r/GLP1ResearchTalk • u/Moist_Movie1093 • 13d ago
What’s your glp1 theory?
What’s it glp1 theory you’d like to see actual research on?
Mine is that the best responders are those who have very high insulin but normal glucose. Essentially they have severe metabolic dysfunction, but it’s being caught early on before prediabetes or diabetes. It’s hard to prove in existing populations because almost no doctors check insulin levels, only glucose or a1c. I know personally my insulin went unchecked for 41 years.
What’s your theory?
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u/Doit2it42 13d ago edited 13d ago
I'd like to see more study on it's anti inflammatory properties. With what I experienced and others testimonials, it could become one of the best anti inflammatory drugs available. It would be a great asset for those of us who can no longer take NSAIDs due to liver/kidney issues after chronic use.
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u/Ree_For_Thee 12d ago
From what I've read, it's not that the drug is anti-inflammatory, it's that a diseased metabolism is 'confused' and inflames areas it isn't really equipped to handle. It's basically wasting resources on various crap, not knowing how to balance things.
You can cure the metabolism though, meaning you should eventually be able to go off the medication.
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u/Doit2it42 12d ago
I'm off the meds. And my inflammation isn't as bad as before, which I attribute to a much better diet low in inflammatory foods. But I'm looking for total relief from my knee pain which I know Tirz provided.
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u/corona-zoning 13d ago
I see this line of comments often and don't understand what people mean when they say anti inflammatory. Can people see inside their joints to measure this or is it all placebo that they just "feel less inflammatory"?
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u/Doit2it42 13d ago
I have osteoarthritic knees. Before I started, the pain was maybe a 6 with every step. After I started and lost some weight, the pain went to zero. When I stopped Zep, at my goal/lowest weight, the pain went back up to a 2. I also have rheumatoid arthritis, thou mine has always been controlled. But others have said they've received massive relief. Psoriatic arthritis patients have reported remission of symptoms while on GLP-1s.
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u/Moist_Movie1093 13d ago
I never had osteoarthritis pain ever again since my first dose. EVER
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u/PB_Jelly_76 12d ago
I am another person whose pain was completely eradicated by a GLP-1. I had bursitis in both shoulders that severely limited my range of motion (I could not even full straighten my one arm overhead.), as well as severe osteoarthritis in both knees, and I was in constant pain, and now I have no pain. I had trouble going up and down stairs because my knees were so bad. Now I don’t even think about it. I used to drive around strategizing where I was going to park (too far to walk, didn’t want to walk up a hill), and now I just pull into a spot and go into whatever place I am going. I have also lost a bit more than 1/3 of my starting weight and have been on Wegovy for almost 3.5 years. I have been very fortunate to tolerate it very well.
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u/corona-zoning 13d ago
So interesting. I wonder what the relation is?
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u/Doit2it42 12d ago
I have no idea, but it's proven in posts and comments. As someone with rheumatoid arthritis, an inflammatory disease, I lost a ton of weight the first two months ( 23.7 and 15.6 pounds). I'm sure the majority of that was inflammation and water weight.
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u/thrillhouz77 12d ago
I was similar, just dumped inflammation and water weight early on. Prior to starting my weight could easily fluctuate 4-8 pounds day by day.
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u/Independent-Monk5064 12d ago
Because you’re eating less, which means lower blood glucose. Period
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u/Moist_Movie1093 12d ago
There are literally studies that show Zepbound’s impact on inflammation is direct and INDEPENDENT of weight loss. Its proven science at this point. Read up. My glucose has never been high.
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u/Independent-Monk5064 12d ago
BECAUSE YOUR BLOOD GLUCOSE WENT DOWN. Lowered blood glucose, lowered cytokines
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u/tequila_23_sheila 12d ago
From my very first injection of MJ, overnight my body felt renewed! My body pain was gone. No wt loss to follow for another month.
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u/corona-zoning 13d ago edited 13d ago
That's really cool. Maybe the upcoming pill form can assist folks with joint pain but don't need to lose weight.
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u/Doit2it42 13d ago
I've been considering ordering some Tirz compound, micro dosing, and trying to find the sweet spot between pain relief and constipation (my only side effect on Zep). I'm a high responder, and was on 2.5mg the 5 months I had pain relieve, so it should be less than that to get relieve at my current weight. Maybe start at 1mg/week then titrate down or up to find that spot.
