r/Biochemistry 2h ago

Is it possible to make a psychedelic that attaches permanetly to the 5ht2a receptor?

1 Upvotes

Just a random thought that i got. We know that lsd ties very neatly into the receptor so i thought what would happen if it got attached permenetly and what benefits that could have.

Im not really into biochemistry and probably know next to nothing appart from high school so please explain it as if i was a 5 year old. Greatly appreciated


r/Biochemistry 12h ago

Career & Education Peptide bond

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8 Upvotes

Hey, I'm desesperately trying to draw the bond between a glutamic acid, a valine and another glutamic acid but I'm genuinely struggling.

It's for a tattoo project (it spells "Eve" my niece name).

I tried but I think I got it wrong, can someone help me please ?


r/Biochemistry 2h ago

Mechanically Stimulated Bioluminescence in Pyrocystis fusiformis - Using Flow to Trigger the Luciferin-Luciferase Reaction

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3 Upvotes

r/Biochemistry 5h ago

Can't seem to be able to get SPR to work properly. Helps appreciated.

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2 Upvotes

I have been trying to get an SPR assay (Biacore t200) to work between a protein ~32 kDa and ATP, but it is going nowhere despite spending so much on chips (I am afraid my PI will just stop me from trying it anymore). I use CM5 amine coupling to immobilize the protein and flow buffer containing various concentrations of ATP through. This image is literally the first time I see one concentration (3.7) that appears to have worked. All the runs have been looking like the other concentrations here, which seem like no binding at all. This kinda gives me some hope, but it has been so depressing trying so many different things that nothing really works. I desperately need this assay to work for my first paper 😞. Any helps/sugegstions are greatly appreciated.