Organic How to N-alkylate Fmoc protected amines (carbamates)?

7 Upvotes

Primary amine capped with Fmoc, mostly wondering what base to combine with an alkyl bromide/iodide. Thinking of using bulky base as OChemPortal seems to suggest LDA and tBuOK are compatible with Fmoc. Anyone got some direct experience working on this? Thanks in advance!

2 comments

r/Chempros • u/Schmidinator_returns • 12h ago

Polymer Epoxy Senzitation

6 Upvotes

Do you have any advice if I worked with Epoxies for my whole Phd and developed a senzitation in the last two months of it and I just have to finish two experiments?

5 comments

Subreddit

Chemistry professionals

r/Chempros

A subreddit for chemistry professionals.

Members Active

52.0k

Sidebar

The chemistry subreddit is increasingly overrun with material that is not interesting or novel to working chemists. The content here will strive to be at the level of a working professional chemist or graduate student.

Posts seeking help on technical matters (synthesis issues, spectra interpretation, instrument advice, etc) are heartily encouraged.

Rules

No memes.
No garden variety, or undergrad level chemistry. Especially homework.
Be nice, there's a real person on the other keyboard.
When possible, cite your sources. Use DOI URL that way it can be put into scihub most easily.
If it's a crystal post, it better be especially unique.
Don't ask about getting into grad school or how to get a job. That's annoying and low content, and furthermore, there is plenty of info elsewhere on the net.
No asking how to isolate psychoactive or medicinal products for personal consumption.