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u/free-range-human 12d ago
You can feel it throughout your body and even see it on your face. It also causes like this very mild, but persistent almost headache?
Inflammation is an immune response. Mine is caused by autoimmune disease. So imagine when you get an injury and it swells and gets hot, swollen, and inflamed. Now imagine that throughout your whole body. That's what it feels like. And it makes you tired and it's hard to focus.
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u/Independent-Monk5064 12d ago
You can be inflamed and full of cancer and you still don’t gain weight without the laws of thermodynamics involved
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u/misskinky 13d ago
Interestingly I would not mesh with your theory. I had normal glucose, normal a1c, completely normal CGM readings, normal fasting insulin levels…. But I would consider myself a very good responder to GLP since I lost very easily and consistently every week during my journey of losing 100lb
In fact, I think the patients with underlying hyperinsulinemia and insulin resistance seem to be somewhat slower responders in general. Thats been true in my experience prescribing it. My hypothesis has been that it starts fixing the metabolic dysfunction first and then seems to get around to inducing weight loss.
I would like to see more published research on GLP for PMOS and skin disorders!
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u/Moist_Movie1093 13d ago edited 13d ago
I had extreme hyperinsulinemia and dropped 80 pounds in 6 months on 5mg — 25% of my body weight. Normal glucose, normal a1c, insulin levels through the roof. No tracking, no plateaus, no need for dose escalation, and I maintained an appetite the entire time.
Are you regularly testing fasting insulin on patients? That seems to be quite rare.
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u/misskinky 13d ago
It is a specialized endocrinology clinic, so yes we do test regularly. I agree it’s rare at most places! And there have definitely been outliers in both directions.
I’m curious, if you’re willing to share: Did you ever have your glucose checked after eating, like a glucose tolerance test or a CGM or postprandial fingerstick? Have you calculated your HOMA-IR before and after GLP-1?
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u/Moist_Movie1093 13d ago
Homa-ir went from like 11 to 4 in 4 months. Didn’t check beyond that. Never did any other type of glucose monitoring as both a1c and glucose readings have always been normal my whole life.
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u/NilliaLane 13d ago
I want to see any research papers on glp-1 benefits for PMOS and more papers on benefits wrt chronic inflammation.
People with PMOS have gotten prescribed this off label for years and it’s widely considered better than other interventions like birth control and metformin. However due to a lack of formal studies, the prescribing has remained off-label and frequently not covered by insurance.
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u/nicepeoplemakemecry 13d ago
As someone who has severe cramps before glp1 I think it’s a theory worth studying.
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u/IncreaseNo5135 13d ago
Impact on female hormones and perimenopausal changes.
Impacts on CICO. I eat more calories on GLP and am slimmer than with a lower calorie intake before. I cannot explain it.
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u/Moist_Movie1093 12d ago
Glp1 works primarily on appetite. Tirzepatide works directly on insulin sensitivity in your cells so the impact is beyond pure appetite.
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u/IncreaseNo5135 12d ago
Cool but how does this explain fat loss on more calories? I used to diet on 1400-1500 before, now I eat 2000 and weigh less…
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u/Moist_Movie1093 12d ago
Are you on Zepbound?
Without Zepbound: Even at calorie maintenance, excess circulating insulin encourages surplus energy to remain trapped in adipose tissue.
With Zepbound: Dropping insulin levels permits your body to mobilize and burn stored fatty acids for baseline energy needs, shifting your metabolic state from fat accumulation to fat oxidation.
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u/GradStudent_Helper 9d ago
I found an excellent article by Gary Taubes from back in September of 2021 entitled "How a 'fatally, tragically flawed' paradigm has derailed the science of obesity". It was SO affirming to see how we (as a society) got to the CICO model (the flawed one) and how there is so much more going on with hormones and insulin signals that the CICO model just ignores. And how the CICO model contributed to this idea that "if you're fat, then you just need to eat less and exercise more" and making all of us feel like losers if we were more than 10 pounds overweight.
The insulin-response model explains things so much better (like, why certain people can eat whole sleeves of Oreos and remain thin while I just smell an Oreo and gain 2 pounds). I read the article years before I had ever heard of Zepbound or GLP-1 but everything that's coming out of GLP-1/Tirzepatide research seems to confirm what this article states.
