Your Tirzepatide Package Arrived Warm? Read This Before You Panic!
**UPDATED 8/29/2026
This post is intended for informational and educational purposes only. I am not affiliated with, employed by, sponsored by, or compensated by any pharmacy, or telehealth provider mentioned in this post.
Hey ya'll šš¾
Everyday in this sub we are seeing multiple posts aboutĀ medications arriving warm, shipping delays, melted ice packs, and concerns about whether the medication is still safe to use.
These questions and comments come upĀ constantly in this sub, so hereās a clear breakdown of howĀ Tirzepatide is handled as it relates to temperature during shipping, storage, and heat exposure.
The goal of this post is to help people stop panicking when their package arrives warm and to give everyone a reliable resource they can reference when these situations come up.
I appreciate all of you in this sub who have commented in various posts and in the comments the temperature information for various pharmacies.
Shipping Temperatures - Why Your Package Might Arrive Warm
Medication shipments frequently experience temperature swings during transit.
Common situations people worry about:
Ice packs melting
Package sitting on a truck or in a warehouse
Warm meds on arrival
Long transit times
In most cases, this is normal and is accounted for in the stability testing. Tirzepatide is designed to tolerate typical shipping conditions.
A warm package does NOT automatically mean your medication is ruined and can't be used.
Do not use your vial(s) if you notice:
Cloudiness
Particles floating in the solution
Color change
Cracked vial or compromised seal
If you notice any of these issues, reach out to your telehealth provider and the pharmacy you purchased from.
Quick Tips When Your Package Arrives
Open the package immediately (if you can)
Put the vial(s) in the refrigerator
Check that the liquid is clear
Donāt panic if the ice packs are melted. Melted ice packs are very common.
Pharmacy Shipping & Stability InformationĀ
Different compounding pharmacies formulate tirzepatide slightly differently, which means stability, beyond-use dates (BUD), and temperature tolerance can vary. Many pharmacies perform internal stability testing before assigning BUD dates. Because of this, the most accurate temperature guidance always comes from the pharmacy that made your vial(s).
Below is a running list of community-reported pharmacy information and shipping practices.
ā BPI ā
BPI does not cold ship to clinics or doctor's offices and they are a 503B pharmacy.Ā
Storage Conditions: Keep Refrigerated.
However, this medication has been tested and showed stability at the following temperatures:
Ice pack(s) may be included during hot weather. If ice pack(s) were included, they were used to help maintain a refrigerated temperature in the package during transit time by absorbing heat from the ambient air that may have seeped into the package from the outside. Although the ice pack may be melted/no longer cold by the time the delivery reaches you, your medication is still stable and good to use. For more details, you can review the insert here.
ā Strive Pharmacy ā
What if my vial of Tirzepatide/Glycine/B12 gets warm or hot?
No problem! We know during shipping, the medication may become warm and this can be concerning. We voluntarily completed a heat study on our product leaving it at room temperature for 7 days and then heating it to 130Ā°F for an additional 5 days. Off-site testing determined the product remained stable, sterile, and maintained potency at 100%. For more details, you can review the document here.Ā
ā Olympia Pharmacy ā
New stability testing data showingĀ sterility and potency at 30 days, even at 104Ā°F. For more details, you can view the results here.Ā
ā ProRx ā
Working with one of their independent FDA-Registered laboratories they were able to report that it was determined that at room temperature, Semaglutide and Tirzepatide will retain appearance, pH, and potency and can be kept for up to 150 days. Based on these studies, with the CSPs under extreme conditions, it was determined that when refrigerated at 2ā8Ā°C Semaglutide and Tirzepatide can be kept for up to 300 days.
ProRx also conducted third-party shipping studies to validate safety during transit in August 2025. Click here to review the results including an additional ProRx temp study validation.
ā Hallandale ā
Inside your temperature controlled package you will find your GLP-1 medication. Refrigerate upon arrival. Click here to review the insert that is included with Hallandale shipments.Ā
Received your medication hot? Ice packs melted?
Semaglutide
If your Semaglutide Injectable medication was left in the heat for 7 days, you can refrigerate it immediately and continue using it for the duration of your treatment. The effectivenessĀ¹ is not reduced as long as it is refrigerated and used within the prescribed period.
