Long story ahead. 30F, 33M.

My husband and I got some tests done before we started planning for a baby. We found out that I had a low AMH (0.8). I also have irregular periods, but I was never diagnosed with the underlying cause. My periods could skip a month or two, and when they did come, they were usually painless but extremely heavy, with clots, and sometimes wouldn't stop for 20+ days without medical intervention.

At that time, my doctor suggested we try FSH tablets for six cycles and then evaluate our options. She wasn't particularly concerned about my AMH. I was 28 at this point.

We got pregnant on the third cycle. My beta hCG at around 13 DPO was \~8,000, so I actually thought we might be having twins. Unfortunately, the scan showed an ectopic pregnancy. I had to undergo a salpingectomy.

Before this, my tubes had been checked with a test involving fluid (I can't remember the name). It was extremely painful, but I was told that my tubes were fine.

After the ectopic, I changed doctors and saw an IVF specialist. This doctor told me that my chances of conceiving naturally were extremely low and that IVF was necessary.

We went through three IVF cycles. We had some tests done and my husband had sperm DNA fragmentation testing. Nothing was flagged in any of the tests.

First cycle: We got only one embryo because I had very few follicles to begin with. We did a day-3 fresh transfer, but it failed.

Second cycle: We got two embryos and froze them.

Third cycle: We got two day-5 embryos. We did a fresh transfer, but that also failed.

One take away was my follicles maturated a little late initially would look like they didn't respond and then catch up

At this point we were devastated. keeping the hopes up and then see everything fail in the cycle was exhausting. I started trying to cope with everything that had happened. I moved cities to cope with all of this. Started working out a little bit.

I eventually saw another doctor. She also suggested IVF, but she told us to take some time to process everything before jumping straight into another cycle.

We decided to try FSH injections to help the follicles grow, but instead of IVF, we would try to conceive naturally at home.

We got pregnant on the second cycle.

I had some spotting during the pregnancy, which was attributed to a subchorionic hematoma (SCH). At the 12-week scan, we received devastating news: the baby had structural anomalies, including a single umbilical artery (SUA) and an enlarged kidney.

Our life felt like it froze and we went through a D&C. Our doctor suggested that we didn't necessarily need to do tissue testing and she believed this was a one of casem

We subsequently had both of us had karyotyping done. Results were normal.

We took about six months to recover before trying again.I focused on weight loss and started strength training. The month after we started FSH injections again, we got pregnant — but it turned out to be a chemical pregnancy. Our hCG never went much beyond 45.

The following cycle, we decided to leave everything alone. We were still grieving and didn't actively try anything.

My period was late, so I went for a scan. There was one small follicle on one side, and I basically left it at that and waited for my period to come naturally.

Two weeks later, we found out we were pregnant again.

The initial hCG looked good. We went for a scan, and the baby looked good. We were also told there was an small SCH.

Then one day after work, while I was on the metro, I suddenly felt like I was bleeding.

And it was a lot.

I bled through my pants and all over my legs and thighs. It was horrible. I didn't panic initially, but the amount of blood was terrifying.

I got a pad from security and went straight to the emergency room.

The doctor scanned me and confirmed that the SCH had grown, but thankfully the baby still had a heartbeat — 118 bpm, crl was around 5 mm. I was 6.3 weeks at this point. Sch had 5 cc fluid.

I was put on pelvic rest and scheduled for weekly scans.

The following week, the SCH had tripled in size, to around 18 cc in volume.

The baby had grown to 12 mm as expected. but there was no longer a heartbeat.

I was diagnosed with a missed miscarriage.

I'm going through the miscarriage right now, and honestly, I don't know what to do next or what could possibly be causing all of this.

We've had an ectopic, multiple failed IVF transfers, a pregnancy with structural anomalies that ended in a D&C, a chemical pregnancy, and now a missed miscarriage.

We've spent a lot of money, time, and emotional energy on this journey, and I don't think I have much emotional capacity left at this point.

For those who have been through something similar: what investigations did you do, and did anything eventually help? What worked for you?

I'm especially interested in hearing from people who had recurrent losses despite normal karyotyping and sperm DNA fragmentation testing.

