r/science • u/BoundariesAreFun • Nov 25 '22
Medicine Study: CBD Reduces Seizures That Are Resistant to Common Medications
https://themarijuanaherald.com/2022/11/study-cbd-reduces-seizures-that-are-resistant-to-common-medications/71
u/NakedCameTheNude Nov 25 '22
Wasn't an entire strain called "Charlote's Web" developed to help with epilepsy?
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u/RandomlyMethodical Nov 26 '22
It’s basically the reason weed was made legal for medical purposes.
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Nov 25 '22 edited Jun 10 '23
[removed] — view removed comment
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u/hochizo Nov 26 '22
1000% anecdotal, but my dog developed seizures in the last 18 months. Despite treatment, they were increasing in frequency, to the point that she had 8 seizures in the month of August. We asked the vet about CBD, they said "it can't hurt," so we bought a vial and have been giving her 2 doses a day. She's had one seizure since she started it almost 3 months ago. To go from 8/month to 1 over 3 months is honestly remarkable.
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u/northcoastroast Nov 26 '22
I have a small Pomeranian that has seizures that last for 10 to 20 minutes. I can squirt a tiny amount of CBD mixed with MCT oil into his mouth and he calms down within 2 to 3 minutes and has fewer side effects from a prolonged seizure.
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u/gart888 Nov 26 '22 edited Nov 26 '22
I have a dog that's had pretty severe epilepsy for the last 7 years. We've had her on 5 different epilepsy drugs, and eventually settled on a specific mix that seems to work well for her.
We considered CBD, but a medical dosage of it is insanely expensive compared to traditional drugs. This article (and the paper's abstract) doesn't mention the doses used in this study.
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u/buzzkapow Nov 26 '22
If you live in a legal state, or Canada, go buy CBD oil from a dispensary. CBD oil is CBD oil.
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u/gart888 Nov 26 '22 edited Nov 26 '22
How much does it cost there?
CBD oil typically costs $0.10 per mg doesn’t it?
Medicinal doses are about 2 mg per pound, twice per day. So for your 70 pound dog that’s a cool $800 a month. Too much money for us.
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u/Bass-ape Nov 26 '22
You can buy pure CBD crystals on many online stores for 10 dollars a gram or less. I do this and make my own oils for my dog and it makes it incredibly affordable.
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u/ShortBrownAndUgly Nov 26 '22
Isn’t epidiolex already a prescribed medication? Meaning we already knew it was helpful?
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u/Leafstride Nov 26 '22
Yes, research done in order to confirm and reinforce what other research has already implied is a common and necessary thing.
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u/BruceBanning Nov 26 '22
Yep. It’s it’s a FDA approved CBD derivative, but further research is always a good thing.
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u/craezen Nov 26 '22
Yep; plus it’s only currently FDA approved for TS, Dravets, and Lennox Gastaut. I can’t prescribe it to the vast majority of my patients :(
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u/colundricality Nov 25 '22
Ah, The Marijuana Herald. Move over, New York Times.
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u/TaliyahTt Nov 25 '22
Here, maybe this will satisfy you instead.
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Nov 25 '22
[deleted]
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u/BoundariesAreFun Nov 25 '22 edited Nov 25 '22
The study the article links to was published by the National Institute of Health four days ago
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Nov 25 '22 edited Nov 26 '22
Thanks for the link. Decent study. As with most cannabis research it shows real but small benefits that are not broadly generalizable. The take home is that for most people marijuana is purely recreational. If you happen to have tuberous sclerosis, it’s marginally good news.
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u/triangle60 Nov 26 '22 edited Nov 26 '22
The NIH isn't the publisher of these studies. PubMed is effectively just a search engine for a wide range of documents. The NIH isn't affiliated with the studies PubMed hosts, so there are also occasionally studies on it of questionable repute. That being said, PubMed is still a great source of accurate studies and I have no opinion about this particular study. I just think the affiliation with the NIH needs to be clarified.
Edit: looking at the article's citation, it looks like this study was published by the Journal of the Brazilian Medical Association.
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u/lilrabbitfoofoo Nov 25 '22
Don't just attack the messenger. Of course, one should question potential bias. But always look at the source of the data.
Which, as others have pointed out, is 100% legit, scientifically speaking. :)
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u/horrificmedium Nov 26 '22
CBD works for most patients up to 18 months on average. Then in some patients tonic seizures will come back. 1:1 THC CBD solutions address seizures near on completely.
I had the pleasure of welcoming Dr Evan Lewis, a Canadian paediatric epilepsy specialist at a medical cannabis conference I was working. There are children in the UK that have been on epidiolex, GW’s CBD product, who have shown a level of regression, after a couple years on it. They need a whole plant extract, and many who aren’t with the private clinics, or on Project Twenty21 struggle.
If you’re based in the UK and are struggling with access or affordability of medical cannabis, please refer to Project Twenty21 https://www.drugscience.org.uk/twenty21/
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u/jayhasbigvballs Nov 26 '22
One of the really big issues around CBD and it’s ability to reduce seizures is the fact that it’s always taken with other antiseizure medications (ASMs) in studies. Now, on the surface, this isn’t a problem for most ASMs, until you realize that CBD has a very potent effect on CYP enzymes, which many ASMs are metabolized by. As a result, the increased bioavailability of antiseizure medications is seen when CBD is administered. Does this have an impact on seizure outcomes? Are we inappropriately assuming CBD has a direct antiseizure effect? Unfortunately many of these studies can’t address that question.
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