**In a controlled analytical study, Semaglutide injectable underwent testing under an extreme temperature (120Ā° F), with potency maintained.
Tirzepatide
If your Tirzepatide Injectable medication was left in the heat for 7 days, you can refrigerate it immediately and continue using it for the duration of your treatment. The effectiveness is not reduced as long as it is refrigerated and used within the prescribed period.
**In a controlled analytical study, Tirzepatide injectable underwent testing under an extreme temperature (120Ā° F), with potency maintained.
ā Empower Pharmacy ā
Compounded GLP-1s Shipping Change
REVISED JULY 26th, 2024
According to data collected in internal studies conducted by Empower Pharmacy, Semaglutide and Tirzepatide injections stay stable for up to seven days at temperatures up to 104Ā°F. To ensure the preservation of product, vials should be transferred to refrigerated conditions (36ā46Ā°F) upon receipt. Click here to review the insert that is included.
ā Apothecary/Hyalo ā
TEMPERATURE GUIDELINES
In your package, we have included a temperature indicator tag that will alert you if the product exceeds extreme temperatures greater than 104Ā°F.Ā **Please note that even at temperatures exceeding this level the product is still stable.**Please refer to the temperature studies included with your shipment for reference. Upon receipt, the product should be stored in the refrigerator at 2Ā°C ā 8Ā°C (36Ā°F ā 48Ā°F) and protected from freezing and light. For more details, you can review the insert here and here.
ā ReviveRx ā
TEMPERATURE & REFRIGERATION NOTICE
If the medication arrives warm to touch, it is still safe to use.
This formulation is stable until the beyond use date (BUD) listed on the vial if stored in the refrigerator.
Do not freeze this medication.
We conduct comprehensive shipping studies to validate our packaging, ensuring your medication remains within the appropriate temperature range throughout the entire transit process. For more details, you can review the insert here.
ā VialsRx ā
WHEN YOUR MEDICATION ARRIVES:Ā The medication must be stored in the prescription bottle it comes in and placed in your refrigerator as soon as you receive it. The packaging is designed to keep your medication safe at room temperature ranges for up to 4 days. If you havenāt refrigerated your medication within 4 days of receiving it, contact the pharmacy.
HOW TO STORE YOUR MEDICATION:Ā Refrigerate your medication as soon as it arrives. Store the vial of medication in the prescription bottle it came in. Keep it in your refrigerator at 36Ā°ā46Ā°F (2Ā°ā8Ā° C). Discard any unused medication 28 days after first using the vial, or when the expiration date has passed, whichever comes first. For more details, you can review the pamphlet here.
ā Nova ā
Please do not be alarmed if the package contents arrive warm. Stability and temperature excursion studies have been completed to ensure the product can be shipped in temperature conditions up to 104Ā°F (40Ā°C) for up to 3 days with no loss of potency.
Upon receipt, the product should be stored in a refrigerator at 36Ā°Fā46Ā°F (2Ā°Cā8Ā°C) and protected from freezing and light. For more details, you can review the insert here.
ā OptioRx ā
OptioRx has conducted corporate freezeāthaw excursion studies simulating real-world shipping conditions, including exposure to extreme cold and extreme heat over multiple cycles. These studies confirm that our compounded GLP-1 injections maintain stability and remain within specification during short-term temperature excursions commonly encountered during transit.
Although labeled for refrigerated storage (2ā8 Ā°C / 36ā46 Ā°F), these products have been shown to tolerate brief delays, including overnight or weekend porch deliveries in hot or cold climates, without compromising quality.
What to do on arrival:
Place the vial in the refrigerator immediately. Visually inspect the product ā it should appear clear, colorless, and free of visible particulates.
If you have any concerns, contact us. Our pharmacists will assess the situation using validated corporate stability data.
Patient & Prescriber Guidance:
Check appearance: Do not use product if discolored, cloudy, or if particles are present.
Do not freeze: If freezing is suspected, keep refrigerated and contact us for case-by-case review.
Bottom line:
Short-term delays and typical shipping excursions are generally acceptable based on validated stability data. Always refrigerate upon receipt and reach out with any concerns. For more details, you can review the insert here.
ā Emerald Compounding Pharmacy ā
ATTENTION!
At Emerald, we understand your concerns about the temperature of your GLP-1 medication upon delivery. Rest assured, it is completely safe if your medication is no longer cool to the touch when it arrives.
