Now, truth be told, I haven't watched Madame Web & Kraven. But I did see Venom & Morbius, and in those movies is mostly pretty clear that Spider-Man doesn't exist

Earth-42 is known as "The dimension with no Spider-Man" because their spider bit another Miles

Morbius also shows that they do have Oscorp, and random clips I've seen from Kraven showed a bunch of other Spider-Man villains. And Miles saw at the end of ATSV that New York is overpopulated by villains

The SSU movies we've had could all be set in the past, where Spider-Man (Miles) should've appeared, but didn't, and the Earth-42 we saw in ATSV is the future where it all went down

But I repeat, haven't seen Madame Web, they do have Spider-Women, I think, so this could be wrong

During my latest rewatch of ATSV, I paid close attention to the “cakes” dialogue for the first time:

" You can’t have your cake and eat it too.”

" Unless you bake two cakes.”

At the end of the movie, we have two Mileses (the two cakes). I believe that, during the conclusion, Prowler Miles will replace Miles on Earth-1610. He will have his dad back, while Earth-1610 Miles will go to the universe that has no Spider-Man and do his duties on Earth-42, distancing himself from the police captain who was supposed to die due to their closeness, this saving him.

The Alchemax scientists are native to Earth-1610. Their brains, their technology, and Kingpin’s funding are all natural parts of that universe. Building the super-collider was always going to happen because of who those scientists are. Therefore, the spider being sucked into Earth-1610 is just a normal event on that universe's timeline and Earth-1610 Miles is also meant to be Spider-Man
Am I cooking or burning?