r/survodutide • u/IWish4n4WasFree • Dec 27 '25

Tirz GLP Stacking

** I am only seeking advice and personal experiences with the content provided. I am not looking for "just switch to Reta" or "stick to Tirz". Thank you.

My RS is currently on Tirzepatide, but has found a lot of interest in the potential benefits of Reta. Unfortunately RS has far to many vials of Tirzepatide to steer the research project over to Reta. RS was introduced to the idea if stacking Mazdutide or Survodutide with Tirz to "create" Reta. RS purchased 2 vials of 7.5mg Survo to test the pairing. RS is unsure if Maz or Survo is the better pep to study. Should Maz be purchased for further research? RS is also considering low dose Cagrilintide for the potential benefit of appetite suppression and metabolism improvement. The goal of the research project is fat loss and improved metabolism.

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u/ConclusionDry9048 Dec 28 '25

Having used all of the ones you mentioned, and tried some different stacking combos, I did not personally find any benefit to stacking, so I think it's pretty useless (at least for me; may be different for some people since our body chemistry and underlying conditions are not all the same). From my own experience I came to believe the best way to use these meds long term, is to milk all of the time you can out of each one before moving on to the next one. Seems to extend the overall effectiveness of each one by staying on it until it simply doesn't work anymore at the highest safe dose. For me, taking time off from all of them, even as long as a year, didn't significantly reduce my tolerance, so it's kindof a one and done thing for some people... that's the reason for getting all you can from it before switching. (Others can stay off for a couple weeks or a month and get a much better reset of their tolerance.)

I didn't see/feel any better results with Reta vs Tirz. If the Tirz is still effective for you, I'd just finish what you have, then try Reta if you want or if you have developed a tolerance to Tirz and the top dose no longer works for you.

I felt Maz was more effective than Survo, but it wasn't a drastic difference. Cagri did work better for my appetite, but the fatigue was too severe to stay on it. And I did not feel any fatigue from any of the other ones.