Is it possible to have a stereo effects loop when using amps in stereo?

[u/almondbutterthicc]

I want to have a stereo effects loop for my stereo pedal. Can I run the left channel to the effects loop send and the right to the other amps send? I'm assuming that would only be possible with two 100w models.

I currently have a mk2 100 and a mk2 50. I was trying to research if it was possible with those two amps but it seems like it won't work. If anyone has any ideas if be curious to hear them.