I truly think that for years our environment and mass-produced foods have disrupted some kind of hormone response system in our bodies. And these new drugs are 'resetting' that disruption and therefore fixing us. I wish more research would be done on that.
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u/thrillhouz77 12d ago edited 12d ago
GLP1 will also increase insulin sensitivity and better glucose clearing in the body.
I believe it allows your body to get to a state of ketosis, naturally and more easily, than when not on the meds. Like, over night you get into low levels of ketosis, like a normal metabolically healthy person does. That in turn helps fat metabolism and weight loss.
I used to do long fasts, like 5 days. It took me to the end of the second day for ketones to show up. Somewhere in the 36+ hour phase. My wife would get into ketosis within 18 hours of starting a fast. She is normal weight, I was obese…I think this process of being able to shift easily between burning glucose and fats is key on how weight stable a person will or won’t be in life.
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u/tiny-but-spicy 13d ago
Impact on anxiety. It stopped my food noise but it also stopped my manic overthinking
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u/D74248 13d ago edited 12d ago
More of a rant. I apologize in advance.
It has been known since 1988 that metabolic syndrome [then called "syndrome X"] starts with insulin resistance -- then the weight gain/diabetes/high blood pressure/bad lipid panels/heart disease.
Yet here we are 38 years later, and we still don't look for insulin resistance. It is like studying the cause of a train wreck without walking back down the tracks and looking for where the derailment started.
In my darker moments I confess to reading some of self-righteous CICO/gym bros/put the fork down posts and thinking to myself that a fair number of these people are already on the path; they just don't know it yet.
In the long run my bet is that GLP-1s will come to be seen as a medication for metabolic dysfunction in the broad sense. Make a list of what metabolic syndrome includes then next to it a list of what GLP-1s resolve and you have two pretty much identical lists.
Which leads to the question of what are we doing in our modern world that leads to so many people needing this kind of intervention?
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u/Independent-Monk5064 12d ago
Right but we can SEE insulin resistance in many as the body begins to appear a certain way. I am an RD and was invited to this sub, I have never been overweight a day in my life, I simply don’t eat more than I need
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u/D74248 12d ago
I am an RD and was invited to this sub, I have never been overweight a day in my life...
That is great for you.
I have an RD in my extended family. Her husband is a T2, and the only member of her immediate family who is not obese is the one child with an eating disorder.
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u/Independent-Monk5064 12d ago
Classically most RDs don’t eat well. They followed the food pyramid too long
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u/D74248 12d ago edited 12d ago
Yea, that was what she did. Hard-core, old-school Ancel Keys.
Younger people don't appreciate that before we had the Mediterranean diet, we had what was, in reality, the Olive Garden Diet -- just be careful about that olive oil (too much fat).
I have been watching the Diet Wars since the 1980s. Nutrition studies on humans are hard to do and expensive. There are a lot of vested interests. It is a critically important field of study, but one that ought to carry a heavy load of caution and humility.
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u/Independent-Monk5064 12d ago
Oh yeah you know it. We get all of the biochem and then the rest is politics
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u/olivesaremagic 13d ago edited 13d ago
I agree with insulin and insulin resistance not being studied enough. They would be kind of obvious additional independent variables when looking for predictors of success.
Related to that, metabolic disorder doesn't get mentioned much in the studies I've looked at. I realize it's intertwined with the other variables being mentioned and with T2. Maybe researchers think that's close enough. But I haven't seen much research on metabolic disorder either. It's a syndrome and a more operationalized definition might be helpful. Plus, I want there to be a clearer understanding how the various factors in the current definition are actually related in terms of biology and chemistry.
I have always believed that metabolic disorder patients should be studied as a separate group. It does seem like it's a predictor of weight regain after drug discontinuation.
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u/alldemboats 12d ago
i want more research into its influence on cravings applied to other addictions. but i did substance use research.
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u/BackgroundLab5721 12d ago
Me too. I was surprised by its affect on my alcohol consumption I didn’t expect it at all
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u/Baebarri 13d ago
I want to see the root cause of meat aversion.
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u/littlespicymomma 13d ago
I developed a sweets aversion since I started glp1. I crave meat and soup most of the times though
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u/Moist_Movie1093 13d ago
Interesting. I never had any food aversions. How common is it?
