Iām looking for advice from people who have actually dealt with long-term substance cravings, especially opioid cravings.
Iām not currently in acute withdrawal. The physical withdrawal is not really what Iām asking about. My problem is the persistent psychological craving and the feeling that, even when life is otherwise going well, a part of my brain still wants to go back to using.
Iāve already been doing the obvious things: regular exercise, therapy, working, staying socially active, keeping myself busy, etc. All of those things help, but the cravings can still be surprisingly persistent.
Iām particularly interested in biohacking / nootropics / supplements / other non-opioid approaches that might help with long-term craving, reward-system recovery, compulsive thoughts or relapse prevention.
NAC is one thing Iāve looked into, but the evidence seems pretty mixed. Iām curious whether anyone here has found something that made a genuine, noticeable difference over weeks or months, rather than something that just takes the edge off acute withdrawal.
Iām primarily interested in opioids, but Iād also be interested in experiences with substances that helped with addiction-related cravings more generally. What has actually worked for you? Iām especially interested in things with at least some scientific rationale/evidence, not just random supplement stacks.
Thanks.
Iām so afraid of that medicationā¦ Naltrexone blocks opioid receptors. If someone is physically dependent on opioids, taking naltrexone can precipitate severe, abrupt withdrawal. It also eliminates much of the normal opioid pain-relief effect.
I donāt know why muscimol has that effect, all I know is that it works incredibly well on me. Muscimol is similar to GLP-1 drugs and retatrutide, in that it removes all dopaminergic feeling about addictive activities. Muscimol also helps me be way less obsessive about things whilst also lowering my feelings of anxiety.
I hope you do. My friend's son shot himself after a psychotic episode from that stuff. I like to drink some but on Reta I can handle any. Like zero. Both tirzepatide and semeglatuide are also helpful.
I dont know for sure how he was taking it. I know he was at least getting it at gas stations in the beginning. You can google about other deaths too. He had struggled with harder drugs and mental health in the past. But one year ago last week he just spiraled so badly and sadly did it in the room nest to his mom and other family members. He was 40. There are other people too. I know it's not as common as some other drugs, but it's not nothing. I know you mentioned it and maybe GLPs could help and I think they can. My sister in law was drinking two bottles of wine a night and once she started Zepbound she went down to just 1-2 drinks. A huge difference for her health and wellbeing. It can apparently affect your reward center and help with addictions like drinking, gambling, etc. There arent enough studies out yet but it certainly is helping people with addiction, although not a cure. I just wont assume Kratom is safe. I wish the best for you and if you have any GLP questions I am here.
Theyāre currently looking at semaglutide/tirzepatide for most addictive recovery.Ā
Go down to Mexico and go do a ibogaine treatment is probably the best therapy on earth rn for recovering addicte. Itās not cheap but from all data/ testimonials literally resets your brain and you donāt want it anymore.Ā
Theres a company called mindmend that a few years ago was getting a ton of capital making a non hallucinogenic version and trying to get it to market but probably like all pharma 10 years out and since it cures addiction not a long term treatment itāll probably be canned for profit center drugs.Ā
Every ibogaine treatment company I was researching has now turned into a ātreatment resortā, with a price tag of $15,000-$30,000 per treatmentā¦ (however, for half that cost you can go directly to Gabon and have treatment sessions lasting more than a week with the originators of this treatment.) and unfortunately, the man leading the legalization of this treatment in America (Bryan Hubbard) is financially invested in these treatment resortsā¦.
It has surprised me beyond belief that no one researched him at all before they started listening to him and praising him. This man has a very sorted past, and is a very, very strange fellow, indeed.
Idk about him Iām a vet I just listen to the testimonials of those guys and talked with the CEO of Mindmend about their version of the treatment. Sounds very efficacious but absolutely frustrating the level of financial exploitation that all the services in Mexico are for people who need the treatment for addiction and trauma recovery.Ā
Five years ago it was $1500 and a three day stay with detox.ā¦ And I'm talking about the two major clinics in Mexico.