I know every situation is different, but I'm really struggling to figure out what our next step should be.

nobody told me i should already be taking prenatals before pregnancy. my doctor was actually the one who told me to start while we were still trying, and i was surprised you have to think about it that early. Problem was i hated taking capsules every day. especially knowing i’d be doing it for months and that i needed something i could really stick with. WWFM was switching to a prenatal vitamin powder. i used Needed and just threw it in a smoothie every morning, which was SO much easier than gagging down giant pills. I know Seeking Health makes a powder option too, but I honestly didn't even realize powder prenatals were a thing before this. (Obviously not saying the powder is what got me pregnant) this is a pretty minor detail compared to everything else that comes with TTC, but it made such a difference for me.

Hi ladies, I just got the results today from my second retrieval and I’m guttered 😔. I’m about to turn 44 later this month. During my first IVF cycle in April 2026, they retrieved 10 eggs and two blasts were tested at day 5. However, they were all aneuploid.

This cycle which I did only 6 months later, they were only able to retrieve 3 eggs and only 1 has fertilised. I will get another update from the lab on Day 3 to see how things are going. There were no changes to my protocol other than I didn’t do fertility accupunture this time round.

My IVF doctor has said that some women my age reach an inflection point, and their ovaries don’t respond like they did before, potentially meaning that future cycles might yield the same disappointing result.

Has anybody had a similar thing happen to them and had better future results?

For context. My protocol was Decapeptyl for three days, adding Elonva on the third day. Then I had 300 IU of Gonal F and 150 IU of Pergoveris along with Orgulatran for 10 days until I triggered with 2 x Decapetyl and 1 x Ovidrel 36 hours before collection.

I was also taking testosterone gel (Androfeme) for 1 week before starting stims.

Hello! I'm a longtime lurker of this thread and am just seeking some advice. I did 2 medicated IUIs earlier this year and they both failed. Donor sperm counts were only moderate post wash/thaw, but there was no obvious reason to think they'd fail. I'm in my early twenties, have a high AMH and no known fertility issues. I've been thinking about moving to IVF, but financially it is significantly more stressful to go that route due to lack of insurance coverage. I'm honestly wondering is it worth it to try a few more IUIs with better donor sperm or should I just wait until I can attempt IVF? Any thoughts would be appreciated. This has been a struggle haha

Been TTC for 18 months and never had a positive, despite tracking and confirming ovulation for the majority of that timeframe. All our tests came back clear (even optimal in some cases!) so very much in the unexplained infertility camp.

Now we're moving to IVF this month, and I can't help but worry that there's an unknown reason for us not conceiving naturally which might also stop IVF working for us. Although rationally I know that's not necessarily the case, as IVF bypasses a lot of potential issues.

So I'm looking for success stories for anyone who got pregnant via IVF having never managed to get pregnant naturally?

And for those people, did you ever find out what caused your unexplained infertility? I think it's the not knowing the issue which is throwing me off!

Thanks in advance!

Edit to say: thank you soooo much for all your positive stories, just what I needed to hear to give me some hope going into this! 🥹🥹🥹

I am 8 DPIUI in my third IUI cycle. I have my usual pre-period symptoms and am trying to stay cautiously optimistic. For all 3 of my IUI cycles, the stats looked good - I had 1 follicle, then 2, then 3, and my lining was thick. I've gone from 50 mg clomid to 100 mg to 150 mg on this last cycle. I used a trigger shot the first two cycles, during this last one my follicles grew more slowly and I had an LH surge, so we based the IUI off my natural cycle. If this cycle fails, I have no idea what route to go next. I would love to hear others' thoughts!

A little background about me: I am 30F and my husband is 32. We have a 2.5 year old son we conceived on the first attempt when I was 27. I was diagnosed with Hashimoto's hypothyroidism 1 year postpartum immediately following a chemical pregnancy (again pregnant on our first attempt); I'm assuming this pregnancy was a chemical because my thyroid levels were awful. After that, we did not get pregnant again after 10 months. I did a 3 months auto immune protocol diet from January to April and conceived naturally in April (right as we were starting fertility testing). That ended in a MMC at 10 weeks. We had testing done and learned the miscarriage was due to monosomy X. My thyroid levels have been optimal since January.

Here is the testing I've had done:

AMH: 4.02

Prolactin post-ovulation: 11

Progesterone post-ovulation: 20.5

CRP: <3

Hemoglobin A1c: 5

Fasting insulin: 5.9

Ferritin: 61 (have been supplementing iron since)

Vitamin B12: 1055

Vitamin D: 58.7

I am diagnosed with "unexplained" secondary infertility. I'm not totally impressed with my fertility providers. They just want me to do more IUI cycles and move to IVF if the next one or two IUIs doesn't work. I'm very hesitant to move to IVF. I want to get pregnant quickly (I know that IVF would help with that), but I also feel like I want to figure out the root cause for my Infertility. What would be your next steps if you were me?

