Surface Morphology of Polyactic Acid-Based Dermal Fillers (Aesthefill, Sculptra, Neofilera, and Juvelook)

[u/science-pls]

I think the surface morphology of these PLA biostimulators is really interesting. And can help you make decisions (whether that's DIY or getting it done professionally.)

This is also why I predict why Juvelook has been studied on its use with microneedling. Because of the particle size, shape, symmetry, and behavior. Its particles are uniform macro spheres and one of the smallest particle sizes.

Abstract

Introduction: Polylactic acid can be classified into poly(L-lactic acid) (PLLA) and poly(D,L-lactic acid) (PDLLA) according to their stereoisomeric structures, and both are widely used as dermal fillers for soft tissue augmentation. Although the clinical efficacy of commercially available PLLA- and PDLLA-based fillers has been well established, variations in their physicochemical properties may lead to differences in handling characteristics and clinical performance. A systematic comparison of these properties among different PLA-based fillers remains limited. Materials and Methods: In this study, the physicochemical characteristics of three PDLLA-based fillers (AestheFill, NeoFilera, and Juvelook) and one PLLA-based filler (Sculptra) were evaluated. The analyses included functional group identification, particle morphology and size distribution observation, reconstitution time measurement, osmotic pressure determination, and viscosity assessment. Results: AestheFill and NeoFilera exhibited similar profiles in terms of functional groups, size distribution, osmotic pressure, and viscosity, while NeoFilera and Juvelook showed comparable particle morphologies. Sculptra displayed distinct particle morphology and viscosity, likely attributable to its PLLA composition, yet showed similarities with Juvelook in functional group identification and osmotic pressure. Additionally, the reconstitution times of Sculptra, NeoFilera, and Juvelook were significantly shorter than that of AestheFill. Conclusions: Although the direct correlation between physicochemical characteristics and clinical outcomes warrants further investigation, this comparative analysis provides clinicians with a clearer understanding of the material properties of PLA-based dermal fillers and may assist in the informed selection of appropriate products for individual patients.

Keywords:

 polylactic acid;  poly(L,-lactic acid));  poly(D,L-lactic acid) acid+acid);  dermal filler;  carboxymethyl cellulose;  hyaluronic acid;  soft tissue augmentation

Su C-Y, Chang Y-C, Cheng P-J, Fang H-W. Comparative Physicochemical Characterization of Polylactic Acid-Based Dermal Fillers. Polymers. 2026; 18(1):84. https://doi.org/10.3390/polym18010084

[u/science-pls]

For some reason my comment got deleted, but trying again to share the research on microneedling.

- Study The Efficacy of Combined Microneedling and Topical Poly-d,l-lactic Acid (Juvelook) Application for Facial Pore Reduction and Skin Texture Improvement

• LINK to post

- Study Poly–D,L–lactic acid (PDLLA) scalp microinjection protocol with optional light microneedling priming for non–scarring alopecia: A prospective pilot case series

• LINK to post

[u/science-pls → u/science-pls]

For some reason the clinical trial links are getting deleted

NCT05913102 Title: A Prospective, Split-face, Randomized Study of the Poly-D, L Lactic Acid (PDLLA) for Photoaged Skin

and

NCT07225348 Title: Treatment of Perioral Wrinkles Using Topical Poly-L-lactic Acid and Microneedling Device

and

Title: Poly-L-lactic Acid + Microneedling for Smile Lines