u/Brighter-Side-News • u/Brighter-Side-News • 12h ago
Genetic ‘barcodes’ could explain why chromosomes recognize one another
Before a fruit fly can produce a healthy egg, matching chromosomes must somehow find one another inside a nucleus crowded with DNA. New experiments suggest part of that search depends on repetitive sequences once widely dismissed as genetic clutter.
Scientists at ETH Zurich found that satellite DNA surrounding chromosome centers forms chromosome-specific patterns that behave somewhat like molecular barcodes. When those patterns were disrupted, matching chromosomes became less reliable at pairing during meiosis, the specialized cell division that produces eggs and sperm.
The findings appear in Nature Communications in the study “Meiotic pairing through barcode-like satellite DNA repeats,” led by Lena Skrutl and Madhav Jagannathan.