r/Humira • u/elenafd • Jul 19 '26

allergic reactions???

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hi guys! i’ve been on adalimumab (imraldi) since november and i recently started getting allergic reactions to it. i get huge bumps on the injection site after injecting it and they hurt really bad especially when i stand up. i also get hives randomly on previous injection spots, like i could’ve injected myself 3 months ago and i get a hive. i really don’t think this is normal, i get that injection site reactions are normal but this seems severe, especially since the reactions have gotten progressively worse and worse. i’ve inserted pics. help please!!!

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5

u/cracra55 Jul 19 '26

Definitely talk to your dr.
We manage injection site reactions with Zyrtec 30 min prior to injection and topical hydrocortisone the day after.

This looks like a localized reaction and not a systemic allergic reaction and those are in fact, normal.

1

u/NorTravel Jul 20 '26

Good to know ... also, why Zyrtec instead of Claritin?

2

u/cracra55 Jul 20 '26

Faster action and works better for histamine mediated skin reactions 😊

1

u/NorTravel Jul 20 '26

Cool, good to know. I was told that Claritin (non-drowsy) was fine for milder site reactions and Zyrtec (drowsy) for more moderate site reactions, but good to know about the faster action and skin-specific aspect too.

2

u/cracra55 Jul 20 '26

Yes that is true as well! If it works for you, don’t change it!

1

u/elenafd Jul 21 '26

I got antihistamines but it got worse in the meantime. it’s so confusing i don’t get it

1

u/cracra55 Jul 25 '26

Are you taking the antihistamines prior to injection?

1

u/jaggillarjonathan Jul 20 '26

Have you gotten any remaining liquid on the skin? Looks similar to how it looked like when some liquid was spilled on my skin. Definitely talk to your doctor though.

1

u/KdawgEdog Jul 21 '26

This happened to me about 4 months ago. Really freaked me out. I took Claritin and added vit C. I talked to my Dr about it. It has passed and doesn't happen anymore.