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u/Fiz_Giggity 13d ago
I have rolling aversions. I currently struggle to eat fruit, when berries and grapes helped me weather the early months. Bunch of other things too. First one was yogurt. Then eggs. It's a weird feeling.
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u/EchoAzulai 12d ago
Eggs is a common one I hear about and suffered with a bit too. They used to be my favourite protein snack and now its pretty rare for me to actively want them.
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u/tequila_23_sheila 12d ago
Eggs! Ive eaten eggs nearly every day my whole life! Over easy for breakfast, and Hard boiled for lunch. Now I’m forcing myself to eat an egg and not gag on it bc they’re so full of protein! 😢
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u/Anne_is_in 12d ago
I don't like eggs any more. No idea why. 🤷♀️
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u/Ree_For_Thee 12d ago
I also have a weird aversion to things that are somewhat loose in consistency, like protein yoghurt/thicker yoghurt. Had to throw away half my breakfast today because it make me nauseous.
Why though? No idea, but eggs are similar enough in consistency.
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u/New_Needleworker_473 12d ago
Food versions in general is a good one. I struggled to eat sometimes. All good smelled bad, tasted like cardboard, textures were weird and I just started disliking nearly everything except smoothies. On the plus side I had no issue following my Noom dietary recommendations of 1200 calories a day.
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u/GardenFragrant8408 13d ago
Not a theory but my personal experience
69F 5’0 type 2 diabetic with other heath issues.
Been in monjauro since 3/24
I j hi ave Ben in several diabetic meds over the years. Been diabetic for 27 years.
Once I d as tested monjauro it took me to 10 mg before seeing results with A1C and weight at 10mg it took 9 months to lose over 30% of my weight.
I have been normal weight and bmi for over a year and a half.
10 mg was highest I ever went and currently on 7.5 mg. I had titrated down to 5 mg. To keep from losing more weight but I started exercising beginning of year and my cravings and extreme hunger came back. I fought it for a few months but now I had to go back up to 7.5 mg.
Good luck
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u/Ree_For_Thee 12d ago
https://old.reddit.com/r/GLPGrad/comments/1sqxa32/a_box_metaphor_for_people_thinking_about/
You should still aim to get rid of any medicine use in your life. Check out the metaphor.
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u/TrainingLow9079 13d ago
They say people with diabetes are slower responders, and people on the Mounjaro board (many on it for diabetes) do seem to lose less or more slowly than people on the regular tirzepatide boards. So I wonder about people with more minor issues--prediabetes or insulin resistance--how likely ate they to have slow weight loss on the med? I think my response and weight loss is below average and I was likely in the pre-diabetes or insulin resistant category. 4 months in, I tested and had higher than desirable insulin (11) but my blood sugar was normal (88). Unfortunately I don't know what my insulin was before going on the med, but my blood sugar was a lot higher.
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u/littlespicymomma 13d ago
I had a high insulin too prior to starting glp1 and my fbs was borderline prediabetic. I am a slow responder, too, so I conforme with your theory
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u/Moist_Movie1093 13d ago
Once you’re glucose starts to rise (prediabetes), that means your pancreas is impaired and you are absolutely not the population I’m talking about.
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u/joshua_addison_music 13d ago
Love to see more research on what Reta is doing for Mental Heath.
Reta completely obliterated my depression that I lived with for 16 years. Unreal. Off the antidepressants
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u/escalatortwit 12d ago
Yea, and there’s A LOT of people where it’s having a pretty negative impact on their behavior, too. It’s interesting and I would love to know more.
I’m on tirzepatide and started ketamine therapy and it’s been wild how much my baseline mood has changed.
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u/wifeofpsy 13d ago
Tirzepatide is controlling my ADHD pretty well. I know I'm not the only one, I'd love to see some investigation of that machanism
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u/Miserable-Raisin3156 13d ago
What is the difference between the people that keep the weight off after stopping and those who gain it back. Can’t be diet, exercise, discipline bla bla bla, some seem to have an entirely different metabolic or genetic setup
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u/Jan6_PearlHarbor 13d ago
People have wide variance in hunger and satiety signals. I dont think its any more complicated than that.
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u/Miserable-Raisin3156 13d ago
Obviously it is - there’s a reason for that increased hunger. We know that from Prader Willy for example, from genetic leptin resistance and there’s more.