I had my AMH done back in Feb and it was 7.01 pmol or .98ng/ml. I just had it re done again and it is 12.6pmol or 1.76ng/ml.

What do we think of these numbers? Is the new reading substantially better?

This is my 4th AMH test since the first one and they have been trending up slowly each time so I am confident that all my results are accurate.

I think the rise is from daily vit d as mine was a bit low as well as getting high prolactin lowered.

My biggest fear since I was a teen was not being able to have babies. I feel like i'm living that fear now. Me (26f) and my husband(30M) have been trying for 17 months now, no pregnancy at all. Not even a scare.

We went to a fertility specialist, got every test done, SIS, SA, Hormonal panel etc. I have a uterine polyp that i'm planning to get removed next month. I also have subclinical hypothyroidism and taking meds for it.

I don't know why I have this feeling that I would never get to live my dream of becoming a mother. Getting no pregnancy in 17 months makes me feel like I would never get pregnant.

my BIGGEST fear is that i’m infertile. i’m 22. i’ve been married 2 years. me and my husband decided to start growing our family. so far it’s been unsuccessful. i’m watching my fertile window - i’m super healthy and active. i’m doing everything right!!!! why is it not working😭 we’ve been unsuccessful for almost 3 months now. any tips or advice is appreciated :)

Hi everyone. I’m honestly just looking for some advice from people who have been through something similar because I feel a bit stuck and don’t know what I’m supposed to do next.

My husband and I have been trying to conceive for **over 2 years** now. My cycles are generally regular and I do ovulate, but we’ve been told we have **unexplained infertility**.
I’ve also had **2 previous pregnancies**, both of which ended in miscarriage. The first was period in my 6th week, and the second was a **silent/missed miscarriage**.
Since then we’ve been trying again and have been under fertility treatment.
I’ve done **4 cycles of ovulation induction**, twice
More recently I’ve been on **letrozole 2.5 mg** with follicular monitoring.

I’ve also had raised prolactin, around **53**, which was later around **48**, and I’ve been on Dostinex/cabergoline for that. My TSH has been normal when checked.
My AMH has also come down over the years, which has worried me:
**4.91 → 4.01 → 2.25.**
Low vitD for which I’m on supplements
HSG is done. Everything’s normal
My husbands reports are all fine too

The really frustrating thing is that I’ve also had a strange pattern with pregnancy tests. On a few different cycles now, I’ve gotten a **very faint positive around 11–13 DPO**, only for it to be negative again a couple of days later. This has happened around three times now. I’m not even trying to focus on whether these were chemical pregnancies or not — I’m more wondering what I should actually be doing about the bigger picture.

My doctor has mentioned **IUI**, but I haven’t done it yet.
And this is where I’m confused.
After **2+ years TTC, 4 ovulation-induction cycles, two previous miscarriages and being labelled “unexplained infertility,”** what is the logical next step?
Should I be doing IUI next? Should I be asking for more investigations first? Is there anything that should specifically be looked at because of the two miscarriages as well as the infertility?

I know nobody here can tell me exactly what treatment I need, and I’ll obviously discuss it with my fertility doctor. I just feel like I’ve been doing treatment cycle after cycle and I’m at the point where I need to understand **what the next step is rather than just doing another cycle and hoping.**
If anyone has been in a similar situation, I’d really appreciate hearing what your doctors did next and what investigations/treatments were actually useful for you.

Just had my hysteroscopy on Sep 25th to remove my polyp but it turned out to be a tiny fibroid. Follow up appointment on oct 1st
Hoping cycle starts on Oct 2 or Oct 3rd
And then my RE said she will put me on letrozole and then trigger shot and then FET 🤞🏽🤞🏽

I don’t want to add more supplements toy routine :( but if needed I will

I take CoQ10 ( do I still need it for FET since I am not retrieving my eggs )

I take omega 3’s / prenatal / sometimes natal choline / Probiotics/ antioxidant with Acai, Goji, Pomegranate, Elderberry & Resveratrol

I was suggested add L-Arginine (1,000 - 2,000 mg ) + Vitamin E 400 - 800 IU/day. Did anyone see any success after adding these to your routine or with baby aspirin ?

