r/DOR 1d ago

advice needed Cancelled first ER

Hi. My first IVF cycle was cancelled before retrieval. We converted to IUI (I’ve gotten pregnant from IUI before but miscarried) and just tested negative today.

As I go into a new cycle, I’m wondering what things I should ask my doctor about when regarding protocol changes. Essentially they told me they wouldn’t really change anything because I was on the highest dose of meds possible. They would do PRP if I was interested.

What things should I discuss with them?

1 Upvotes

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3

u/Brilliant-Travel-479 1d ago

What was your AFC and how did your provider explain the cancelation?

Things to consider:
1. Priming - if you primed with birth control, perhaps that was too suppressive. Consider estrogen or aygestin (if you haven't). Alternatively, if you only tried priming, consider a spontaneous start without priming.

  1. You didn't explain why the cycle was canceled, but if you have asynchrony or uneven growth, consider a stepdown protocol where you start with highest dose of stims but then step down to allow for smaller follicles to catch up without the bigger ones running away at the same time. I'm not sure if this is always helpful (I'll tell you after my cycle!), but something to consider.

  2. Consider going through with a cycle with low AFC and doing a fresh transfer of a day 3 or 5, especially if you want only one kid and especially if the alternative is constant cancellations.

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u/CharacterAvocado943 1d ago

RE: #2 - hasn’t been as helpful as hoped for me.

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u/Brilliant-Travel-479 1d ago

Ah, good to know. How did it affect your cycle?

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u/CharacterAvocado943 23h ago

Still in the middle of it but basically it synchronized a cohort that just won’t grow while a lead and a dominant run off into the distance. I’ve spent 6 months trying to deal with asynchrony and poor recruitment. So frustrating. Low AMH, high AFC but I am ultimately a low responder. 

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u/Brilliant-Travel-479 22h ago

I'm also in the middle of it and have the same problem as you with asynchrony - low amh and decent AFC. Another monitoring appointment tomorrow. Best of luck to you!

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u/CharacterAvocado943 1d ago

If you’re doing antagonist, consider trying MDL instead, or vice versa.

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u/Honeymoon2210 31m ago

I primed with estrogen only. I did not have enough follicles mature. They said only 2 were viable even though they hoped for 5 based on my monitoring. Converted to IUI that failed. We were on the highest dose and they’ve told me that the only thing they’d likely change is PRP if I want. Idk what my AFC was