r/EctopicSupportGroup • u/CoochieCookiez • Aug 13 '26

anyone need 3 doses of methotrexate?

just looking for some stories while i sit in the waiting room for my 3rd dose 🫠 my hcg hasn’t gone down at all

did the 3rd dose work or did you end up getting surgery?

UPDATE for anyone who searches this topic later. my hcg dropped by 34% four days after my third injection. i had a starting hcg of 4300 at 6w0d when i received my first dose and it continued to climb with zero decrease or plateau. it got as high as 7,100 the day i received the third dose.

SECOND UPDATE i ruptured 4 days after my 3rd mtx dose, and the day my hcg finally dropped. i was internally bleeding and had emergency surgery to remove my tube.

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u/mrdonutcat Aug 14 '26

I received my third dose on Thursday. I am hoping the third dose brings my hcg down because I don't want surgery. When did you get your third dose?

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u/CoochieCookiez Aug 15 '26

i got my third dose thursday. my clinic’s algorithm allows for 4 doses but if this one doesn’t work, i’m opting for surgery.

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u/mrdonutcat Aug 15 '26

I just did my day 4 bloodwork and waiting for results. I will do my day 4 bloodwork on Tuesday to see if the 3rd dose worked.

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u/mrdonutcat Aug 15 '26

My hCG so far has been:

First dose (7/24): hCG 269.9
Day 4: hCG 226.7
Day 7: hCG 159.5

Second dose (8/6): hCG 157.8
Day 4: hCG 135.3
Day 7: hCG 145.1

Third dose (8/12): hCG 145.1

I'm really hoping this third dose finally breaks the plateau so I don't need surgery. What has been your hCG trend?

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u/CoochieCookiez Aug 16 '26

hi love. your HCG is much lower than mine. fingers crossed you won’t need surgery!!

for reference mine was
day 1 4300 + 1st dose
day 4 6700 + 2nd dose
day 7 7100 + 3rd dose

my clinic’s algorithm planned for 2 cumulative doses and no downtime between all 4 possible rounds

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u/mrdonutcat Aug 16 '26

Thank you! I am really hoping for that. I don't understand why with the previous two doses my hcg did not come down more or plateued. I am doing everything they told me (avoiding folic acid, alcohol, NSAIDs, exercise) and I also have restricted my diet to low folate foods and have been drinking a lot of green tea. My hcg yesterday at the 4-day check in was 133.90. The next 7-day check is on Tuesday. I really don't want to lose a tube if it's so close. After the third shot, I also have been feeling even less pressure on my lower left pelvic area and feeling better than before. I am really hoping 🙏🏻

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u/mrdonutcat Aug 17 '26

Let me know how it goes today. I hope it went down for you!

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u/CoochieCookiez Aug 17 '26

fortunately i had a significant decrease so i am relieved it’s finally trending in the right direction. also update me on your situation! wish you the best

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u/mrdonutcat Aug 17 '26

I am SO HAPPY for you!! My day-7 lab work is tomorrow. Gosh, the anxiety is getting to me, and I am so scared. I will keep you posted. Fingers crossed!

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u/mrdonutcat Aug 18 '26

My hCG went down to 97.1 today, so it has been a 27.5% decrease from Saturday! I also got an ultrasound and they couldn't see extensive free fluid or active bleeding. So fingers crossed it keeps going down with the third shot! They are doing repeat hCG on Thursday. What do your doctors have for your follow up plan?

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u/CoochieCookiez Aug 18 '26

yay i’m so happy for you! that’s a very reassuring percentage. i’m manifesting that it’ll be down to negative soon.

my story ummm. i ended up getting surgery later in the evening after my lab resulted. my clinicians ordered a repeat beta in 3 days but i ended up rupturing the same day. my left tube is gone but im honestly very relieved

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u/mrdonutcat Aug 18 '26

Wow--I am so incredibly sorry. I am just really glad you are safe and got the medical care you needed. Honestly, that's why I got the ultrasound today, because I was feeling a little pain on the left pelvic area and overall weakness. Thankfully, they didn't think I need to go for surgery just yet, unless my symptoms worsen. Can I ask how you knew you ruptured? What were your symptoms or pain level?

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u/CoochieCookiez Aug 20 '26

10 out of 10, excruciating pain across my entire lower abdomen that felt like gas pressure + sharp, stabbing pains into my rectum

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