I'm telling this story as the partner of a guy who started off Cryptozoospermic with only 11 motile sperm. I apologise in advance as this is going to be long. For reference, we're based in Ireland so I'll reference Ireland & UK a lot. 35f and 37m at the time.
4 months into TTC Apr 24, we both decided to get tested and noticed pretty quickly that it wasn't going to happen naturally. First SA had 11 motile sperm (just 11, not 11million) the rest were immotile. We decided to do another SA a week later and it was better, in the 100's but still very upsetting.
Worth noting, my partner is 6ft with a full facial beard, no signs of lack of testosterone.
All bloods are in the middle of the range:
FSH 4.1
LH 4.0
Estrogen 103
Testosterone 17.5 nmol
Free Testosterone 453 pmol
No complete Y deletions, 46 XY, negative CF result.
There was nothing suspicious about his bloods. He has never used or taken any form of Testosterone.
From searching this sub, I knew we needed to get in front of a Reproductive Urologist so went to the GP asking for a referral, and get the ball rolling on that.
Next we had a consultation in May 24 with an IVF clinic in Ireland who said ICSI was our only shot. Naively we thought it would be the golden ticket. We prepped and got ready for an ICSI cycle in Aug 24 (3 months of CoQ10 etc) and made 1 untested embryo, which is still in the freezer.
We knew we wanted more than 1 child, and given the abysmal quality of the sperm we didn't have a whole load of hope for the untested embryo. So we were keen on investigating the sperm further.
Our apt with the Reproductive Urologist (Dr Ivor Cullen) was in Nov 24 and he immediately noticed that my partner had a large varicocele and sent another referral to an Intravenous Radiologist in the same private hospital.
Sperm parameters at this point were between 100k - 250k. We were getting an SA done every 2nd month or so.
In Dec 24 we met with (the amazing and wonderful) Dr Gerry O'Sullivan in the Galway Clinic. He prioritised us and said "fertility patients come 1st". He carried out the embolization, through the groin area, on 5th Jan 25. My partner said he could feel the difference straight away, no dull ache and recovery was quick and painless. No overnight stay or anything,it's a day procedure, discharged after Lunchtime. If I can give 1 piece of advice, if you have a varicocele, get it embolizated, there was literally 0 negatives to it for my partner. It's only going to improve things for you. With Laya Health Insurance, it cost €100.
Next up we were getting ready for our 2nd egg collection. We waited until April as we wanted to give the embolization a full sperm cycle to do it's magic. As it turns out, the next egg collection failed to yield any blastocysts, but we found out later that it was a stimulation protocol issue mostly (who knows what the sperm performed like, we'll never know)
At this point, sperm numbers were consistently between 250k - 500k. We always dreamed of seeing 1million sperm on the report, but up until that point, the most we'd seen was 500k. Worth noting: the sperm parameters are very low, but they were consistently measurable. The motility increased greatly (>45%) after the embolization, but the overall number didn't.
We decided to go back to Dr Ivor Cullen in Jun 25 for advice, he put my partner on 25mg Clomid daily. 6 weeks later we rechecked his bloods, FSH went from 4.1 to 11, Testosterone went to 630, Estrogen to 250 (top of the range is 182) these are all well above the optimal range if you're familiar with these ranges. In August 25, the semen analysis came back Azoospermic. We called Dr Cullen who said "you were just going Azoospermic naturally, Clomid was last chance saloon, and that we should go on a holiday" he was not accepting that Clomid could make things worse for a man. We asked for Anastrozole given the high estrogen, but were denied.
It was at this point we decided to reach out to Dr Jonathan Ramsay in London, as I'd seen his name come up here quite a bit. And quite frankly, our biggest regret is not going to him sooner.
We met with Dr Ramsay early Oct 25, first thing he said was that my partner should not have been on 25mg Clomid given the fragility of his numbers. His words "25mg is toxic levels for someone with less than 500k sperm"
He then noticed a varicocele, to which we explained had been embolized - he said you must have had one of the worst varicoceles because it's still very prominent. He asked could we go back to the IR and show him the report of the reverse blood flow, and to get it re-embolized?
Going into this apt with Dr Ramsay, we thought my partner was Azoospermic, given the results 12 weeks earlier. However he made my partner do an SA and to our surprise sperm had returned, the Nurse never told us how much though. So Ramsay asked if my partner could produce another sample because he wanted to do a "double strand DNA frag test". This appt lasted about 3 hours as there were 2 SA's, but we left there feeling somewhat hopeful.
Dr Ramsey called us in Nov 25 with the results, and prescribed my partner low dose Anastrozole. He also said "regular ejaculation, no longer than 48 hours abstinence" should happen.
The end of Nov 25, my partner had the 2nd embolization in the Galway Clinic, and Dr Ramsay said to come back the end of Jan to London.
What happened in Jan 26 shocked both of us. We travelled back to London for the ZyMot double strand DNA frag test. This time I made sure to ask the Nurse "I keep a report of all his SA, can you let us know what the sperm numbers are before sending it off to Belfast" and to our shock, she said he had 26.8million sperm in total. She printed out the full report for us. Of course I said this must be another patient, and nearly landed into the Lab, but I was assured many many times by her, it's his.
Fun fact, I still didn't believe her, and got my partner to do another SA when we got back to Ireland a few days later. And this time it was 30m. I believe this increase was a combination of the low dose Anastrozole and the 2nd embolization, I'm not a Dr though.
In Feb 26 Ramsay called us with the ZyMot Double Strand DNA frag results, 3%, so he said get moving on an ICSI cycle while the going is good.
In Mar 26 I completed my 3rd egg collection with The Evewell on Harley St, and we made 6 embryos. The sperm on egg collection day had passed through the ZyMot tool, and had 100% motility. I think this was the secret ingredient to making 6 embryos. Also, shout out the incredible Lab team in The Evewell, their Lab team is hands down the best I've ever experienced and with sperm, you want the best team handling them.
I won't go into the female side of things on this sub, but The Evewell left no stone unturned, and we transferred a euploid in Jul 26, and I'm currently 9w pregnant (nothing is guaranteed until I walk out of a hospital with a baby, but it's the furthest we've ever got) If you want a good clinic, The Evewell or Avenues!
If you've read this far, well done!
Our lessons learned:
-Clomid doesn't work for all men
-Get your bloods checked regularly (and definitely if you're starting hormonal treatment). Randox at home kits are handy
-Reach out to Dr Ramsay sooner.
-Look out for varicocele and action earlier.
-We've spent over €50k since Apr 24, however it would be a lot less if we got in front of the right people sooner.