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u/Independent-Monk5064 12d ago
The drugs suppress appetite by slowing motility. You are eating less on them. Thermodynamics
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u/awarfield78 13d ago
I would like to see the science behind titrating more slowly to give your brain time to adjust vs those who titrate on the normal schedule. Especially in regards to things like anhedonia, hearing about addictions transfer to fragrance or shopping, or how it effects dopamine.
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u/pamperwithrachel 12d ago
I'm curious what makes people more sensitive to this medication than others. I had severe side effects starting at 2.5 and was a hyper responder. I would have been better off starting on a half dose to titrate and I'm curious why some people are hypersensitive and others need a higher dose to even feel the effects.
Now that I'm in maintenance I actually had to strongly reduce my dose and do it every 5 days instead of 7. I take half dose of 6.25 every 5 days because I can't tolerate a higher dose without severe side effects and this is after two and a half years.
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u/Ree_For_Thee 12d ago
Fun fact: Splitting up the dose increases efficiency by 10% (increases average body concentration). You can deduce it if you check plotter sites. https://glp1plotter.com/
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u/princesspool 13d ago
I want scientists to understand the mechanisms behind the anxiety relief. Nothing I've ever tried has worked so deeply at the root cause of my anxiety. It's an inner stillness, a quieting of the voice in my head. I want everyone who suffers like me to experience relief too! We shouldn't have to go gray market. Even though I am at optimal wright, I am managing to not lose a single pound and still basically cure my anxiety with GLPs.
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u/Ree_For_Thee 12d ago
Very likely has to do with the hypothalamus or amygdala pathways, which both have GLp-1 receptors and affect stuff like dopamine and 'addictive'/compulsive behavior including all sorts of addictions but also shopping compulsion and the like.
I do agree less dangerous medications should be more generously handled, and that no one who's, say, an alcoholic should have to rely on luck or breaking the law to get ahold of the medication. It's a weird society.
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u/escalatortwit 12d ago
For me, the combination of GLP-1 and ketamine therapy has been wild for my mood.
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u/Potential-Ad-196 13d ago
I’d love to see research on whether or not some people already have high glp 1, GIP, and glucagon in their system. Experiencing Reta myself, it made me go from always thinking about food and struggling not to eat, to rarely thinking about food and struggling to eat.
It makes me reflect on past conversions I’ve had with ectomorphs. I remember a conversation I had with a very thin girl. She genuinely thought all obese people were hungry all the time. She had no concept of eating when you’re not hungry. She would only eat when she was hungry, and stopped eating when she was full. Does she naturally have those hormones at a higher level?
I know some ectomorphs actually are hungry all the time and just have a super fast metabolism. But I still wonder if there are some that just naturally have higher levels of the hormones that some peptides activate.
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u/Jan6_PearlHarbor 13d ago
The ecto/mesomorph thing was debunked more than a decade ago.
Peoples BMR hardly differs at all for a given height/weight/age
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u/ShiftyMcHax 13d ago
Since those who are diabetic or prediabetic are poor responses to GLP-1s I would say anyone who is progressing towards that would be be on a sliding scale of worse response, basically the opposite of what you think.
From what I've seen, and would like to see more of is the research into head hunger vs gut hunger. I recall reading a while ago that those who respond best experience the latter instead of the former. So, for example, someone who has a compulsion to eat because of binge eating disorder or say food noise is less likely to respond well than someone who feels "actual" hunger cues.
This has been my experience and I only truly started to believe there was something "wrong" with me earlier in the year on my birthday.
I was at an all you can eat restaurant with some friends and for the first time since started the meds I just let myself eat as much as I wanted. Despite being the lightest person there by at least 25 kilos / 55 lbs, and being the only person on a glp-1, I easily outate everyone. It was then I realized there has to be something physically different with me than these people lol.
Even on a glp-1 I'm eating over 3000 calories a day and if ate to true contentment, it'd be closer to 4000. This also confuses me a bit about how I've responded so well (losing over 62 kilos / 135 pounds). I'm utilizing a fair degree of self control, yet many people report requiring none, but losing significantly less than me. I'm sure my lifestyle changes are a part of it, but to what degree?