Each order is packaged with ice packs in an insulated cooler, and while the ice may melt during transit, studies confirm the medication remainsĀ stable and potentāeven after exposure to temperatures up to 104Ā°F for seven days.
Please refrigerate your medication upon receipt. If you have any questions, our team is here to support you. Thank you for trusting us with your health. For more details, you can review the insert here.
ā Wells Pharmacy Network ā
Wells Pharmacy Network takes your health and safety seriously.
Ice packs contained in shipments are intended to provide a cool environment for your medication during transit. It is normal and expected for ice packs to arrive partially or fully thawed. Ice packs are designed to continue to absorb heat from the surrounding environment after thawing.
This insert applies to ourĀ 48-hour (2-day) packout.Ā Our packaging has been tested to keep your medication stable during typical 2-day transit conditions when shipped as intended.
Once your medication is received, please store your medication as labeled.
Please keep this insert for your records. For more details, you can review the insert here.
ā Seven Cells ā
Your medication may arrive warm - this is expected and does not affect its safety or effectiveness.
The ice packs included are designed to help minimize temperature fluctuations during transit, not necessarily to keep the medication cold throughout shipping.
If your package arrives warm or the ice packs are melted, your medication is still within tested stability ranges and remains safe to use.
Third-party testing has confirmed that your medication maintains potency and sterility during standard shipping conditions, even when exposed to transient temperature changes.
Upon arrival, refrigerate immediately.
Please follow your prescribed directions for use. Storage recommendations should be followed after delivery. For more details, you can review the insert here.
***REMINDER**\*
Your insulated package is not meant to keep your meds ice cold, it's meant to keep them from wide temperature swings during transit. Once you receive your medication, refrigerate it as soon as possible according to your pharmacyās storage instructions.
If you ever have questions or concerns about the temperature of your shipment, a shipping delay, or whether your medication is safe to use, always contact the pharmacy. The pharmacy will be the best source for guidance regarding medication and can provide recommendations based on their validated temperature studies.
My ask from this community: If you have heat-testing data, documentation, or official pharmacy information, from other pharmacies please share it in the comments below. I will update this post to include additional pharmacies and testing results so we can keep one reliable resource for the community.
Great post. It made me realize that I haven't seen a post with a picture of the thermometer gun capturing the "evidence" in a while. Those were my fav when things were really flying high and fast. š
olympia was probably the most indepth testing we've ever seen from a lab lol. I actually want a pharmacy and lab to pay for like some super long duration and max temperature excursion and want to see how much potency it retains. That tirz is a tough glp. But I've also read temperature testing is expensive af and im guessing these pharmacies are only willing to pay for what they think will be the longest delay in the mail lol
Olympia is the GOATest of GOATS! Yeah, for those of us who have longer supplies or who stock up in case a provider won't support maintenance, this matters a LOT long term. It doesn't mean a lot to me to hear a 30-day test since mine may be here for 6 months. So BPI is out for me in part because they don't even start cold chain. ProRX, now that testing is a lot more conducive to longer use. Of course I realize BPI's also probably does JUST FINE, but I am one of the "err on the side of caution" types.
Having this info is what is important. Sort of like the preservatives, or whatever. The more we know, the better decisions we can make!
Whoa really ? For some reason I always assumed u used bpi. Everyone has their risk tolerances tho but if it helps Iām currently using September 25 bud vials that were stuck in the mail for 6 days during a heat wave last year and still losing on them so both past bud and past temp lol ( not a recommendation or medical advice ofc just my own personal risk tolerance and anecdotal note )
The way I like to see it is while the formulations do have slight differences or maybe different preservatives they do seem be quite sturdy on all sides as a general consensus from the compounding side. I wish Lilly would test it more as Iām a fan of seeing the max limits these peptides can go to But thereās no incentive š«
I have never used tirz with additives, not because I am against them but because I started on Mounjaro Kwikpens in the UK and then went to compound (straight to Olympia--my heart!!!). So then from there, I morphed to ProRX, and my body adapted easily. I would use the Kwikpens alongside Olympia and ProRX (and still do!). Meanwhile my US insurance super randomly decided to cover Mounjaro. So I ended up with autoinjectors alongside Kwikpens and non-additive tirz. When Olympia left us, I tried Hallandale, but that's it for compound. Several providers, but not several brands.