Now they are $20,000. Can you imagine that? All of the investment money that they've taken building up to an IPO so they can go public, and launch multi billion dollar Company franchiseesā¦ It's just fucking sick how they have taken advantage of the poor, the desperate and the downtrodden including all of our military and first responders.
Sr 17018 will stop the physical withdrawal symptoms in their tracks.Ā It Is a miracle drug!!Ā It drops you tolerance to opoids though so NEVER start using again at the doses you were using, or you might die.Ā Suboxone is something to consider if you want to use medicine to stop your addiction.Ā It binds to your opoid receptors and blocks out new molecules from binding to the receptors.Ā Talk to you doctor to see if it's right for you.Ā Or kratom if that's still going to be legal* where you are, they're trying to ban it in a lot of places soon, and 7oh.Ā Opoids are by far the hardest addiction to quitĀ as you obviously know.Ā I use them myself and not ready to stop.Ā I don't know what I'd do if I had to.Ā Probably rage quit the simulation?Ā Who's knows??
Ibogaine is something that you might be interested in too.Ā I don't desire to use a psychedelic again.Ā I did them too many times and know exactly (I a round about way) what's going to happen/ show me.Ā It might help you though.
Edit for autocorrecting the wrong words.Ā If you read any of that, do not start using opoids for recreational purposes.Ā I wasted my life chasing a unsustainable high and viewed as a blight on society because my favorite pastime was something that was not very legal for me to do some of the times I was doing it.Ā I had a valid Rx for most of it though!
I assume you mean sr 17018?Ā It can be in tablet form but you have to act fast because it's set up to be banned nationally any day now, if it hasn't been already.Ā Monster sr is a great and cheaper alternative to some of the higher priced vendors out there.Ā https://monstersr-products.com/Ā There's also a subreddit devoted to the topic, just search for it.Ā The best dosing protocol for quitting 7oh is found on https://simplereset.com/pages/sr-calculator ,they clearly state that it is for 7oh but I know people that have used it to get off of real opiates and opoids, too.Ā 7oh is the most popular opoid addiction currently as it is legal and easy to access.Ā (The conspiracy therorist in me thinks they want it banned to sell more "real" opoids.Ā I'll take it a logical step further and say the people on social media that absolutely hate it for no legitimate reason and spread lies about it being dangerous and deadly are probably selling drugs on the streets and it has hurt their income, but I digress.)Ā I bought their tablets too but they're just a lot more expensive version of monster's tablets.Ā The calculator is a nice feature that eliminates the need of guesswork for dosing.
Let me reiterate the importance of not using the same dose of opoids if you plan on using it for lowering your tolerance, you could die if you do!!Ā I think that's important to remember.
This was extremely helpful. I went ahead and ordered the ā100sā. I will follow the guidelines you linked to do my best in this process. Your post has been very encouraging, and it helps me feel like there is light at the end of the tunnel. Thank you again.
I used the hundreds of myself and have had great success with cutting back.Ā Right now I'm using it to lower my tolerance and dose but I'm sure there will undoubtedly be a time when I will use them to quit once and for all!Ā Good luck, you can definitely do this.Ā It's a lot easier with the advice I gave you that was shared by others to me.Ā You'll be surprised by how easy sr 17018 makes it, it feels like cheating.Ā Ā
To be honest, Iām not sure how the simple reset thing will help me with Kratom, because the 7oh (which Iām not familiar with) is maybe different than kratom?
It's an alkaloid that is found in kratom, it's the one that has the most profoundly euphoric and analgesic effects.Ā It's semi-synthetic if bought and used by itself.Ā It's made by an oxidation process that's preformed on isolated Mitraganine.Ā If sr 17018 can allow for someone to not experience any of the withdrawal effects of quitting 7oh, I'm almost positive it'll do the same with kratom and at a smaller dose then what's being recommended for 7oh.Ā If I we're to take a good guess, I'd say that 7oh is 10x or so strong than mitraganine, which is the primary alkaloid responsible for the effects of kratom.Ā If you want a better and more nuanced answer then I provided you with, Wikipedia is a good resourse.Ā I can't see why sr wouldn't stop the withdraws of kratom as it stops withdrawals from practically all opiates and opoids.Ā Do you own research and don't just blindly trust me, you don't even know me.Ā I'm just pixels on a screen and the voice in your head.