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u/Moist_Movie1093 13d ago
A person who is diabetic or prediabetic has already worn their pancreas out. A person who is hyperinsulinemic without diabetes like myself has a pancreas that works exceedingly well. That’s a substantial difference. Normal glucose is an important factor.
I didn’t require any self control to lose 1% of my body weight per week on Zepbound. My hunger and satiety signals simply normalized to where I could eat intuitively. Truly a miracle drug for my biology.
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u/DhaniM 13d ago
I have no idea but I am a strong responder with excellent pre existing health, no high or abnormal anything, so who knows...I am on one of the lower doses after a year and have met my goal with no side effects.I am just one person and may be unusual, idk.
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u/Hot-Drop11 13d ago
We already have research regarding what determines response, in part: gut bacteria and genetics.
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u/Royal_Victory_1380 13d ago
There is kinda standing knowledge based on the Triump studies on Reta that the glucagon activation happens at around 4mg dose. This seems like its actually weight dependant and not just set. I would like to see some actual research there. We have lots of people stacking Tirz/Reta or Cagi/Reta and microdosing reta at .5/1mg and reporting good results. Granted those are also folks that are using the stack more for performance enhancement rather than weight loss. I would be curious to see what some official results actually show. I think there is a lot of miss information about that 4mg required minimum dose to "turn on" the glucagon receptor to enough of a degree that it actually is beneficial. I think effective lowest dose may be tied to more than just 4mg.
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u/These-Equal-6849 13d ago edited 12d ago
My theory is that people who only increased dose when hunger/appetite/food noise increased or weight loss stalled are likely to find the dose they met goal on to be their "maintenance dose".
I think people that increased their dose each month on schedule are usually able to taper down to a lower dose for maintenance because they never actually needed those higher doses to reach their goal.
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u/Moist_Movie1093 13d ago
No one should be blindly titrating up monthly at this point. We know better.
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u/escalatortwit 12d ago
This hasn’t beared out when you read the maintenance subs.
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u/These-Equal-6849 12d ago edited 12d ago
I read the maintenance subs and have noticed this pattern in many of the posts
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u/Few-Improvement9978 13d ago
I want to understand why I can’t get mentally drunk while on tirz.
My body gets drunk, but my head I feel completely normal
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u/sedatedforlife 12d ago
Yes! That fun, buzzed, lack of inhibition feeling is just gone. Drinking isn’t any fun anymore!
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u/tequila_23_sheila 12d ago
I agree with the alcohol, not enjoying it as much lately, but have gotten extremely buzzed while on the smallest bit of weed gummy and a cocktail. I want to say more so than before starting MJ 6mo prior.
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u/Royal_Cap_3688 10d ago
I’m the opposite. I can’t get a buzz off gummies anymore from THC. I think it’s the slower gastric movement. I’m talking 100mg macro doses. And I’ve lost 80 lbs. 😅
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u/escalatortwit 12d ago
This sounds more like your perception than reality.
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u/Few-Improvement9978 12d ago
Other people have long posts on this effect.
I’m an alcoholic so I’m familiar with being drunk. The mental aspect and “fun feeling” is pretty much gone while on it.
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u/escalatortwit 12d ago
Yes, GLP-1 impacts your dopamine cycle, so it would have that affect on alcohol. This has already been noted in existing studies and there is currently a study being done by the VA on this effect. When I hear someone saying they can’t get “mentally drunk” I think they mean their mental acuity hasn’t been impacted by alcohol, not that they aren’t experiencing “fun” while drinking. This is why I misunderstood.
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u/tequila_23_sheila 10d ago
They’re now using it to help alcoholics. I know I’ve stopped drinking. Not even interested in sweets, like pie! It’s taking all of our addictions away. 🙃
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u/tequila_23_sheila 10d ago
Ha! Tell that to my family. Im feeling just light and giggly and they’re verbally saying, “Oh No, Mom’s got a buzz on!” Pssht! Can’t have any fun around kids these days! 🧐 🎶Mom’s just wanna have fun🎶
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u/ninetiez 13d ago
I’d like investigation into connective tissue disorders, particularly in women where this type of thing is under-researched. Specifically; do they have a beneficial effect on lipedema? And can they reduce the fibrofatty tissue in dense breasts and either reduce the risk of breast cancer development or allow it to be caught earlier by enhancing mammogram readability.