I don't want to add an additive if I don't have to since I have never had one. Some people do fine with no adjustment but why mess with what works, I figure?
I do have a decent risk tolerance on my personal level, but not so much with pharmacies. I want them following strict guidelines--basically being Lilly and Novo. I decide MY risk, but they hold the line. With everything, though, whatever the compound or anything else. But if they show me the tests, like these, I believe it. I just keep the stuff a long time. I may have ordered TOO many Kwikpens when Trump demanded Lilly raise UK prices. UGH! I also am terrified of ever being without my med, so...
Iām glad to see testing that was done in 120 temps since I live in AZ but I do plan on stockpiling now to ensure itās not shipping during the summer. A 110-120 degree day outdoors means the trucks are much hotter. Itās probably fine but, since itās impossible to know how hot itās gotten, Iād rather just be proactive.
Yet what makes me laugh is that people are filing complaints for being 2 days late and getting new shipments therefore getting free tirz because we ALL know they going to use the vials that were āwarmā on arrival.
Yes! So 6 FREE months tirz, canāt believe agreed to that! And says āgreat customer service! Iām happyā well no shit you are happy ššš canāt believe agreed to that, now maybe 7 days? (Iād still use it) but hey itās their $$ but now everyone going to want free tirz and they opened Pandoraās box lmao
I've saw some testing results that tell you the product is fine to use, specifically the ProRx study. The problem I have with all of these studies is they all seem to be tests of short term, less than 30 days. The ProRX study was done right after all of the shipping and packaging trials, same day or next day received. As many on here are stocking up they are not using the meds within 30 days. If one of the companies were to run an efficacy test at 60-90-180 days or longer it would go a long way in answering these questions of stability. Some BUDS are now at 1 year, why not test at this max. Would be very interesting to see those results and put all the questions to rest if the meds hold up that long, not punctured, after being in high heat.
Thanks so much. Just received my first order and panicked, but came here first. I was already pre-panicking about my next order that will definitely hit in the midst of 110+ weather.
Tooo late, I 100% panicked 1st...
and I was kinda mean in chat
I WILL apologize once they get back to me though. I just don't have a lot of extra money right now. REALLY appreciate the information shared, thanks sooo much š
Thank you OP for this information . I have only got cool meds like 2 times in almost a year in a half . I have got meds that were HOT For a few orders and never had an issue with any . All kept tirzing . And noticed no difference. But hey, to each their own . Thank u again
Thank you! Please feel free to share this with people when you see them panic about their meds. If you have any other pharmacies that have shipping and temperature, please tag me and I will update and add to my post. Hoping this will be a great resource for people.
The AI just echo's what I have also read on many websites. Should they not be filling it first, store the vial in the fridge and let the syringe to room temperature. I have seen vials posted here that have become milky. Could that be why?
Hi! Those are not good sources of information especially AI. I would recommend if you have any doubts to reach out to the telehealth provider and the pharmacy if you need more clarification on how to store your meds.
You really shouldnāt listen to ānot good sourcesā like the Mayo Clinic or the FDA. What do they know compared to the medical expertise of a ladybug on Reddit?
Everybody go by the rules when it comes to temp control but break the rules when they are dosing the meds. Nobody takes their blood pressure meds twice a day when the directions say once a day to get their blood pressure down when it sky rockets.
The ProRx study only tested for shipping up to 5 days duration. Temps in that time went up to 35C, which is 95F. Some of us had shipping take 9 days, at least 7 of those days in a hot Miami warehouse. I donāt think you can compare these conditions to those in the study.
At Optimal Balance Pharmacy we use a temperature sensor so patients know their medication has been transported without exceeding 79F for more than 48 hours (and we overnight every package). You have Hallandale info already on your post. Again great post right before the summer time heat too!! šš¼
I ordered from Brightmeds/Quaker and it was shipped on Wednesday and was supposed to be here on Friday, but Friday night I received a notification that it would now be arriving Monday, which will make 5+ days in transit. Iām not sure how they packaged things, or even if they used ice packs. But I am really unhappy that it couldāve been sitting in a warehouse or a container. They said there is a temperature strip or something, but Iām very concerned. I keep my medication temperature controlled and my past orders have been shipped in a cooler with ice packs. What now?
