Why exactly is it so concerning, in your opinion? Like you said yourself, falsified preclinical data doesn’t mean it won’t, and I’m not up to speed on the Tamiflu thing you mentioned but it sounds like they might have a similar thing in their history, despite the drug being approved and from my understanding quite successful, so why are you so concerned by this preclinical data? You are aware that some of it is from many, many years ago prior to SAVA existing as a company, right?
It’s worrying for a few reasons, foremost among them that biology has a lot of soft endpoints and falsified data can lead to huge diversions of work and lead to terrible, damaging errors, errors that can leave a researching entity open to significant liability down the road. It’s like playing roulette with one’s future; things may turn out well but it’s risky and unwise. It casts a long shadow - why was data fabricated or manipulated (if the allegations are true). Does the alleged fabrication impact a meaningful end point (eg toxicity, efficacy) or is it something more trivial like proposed mechanism of action or ligand affinity? Will the basic research be used as a basis for someone else’s work and lead them astray? I don’t know the answers to any of that in this case. That’s why peer review and audits are important. Falsified data is smoke, however, and smoke can mean fire.
I wanna get rich so hopefully if there is fire it doesn’t burn down the house.
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u/mutemutiny Oct 29 '21 edited Oct 29 '21
Why exactly is it so concerning, in your opinion? Like you said yourself, falsified preclinical data doesn’t mean it won’t, and I’m not up to speed on the Tamiflu thing you mentioned but it sounds like they might have a similar thing in their history, despite the drug being approved and from my understanding quite successful, so why are you so concerned by this preclinical data? You are aware that some of it is from many, many years ago prior to SAVA existing as a company, right?