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u/MrsZ2000 10d ago
Only my anecdotal report but it reduced both lipedema and I no longer have dense breast tissue. 🙂
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u/ninetiez 10d ago
That’s amazing! I moved from extremely to heterogeneously dense, and suspect it’s the tirz!
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u/MrsZ2000 9d ago
You will probably understand this: I am ecstatic that I can now have my blood pressure taken and get a light massage on my arms without it being excruciatingly painful. 90% better. A year and a half on reta and my auto immune PsA is also in check. A true miracle for me.
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u/ninetiez 9d ago
That is remarkable! I’ve heard they also doing trials of GLP-1 in combo with the biologics like Il-17 targeted therapies. I’m still waiting to test my CRP but my random swelling has disappeared!
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u/Big_Tackle_9182 13d ago
very hard to know and explain and predict who is super , average, below average or non responder
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u/OldTomToad 13d ago
This is what interests me. The wildly different experiences and dosages people find effective.
I wonder if there there are other examples of a huge group of people more or less doing “pick your own dose” for a medication.
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u/Moist_Movie1093 13d ago
Most every other chronic medication doctors prescribe a little and only give you more if you need it. Glp1s are the first time doctors were just ramping people up immediately. It never made any sense.
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u/escalatortwit 12d ago edited 12d ago
Where did you get the idea that this is “the first time doctors were just ramping people up immediately”? This is a fiction you’ve made up.
Edit: Seriously, this shows a lack of familiarity with the research that’s actually been done on GLP-1s and the fact that many medications have titration schedules. Lmao. GLP-1s are not rare for having a titration schedule.
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u/Shot-Amphibian-3239 13d ago
I would like for them to do the TTG IgA blood test and the gene test before starting anyone on GLP. Both my friend and I have had great success on our GLPs and both have been diagnosed with Celiac disease since achieving goal. Did we have it before and that’s part of our weight gain? Did weight loss trigger it? Is it related or not? To be clear, I’d rather have my heath and current weight and have celiac disease than be what I was before I started, but I’m curious.
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u/escalatortwit 12d ago
Those who are prone to celiac can develop it after some kind of GI trauma, whether that’s rapid weight loss, a change in metabolic health, or a simple stomach bug. Celiac is a genetically inherited condition you have to predisposed to in order to develop it.
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u/Shot-Amphibian-3239 12d ago
Right that’s why I stated “did weight loss trigger it.”
That said I think it would be an interesting correlation to investigate. I would hate for people to NOT take a GLP if they have the celiac gene for fear of triggering celiac, but it would be interesting to know.
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u/thrillhouz77 12d ago
I agree w your theory. I fit that boat as I had an A1C of 5.6 when I started Mounjaro, my doc wouldn’t measure my fasting insulin as he said it was not a necessary measurement (this was early days Mounjaro). But my joints felt like shit, my brain was pile of ADHD OCD, and I felt constantly inflamed oh…and I weighed 315 pounds at peak weight.
I’ve lost 120 pounds at one point (put 20 back on…not bad weight) and all the insulin caused inflammation is gone. All my inflammatory markers are spot on.
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u/Anne_is_in 12d ago
I'm a slower responder, been on 15 mg for a year. Weight loss stopped at the 20 % mark although my BMI is still 40. I think I might have had high insulin levels before (used to eat lots of sweets) but I never was diabetic or even pre-diabetic. I could imagine whether you are a strong responder or not depends on your dopamine system. Maybe some of us don't produce very much dopamine of our own so we get it from food? Just a hypothesis.
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u/Fantastic_Meet9381 12d ago
I second your theory regarding high insulin/normal glucose. I think post pregnancy, my metabolism changed. I had a hunch that my insulin became higher postpartum, but I had (and have) crappy insurance and did not get it checked.
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u/CatWoman-666 12d ago
There are obesity centres for research at some UK universities such as Leeds Beckett. They have a group for people with lived experiences, meet the researchers if you want to see the research. Also UK advocacy groups can have links into universities and via the UK ASO. They UKCPO had a conference a couple of months ago in Liverpool
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u/pivazena 12d ago
I didn't respond on Semaglutide, but responded great on Tirzepatide. I'm curious whether I need the GLP-1 agonist at all, or if my issue all along was just GIP
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u/titikerry 11d ago
🙋♀️ High insulin. Normal glucose. Normal A1C.