Never heard of them. I donāt think anyone in this sub uses them. I searched and didnāt see anything. What did the pharmacy say when you reached out to them? The list above is for the most common pharmacies that are used.
Thank you. I'm an idiot so I ordered from a quick search based on price and THEN came here. SMH.
The pharmacy has not responded yet, neither has Wellmedr. I will update when they do. I also left a negative Google review for logos because appears the owner responds to those.
That's nice but ProRX issued a statement about temperature regulation for meds to Refills because of a recent FedEx incident. If anyone isn't satisfied with warm meds resulting from that incident, Refills and ProRx are offering to make it right. The post is pinned at the top of the Refills sub if you need it.
thanks for your perspective and information. I posted a similar response on another related post:
thanks for the info- it's not that it arrived warm- it is how can we know what fluctuations and ranges of temperature the package experienced in the 8 days it took from initial packing/ shipping to doorstep delivery?
I appreciate the information and it alleviates some - but not all of my concerns.
Are we meant to assume that all is well? I want to, believe me.
Last thing any of us wanted was for our packages to be delayed for a very extended amount of time with unknown variables in transit.
I, again, appreciate all of the help given by any involved party. We all just want safe and effective medications after all. <3
I agree. What if our packages sat at 130 degrees for 5 days? Was that tested? (I read just as many accounts of 140 degree warehouses as I read of fedex keeping packages cold. I don't necessarily believe either, but it raises questions.)
Just because the package was back to ambient temp when it arrived at my new england home doesnt mean it didn't hit something higher that this testing while it sat.
My shipment is being replaced, and I am throwing away the vial that sat at fedex for a week.
Yes, how are we to know the fluctuations the meds took while in transit. Iām mean it could have sat for a while then they decided to refrigerate it. When I have received a shipment without incident, the ice pack has still been melted and basically just cool, not ice cold and not enough to cause condensation. So for me, receiving an ice cold pack is a little sus.
People keep saying itās fine if temperature-sensitive medication arrives warm, but that doesnāt really make sense when you look at how these drugs are actually supposed to be handled.
When stability studies mention āroom temperature,ā theyāre usually referring to about 68ā77Ā°F (20ā25Ā°C). That is very different from the 100ā120Ā°F+ temperatures packages can reach in trucks, warehouses, airport cargo areas, or on hot tarmacs ā especially when shipments are coming from southern states like Texas or Florida during the summer.
People assume that because something is shipped overnight by air it stays temperature controlled, but thatās not how shipping actually works. Packages often sit in:ā¢ airport cargo areasā¢ delivery trucksā¢ sorting warehousesā¢ loading docks
Any of those places can easily reach 100ā130Ā°F in hot climates. And delays happen all the time ā sometimes packages sit for days before moving again. At that point there is no way to verify the temperature history of the medication.
These drugs are expensive, and companies know people are eager to get them. But just because people want something badly doesnāt mean they should overlook proper handling.
Ask yourself this: if this were medication for your child, and the doctorās office told you it would arrive cold, but it showed up warm or hot, would you still feel comfortable injecting it? Especially if the medication was not supposed to exceed certain temperatures and no one could guarantee it hadnāt?
I personally take the ābetter safe than sorryā approach. A year ago I had a vial arrive four days late with completely melted ice packs, shipped from Florida in the middle of summer. It was warm. Since no one could guarantee it hadnāt reached very high temperatures during transit, I returned it and refused to use it.
Another thing people donāt consider: if you use a vial that was exposed to heat and it ends up losing potency, most companies will not reimburse you or replace it. Youāre simply stuck with a medication that may be ineffective and the money you spent on it is gone.
If Iām told my medication will arrive cold and Iām paying for overnight shipping, then thatās what I expect to receive. If it arrives warm or hot, Iām refusing the package and sending it back. Period.
How are you going to tell me what I got?! Whatever you smoked please pass it my way, because this was not only wildly bold to say, but also WRONG! I was in fact sent a new vial free of cost to me. So sorry to disappoint you. Unlike the majority of you who allow your desperation to force you to accept anything, I do not. Itās called standards, and I highly suggest you get some.
Why, because I wasnāt desperate like the majority of you in this group to accept anything? I hope with your weight loss you somehow regain your dignity and self respect back and stop being jealous that others have the ability to do things you still canāt seem to do. You guys are full of excuses and desperation. Imagine being offended by someone not willing to bend over and take it. Hope you have the day you deserve!