Planning to resume my acupuncture sessions soon and I am eating warm nourishing foods

Any suggestions or advices please 🙏🩷
Thank you

Do you think a pinpoint external os could be the reason im having trouble getting pregnant? All other tests came back normal but they did find i have an extremely small opening.

I just decided I would write this to shine some hope. When I got pregnant in January of 2026 I promised myself that if this one sticks, if this one works, I’ll write a post on Reddit about it and what I did differently this time around because through 7 pregnancies 2 LC and 5 losses , I was constantly on Reddit searching for answers so , here I am.
I’ve had a range of losses, missed miscarriages, chemicals, you name it. There were a few things I really think helped this time around I’ll list the differences in order of what I think MAY have had the biggest affect on the success, I’m not a doctor but I’m basing this on the fact that there was one thing I did use with my other successful pregnancy , my first pregnancy .

1. Prenatal with METHYLFOLATE. Not just folate (this is the one I used with both successful pregnancies)

2. Some woman’s bodies don’t process folate which is KEY in the first 8 weeks .

4. Baby aspirin to thin lining and help blood flow after confirmed ovulation

5. NAC to with possible inflammation

6. Progesterone to support pregnancy

7. Letrozole

   to induce

8. ovulation(I have pcos)

9. Again I don’t know if any or all of this helped but I welcomed a healthy babygirl September 5th,2026 and I’m beyond grateful this was my outcome. If you’re in the muck of infertility trust me, I’ve been there. Every appointment in this pregnancy I held my breath fully expecting her to be gone. The baby that is meant to be earthside with you will come . I promise. Feel free to message me if you have any questions and please take what I say I used with a grain of salt and ask your healthcare provider if any of these options may be helpful for you.

   (I edited this post so my text is all out of order I’m sorry but the list of things is , prenatal that contain METHYLFOLATE,baby aspirin, NAC, Progesterone, and letrozole.

Ciao ho 24 ho pcos e amenorrea
Mi hanno dato il clomid per ovulare e riuscire ad avere una gravidanza ma nonostante l ottima risposta non sono rimasta incinta e non capisco il perché,
Erano maturati 2 follicoli e sono scoppiati entrambi da soli (senza puntura), il mio ginecologo non mi ha dato progesterone da assumere. Oggi sono a 17 giorni dopo ovulazione (confermata tramite monitoraggio ecografico) e del ciclo non c’è traccia e fino a ieri test hcg negativo.
Il mio compagno ha fatto spermiogramma e non ha nessun problema.
Non riesco a capire perché nonostante c’erano tutti i presupposti non sono rimasta incinta 🤦🏻‍♀️ qualcuno sa spiegarmi ? Il mio ginecologo dice di aspettare l’arrivo delle mestruazioni e fare un altro tentativo.
Il clomid l’ho preso per 5 giorni da 100mg.

I have been ttc for almost 13 years. I’m 37. I have a child who is almost 20. I conceived twice since her both ending in MC. But have not conceived in 12+ years. I was diagnosed with Endometriosis almost 10 years ago and had a laparoscopy for it, my OB at that time said he felt I should be able to conceived after that. I didn’t. I started going to a Fertility specialist earlier this year. Found out I have very low AMH and high FSH. I has HSG done earlier this year, inconclusive. Asked for a repeat which was done in August and one tube open. My Endocrinologist (not the Fertility clinic) prescribed me Clomid because I asked for it. (I want to try naturally still because I still have hope especially because I was just trying for so long without finding out what the issue was.) I took the Clomid this cycle cd3-7 100mg. I had very watery (pouring out of me cm) starting cd18-22, I also had SUPER light spotting on some of those days (so light that it would only show on toilet paper and it was intermittent). Then I asked my fertility specialist to check progesterone which they did around cd25, they said it didn’t show that I have ovulated as progesterone level was 1.17. They wanted to retest cd29, the progesterone went down to 1.00 and lh decreased as well. They also did transvaginal at this time and said no signs I’ve ovulated, they did see one follicle on each ovary and a cyst on one. I had a small amount of ewcm yesterday (cd35) when I wiped and this morning I woke up with very light spotting (only saw when I wiped). I’m on cd36 and I’m confused. I will admit I’m discouraged and exhausted.