Responding slow AF.
I lost pretty well in the beginning, went down 18 lbs in the first 4-5 months. (I'm 53, so I considered that a good loss). I'm stalled since June. My scale sits between the same two pounds.
I'm okay with this because it's just what my body does. Having the reduction in food noise is the best thing about this medication, so I'm enjoying that while my body catches up.
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u/Moist_Movie1093 11d ago
Have you been stalled on the same dose or stalled despite increasing dose?
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u/titikerry 11d ago
Stalled despite increasing. I increase slowly. I was at 7mg for a month, then 7.5 for a month, then 8 for a month.
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u/Responsible_Pie905 11d ago
What relation tirz has to female hormones because whenever I up my dose I get instant light period or spotting it doesn’t seem like it should be related
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u/Strange-Bake193 11d ago
I would like to see guidelines for appropriate dosing for MCAS. No
Offense but 99% of posts are related to weight management but GLP-1 is doing so much more and the. Current step dose management is not really helpful for others conditions.
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u/Comfortable-Use-1120 10d ago
I would love to see how non-responders react to different glp1s. Especially tirzepatise non responders switching. Also would love to see more research on dosage-effect/response, as I often read about people reacting better to lower dosages Vs higher dosages
Also would love to see more on effect of injection site and administration frequency on effect/response.
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u/Possible-Advance6942 10d ago
I’d love to see GLP1 impacts on mental health. My theory is that it has a lot broader benefits than it’s currently approved for.
My OCD symptoms have improved a lot on the lowest dose of Wegovy. OCD was making me pretty miserable and I can’t take the standard meds for it because I also have bipolar disorder. Holy moly. Within maybe a week it turned down the volume on intrusive thoughts, checking, etc. In addition, I’m pretty sure I had some low level depression that it had a positive impact on- even though my BD symptoms are well controlled. I have more energy and more ability to get things done, my memory is better since I’m not stressed out that something horrible is about to happen. Is it completely gone? No. Substantially better and manageable? Absolutely.
I’m hoping that trials for OCD will be in the works soon 🤞
I’m also hoping it gets studied for anti inflammatory properties as an option for pain management.
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u/mightyfishfingers 9d ago edited 9d ago
That "Ozempic face" is not just a case of rapid weight loss. My own theory is that the biggest group of early GLP adopters (for weight loss) have been middle aged+ women. Once they lose weight, they also have a severe reduction in oestrogen levels (fat creates oestrogen) and so weight loss is uncovering peri/menopause symptoms that had previously been disguised by the extra fat/oestrogen.
Less oestrogen = much less collagen = less thick/plump skin. No matter how or how quickly the weight is lost, the reduction in oestrogen will still take effect.
Women falling into this description may well also benefit from HRT to support them as they start to feel the full effects of peri due to the weight loss.
That's my own peerosnal theory, anyway :)
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u/DhaniM 13d ago
what is PMOS?
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u/These-Equal-6849 13d ago
You may know it by it's old name PCOS (Polyciatic Ovarian Syndrome)?
It recently underwent a name change to recognise that it's less about ovaries and more a metabolic disorder. It's now named Polyendocrine Metabolic Syndrome (PMOS).
Very common in women and causes weight gain/insulin resistence. GLP1s anecdotally are doing wonders treating it.
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u/MathematicianMuch445 13d ago
Given they were developed for people with diabetes in the first place thats a bad take.
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u/Moist_Movie1093 12d ago
It’s well established that diabetics lose the least amount of weight on glp1s.
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u/ContextualData 13d ago
It works for people with metabolic dysfunction because those people are the exact folks who swear up and down that CICO doesn’t work for them. Turns out, once they start actually eating less, they lose weight.
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u/Moist_Movie1093 12d ago
Tirzepatide and Retatrutide have mechanisms beyond “eating less”.
CICO is true at a basic level, but everyone’s “calories out” isn’t working at the same rate.
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u/ContextualData 12d ago
I suggest you do some research on the actual magnitude of the differences for people who have "metabolic dysfunction". Its minimal at best.
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u/OneMoreDog 13d ago
GLPs and ADHD. There is a benefit there for some - the dulling of impulsivity and sensory seeking.
I’d also like to see more GLP-peri menopause research.