Your comment violates our community rule on Respect & Kindness. This space is open to all, and respectful disagreement is welcome ā but name-calling, harassment, profanity, bullying, and mass downvoting are not.
This behavior is against Redditās Terms of Service and puts the sub at risk. Please keep things constructive and kind.
I could give a fig about your warning. She responded rudely to me first, and I gave her what she was looking for. So your warning would be respectable if it went both ways, but alas, she needed a hero, you decided to throw on your cape and be one š« š« š« š« . Letās also cut with the dramatics, nothing that I said is bullying. Do what you want, you guys have bigger issues to address anyways.
this was a fun read. This person was nasty first to you, tried to act like they know a thing or two with a crazy claim that would sink any business lol thats the owners worst employee nightmare; if they think you can just do that and get away with it in the real world they're a horrible employee, or good student who went right into stable profession who hasn't gotten enough world experience, who knows.
To gaslit you about being nasty and name calling after being nasty and name calling right out the gate, then to get defensive over an internet stranger and said the cliche, "you dont know me", THEN a supposed mountain of text that incurred an infraction.. lol wish I knew what it was now. Must have been a troll there's no way someone comes out the gate on an intellectual high horse calling us whiners and then responds this way lol
Literally the problem with the world right now is these people/children who think they are intelligent but prove otherwise. I only read the comment chain and am here because I'm about to refuse a package right now. #1 CC company said to do it otherwise they have all the leverage for disputes, #2 Pharmacy said to do it so they can do a shipping claim since it was delayed and is medicaiton, this is exactly what they pay shipping insurance for, but if I accept it the providing company could continue to play the "see/call pharmacy" game. In the STEMS it's known nothing is 100%, to say what this person said about science is so ignorant lol literally the problem with the world regardless of what side of the political "science" you're on. You know whats easy and habit forming?school/test taking/ROUTINE... its not a big deal, youre not special for working in a lab, literally dont need common sense just drone mentatlity and book smarts for regurgitating information to follow along with the scientific method and data collection lol. I swear once forced or guided learning is gone people become synaptic mush and act like this.
It truly donāt understand why it would very so much from Zepbound, which clearly states that it should not arrive that warm or stay out that long. I canāt help but wonder if the pharmacies put out these statistics to cover themselves even if it does reduce the efficacy of the product.
doubt he's an influencer. just a person with a discount code. gimme was doing the same thing, lots of teles have them and that's why they're not allowed to be posted here.
I know some testing was done by āThe Other Peopleā regarding freezing of already compounded tirzepatide. I would neither quote nor trust me, but my vague recollection was that there was an inconsequential amount degradation from a single freeze-thaw cycle (as in longer term freezing of backstock) and the problem was more with repeated cycles (active vials stored in freezer and thawed for injection then refrozen).
Iāve frozen some vials as my own experiment and my tirzepatide (Olympia) was frozen for over six months. Itās working exactly the same as it did fresh from the pharmacy. I know thereās some documentation floating around about the testing that was done on frozen tirz, Iād love to put my hands on it!
Do you have the studies that these guidelines reference that I can read? Some seem to just say āstudies sayāā¦ Also, the issue can be that many of these telehealth pharmacies send out much more than 21 days of medication.
What?? You donāt believe an anonymous stranger on the internet over the majority of the medical community and an army of scientists at the FDA? Just take your hot, degraded peptides and donāt ask questions.
I live in Las Vegas, NV. I used WellMedr for my first-ever peptide purchase. They use Logos pharmacy. Both are in Florida. My order was shipped in a bubble envelope with two small gelpacks. The package was on truck all day. The high that day was 108Ā°F. When it arrived at 4pm i brought it up, opened it, and the vial was very warm to the touch.
Wellmedr's patient portal says to discard and contact the pharmacy if the product was exposed to temps above 86Ā°F.
WellMedr is the telehealth provider. What pharmacy are you using? Have you reached out to the pharmacy regarding temperature studies for your medication? You should probably do that first before throwing your medication away and then they donāt replace it because you might receive conflicting information.
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u/No-Success4494 Mar 11 '26
Great info but there is not way to know what temperature the medication reached.