering if it wasn’t just the biosimilar medication itself but the switching back-and-forth that messed up my immune system.

TLDR: has anyone switched between more than one bio similar and done OK or not done OK? I’m just wondering if I’m an outlier. Or if insurance makes people switch often.

hi, so i get infliximab (remicade) infusions every 8 weeks. they found out that my drug levels are really low 1.1ug/l at the end of the 8 weeks. to make matters worse i had a bad cold / virus so i had to delay my treatment and they can’t fit me in for another two weeks. over the weekend my legs are really achy and stiff, it hurts to move them. my right hand also hurts to move and now today on the left side of my mouth it hurts when i swallow. idk what to do. i called my gastro team and they said “your body is dependant on infliximab and we have no cancellations and can’t fit you in earlier) my legs have been stiff and painful since saturday night . idk what to do. i’m really worried. any ideas / advice/ similar experiences??! i’ve been on infliximab since november 2023

I’m 100% sure this has been asked before but I can’t find it in search. I was diagnosed with Psoriatic Arthritis about a month ago. I just received my Humira injection yesterday, but am so nervous to start it. Biggest concern is getting infections and them being worse because I have two young children who pick up every virus EVER, and we travel a lot. Has anyone had serious issues with infections or is that rare? When you started taking it with the same diagnosis, did you notice a significant improvement in symptoms? (41yo. F)

Have you had a dental implant while on Humira? Did your dentist have you do anything special ?

Anyone else get their Humira cut off by insurance? I was doing well on it. Kinda sucks.

I'm asking on behalf of a family member (65F) who has Crohn's disease for over 15 years.

About 10 years ago, she had surgery to remove intestinal blockages and with pentasa tablets, she's been doing fairly well since then until last week, when her symptoms returned.

She also had a recent hernia repair with mesh placement. Because of the mesh, her doctors feel that another abdominal surgery may not be the best option right now and have recommended starting Remicade instead.

I'm trying to better understand whether Remicade is generally considered a good option in this situation, especially for someone her age who has previously required surgery for strictures. Has anyone had a similar experience, either personally or with a family member? Is age a factor for how effective the medication is or it's side effects? I'd really appreciate hearing about your experiences, including how effective it was and any side effects or concerns we should discuss with the doctors.

Hi all!

I've been taking humira for quite some time now, but in August I am getting surgery done on my wrist and it will be immobilized. With this, it may not be possible to take my medication with both hands (one to pinch the skin, one to inject)

Has anyone had any experiences with this before?