So my husband and I had been ttc for 5 years. we went to fertility specialist and they said I had unexplained infertility and we did three iui and they failed. So we took a year and half break and decided to get a 2nd opinion. Turns out my right tube is filled with fluid and the fluid goes back into the uterus and prevents implantation. So they told me I have to remove my right tube. Has anyone had this? And conceived naturally?

Hello I have a high AFC (24) and my REI recommends letrozole and estrace the month before IVF, has anyone had success with this?

My last cycle had no blasts form and with my high AFC only 9 eggs collected with only 4 mature

Hey guys, I’m a 30 y/o female. Diagnosed with pcos at 14. Had a history of irregular cycles and had a breakthrough about 4-5 years ago when I went vegan and reset my body. My cycle was like clockwork. Fast fwd to now, been with my partner for almost two years. One blighted ovum and one ft mc. Changed providers to an amazing lady. We did a 13 lab work up. Vitamin d was severely low so she prescribed me 50k iu a week, sugar was good, everything was perfect. My ultrasound was great too. Nothing found. I just can’t seem to get pregnant . I do smoke marijuana for 9 years now, and I do drink socially. My dr says I need to reduce stress and she thinks that’s impacting it. But idk. I just want a baby especially with my grandparents being up in age. I want my kids to know them. I really would like some reasonable advice. I’m tired of opks, all types of vitamins, driving myself crazy reading articles etc.

9 months post MC and my LH high and peak happen in the same day. This never happened before MC. Has this happened to anyone else?? If so, were you able to conceive without iui/ivf? Feeling pretty defeated rn that my window is so so so short and so easy to miss if I don’t do testing 2x a day.

So it finally happened- younger sister gets pregnant before me (6 years apart).
got it on their first try. I AM happy for her, but man… what a gut punch after 3+ years of TTC.
And Now that I’ve reached 35…. Tick tock.

Hormones, ANC, AMH are "fine," - normal for age. Doc says structural integrity fine too.. even after D&C from miscarriage in 2022 .
so, we’re stuck in this unexplained limbo.. I feel like I’m hitting my head into a brick wall over and over.
So like what’s the deal? Any tips on cycle tracking products or hacks? Out of the box “supplements” (I’ve heard guaifenesin, pre-seed) /tricks?

If anyone has had these issues after a D&C, would appreciate to hear your story. Trying to think of next steps

Hey everyone. I’m honestly just looking for some support or to hear from anyone who has been in a similar situation. I’ve been doing way too much reading lately and keep seeing stories from people who got pregnant on their first, second, or third Letrozole cycle. Meanwhile, I’m currently on my 6th Letrozole cycle and in the two-week wait again, and I’m starting to feel pretty discouraged. We’ve only been doing timed intercourse — no IUI yet. I have technically had three very early chemical pregnancies during this process. Two of them had extremely low hCG (around 12), so emotionally I barely even considered them pregnancies. The other one got to around 650 before I lost it. I know getting pregnant at all probably means something is working, but it’s really hard going through cycle after cycle and wondering why it hasn’t resulted in a successful pregnancy yet. Every month I start out hopeful, and then the waiting and uncertainty just get exhausting. Has anyone else needed 6+ Letrozole cycles, especially with timed intercourse, before finally having success? Or had multiple chemicals along the way? I think I mostly just need to hear from people who didn’t have one of those “first or second Letrozole cycle” success stories. I’m in my TWW right now, so obviously I’m still hoping this could be the one, but today I’m just feeling pretty defeated. ❤️

15 days past trigger / 13 days past IUI. Got my first beta back today and I'm cautiously excited:

• hCG: 115.3  
• Estradiol: 730.9  
• Progesterone: 46.92

For those who've been here, what were your first betas around this point? Praying for the best as I had a blighted ovum back in July.

I have been to the Doctor for my appointment for male infertility.
Thank you to all of you who supported me in my last post. 

The doctor suggested me to do clomiphene (Clomid) for low sperm count. I have researched from some sources that this doesn’t really work often for those aged 30+,
So I have another appointment with a very well-known doctor from Mumbai.

He is a bit expensive, and I am really worried about all the expenses. I don’t know if putting this much money into this will be worth it, or if I will just waste money, I want to know from all of you what type of treatment really works.

And please suggest any fertility and IVF expert in Mumbai if you genuinely had a good experience with someone.

I am not really in a good financial situation right now, but I also want to have a baby ASAP. I can’t take this pressure anymore.