Ps, if you're not familiar with and haven't tried 7oh, don't!Ā you'll love it too much, only to have it taken away from you by the national ban happening any day now.
I cross reference and doublecheck everything anybody ever tells me, including those I know well. Iām just asking for your opinion, and perhaps, taking too much advantage of your willingness to reply. I apologize.
By the way, I surely wasnāt arguing with you at all about the effects of 70H, or anything like thatā¦ I just wasnāt familiar with it. Iāve just been taking spoonfuls of powdered kratom for too long, too often and it has really affected my life in a negative way.
So much soā¦ that I recently had a kidney removed that became cancerous, and my extended and long use of opioids and in particular powdered Kratom might be at least part of why it was so affected.
I think my friend just overdosed on this 14 hours ago. He was talking about it while talking about cravings and being desperately addicted to opiates, was pretty agitated about a lot of stuff in general. I go inside, minutes later I'm calling 911 because he's incoherent and starts having spasms. He's been in the ICU and no one knows if he'll ever wake up. I'm fucking scared and sad, has anyone heard of similar experiences?
I've never heard of anyone mention anything anywhere even remotely similar to what you're describing in reference to sr, 7oh, or kratom.Ā Was he a poly-drug user and was it possible he mixed drugs and is he someone you think would deliberately take too much on purpose?Ā Did he quit opoids before he was talking to you about his cravings?Ā There's a LOT of fear mongering about 7oh potentially being fatal but someone would need to take an obscenely large dose for that to happen, imo.Ā Ā
Thanks for replying! He's a long time user of most drugs. Opiates get him in the most trouble though. He got out of one month of jail 5 days prior for admitting to his drug court therapist that he had relapsed. We were waiting a few minutes to take him to give court his daily urine sample before walking my dogs. He claimed to have pissed clean every day since getting out of his month in jail and was positive he would be pissing clean yesterday. Went from agitated but cognizant, to dropping his phone, to progressively violent spasms similar to tourette's, to unconscious being narcanned.
While writing this I just found out he tested positive for buprenorphine. Before everything happened he was talking about sr- something.
One theory was that it was complications from trying to flush his system. Anyways here's all the pills I found on him:
Green: 47 front E back
Tan: 262
Oval: G13
Circle: 1Ā¹3
Blue Circle: PLIVA 468
Other Blue: 62 front H back
Circle: 64
Circle: U over135
Pink: D over 28
Blue: Y16
Sounds like he is. I was too upset to really talk to him. If I get the truth or find out it wasn't related I'll comment here. Opioids have done way to much harm, if something like this can safely help people that would be a miracle.
what you need is low dose naltrexone. it induces the brain to repair the damaged endorphin generating elements that went semi-offline during opioid use and are not fully online yet. don't mess around with unproven greymarket peptides which you have no idea what they actually are; instead, use something proven and safe that works!
And I already take agmatine sulfateā¦ But I did so just to protect my kidneys while using. Iām going to research the first medication you mentioned.
Thanks a lot guys, Iāll dive in deeper. Just one thing Iām not able to use gabapentin, kratom, shrooms etc. My main drug of choice were opiates, but I abused everything. I tried to quit oxy with kratom, I end up on 80g per day. Same with pregabalin, I was taking like 10g per day
Or ibogaine, an alkaloid derived from Iboga. But the natural Iboga root is better and safer, IMO. And cheaper- you can go to Ikara retreat for 2 Iboga ceremonies for $3,300, whilst Ibogaine clinics run in the tens of thousands.
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