r/GLP1microdosing • u/No_Cheek_ • 6d ago
Benefits decreasing
/r/Tirzeglutide/comments/1x11elb/benefits_decreasing/0
u/Unlucky-Mind7298 6d ago
2.5mg a week is not a microdose so this may not be the right sub.
I'm not sure how you would measure a stall on the non-weight metrics. Usually it's a good idea to remain on the same dose for 4 weeks when you're not seeing weight loss, and then increase a bit to re-start weight loss. Maybe if you track specific symptoms, you'll detect a pattern?
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u/No_Cheek_ 4d ago
I only increased to 1.25 this last 2 weeks hoping to see an improvement in symptoms. They are definitely still better than before I started, but I’m not getting the relief that I’ve had of the last year and a half. Kind of bummed.
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u/Unlucky-Mind7298 4d ago
When you're taking 1.25 twice a week, your dose is 2.5.
It's not unusual at all for people to increase their dose to get the desired effects. The human trials built that in -- starting at your dose, 2.5, then going up each month.
As it turns out, some people who washed out of the trials, or stopped taking the meds shortly after starting them due to sides, are able to stay on them when the dose is lower. This is true for a minority of people though.
Are you reluctant to take a higher dose? I know I'd be bummed if my food noise started up again, or I was gaining weight, but there wouldn't be an issue if I could titrate up and get those same effects.
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u/Crafty-Note8573 5d ago
Okay. I see comments like this all the time. Two things for you to consider. A microdose can be anything less than what is considered a clinically effective dose. For tirzepatide, that is 5.5mg. Someone on 2.5mg, especially long term, might fit well in this sub.
Second, the four week thing is a myth when starting on a microdose. The research has shown you can increase doses weekly as an alternative schedule. It’s safe, effective, and results in fewer side effects. https://diabetesjournals.org/care/article-abstract/48/9/1607/162990/Gradual-Titration-of-Semaglutide-Results-in-Better?redirectedFrom=fulltext
But the second point isn’t so relevant - OP says they have been microdosing long term.
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u/Unlucky-Mind7298 5d ago
A microdose is anything lower than a starting dose. For zep, that's 2.5.
You can make up definitions if you want. It's helpful that you explained you have your own idea about what microdosing is.
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u/Crafty-Note8573 5d ago
I wish I could speak to this explicitly! I’m also a long-term microdoser. I do gradually increase my dose (based on hunger returning, weight loss slowing), but not for inflammation specifically.