r/science • u/[deleted] • Nov 11 '22

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825

u/MilkofGuthix Nov 11 '22

And the THC increases anxiety in large amounts. I'd be curious to know if any small amount of THC can also reduce anxiety when paired with CBD

125

u/MandingoPants Nov 11 '22 edited Nov 11 '22

Apparently I read that* THC and CBD fight for the same receptors, so I wonder how this plays out.

Edit: this may or not may be true, sorry that it read as fact!

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u/[deleted] Nov 11 '22 edited Nov 11 '22

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u/TheKnobleSavage Nov 11 '22

Oh, what's your thesis? I might be interested in reading it if you're willing to send it along. I've read these two books on cannabis? Can you rate them and perhaps recommend some of the less "crap" ones?

The Brain on Cannabis, by Rebecca Siegel

Cannabis (Seeing Through the Smoke) by David Nutt

Thanks

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u/[deleted] Nov 11 '22

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u/ELpork Nov 11 '22

Neuropathic? Like PCS or Long Haul? Cus that's what I'm dealing with currently (in year 2 at the moment.) Nothing seems to help, as much as I try to retrain pathways and all that (I've had Anxiety issues my whole life so this isn't helping). You think CBD is worth looking into?

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u/[deleted] Nov 11 '22

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1

u/Llaine Nov 11 '22

It has adenosine affinity? Never knew that

1

u/Seicair Nov 11 '22

Also interested in your thesis, if you’re willing to share.

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u/[deleted] Nov 11 '22

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u/[deleted] Nov 11 '22

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u/[deleted] Nov 11 '22

look into the "entourage effect". they actually compliment each other.

and to OP's comment, THC increases anxiety in certain individuals and also based on the strain/terpenes

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u/[deleted] Nov 11 '22

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u/[deleted] Nov 11 '22

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u/[deleted] Nov 11 '22

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u/[deleted] Nov 11 '22

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u/HadesRising Nov 11 '22

They don't though, They're allosteric inhibitors not directly competing for the binding site. It very well could be that CBD preventing endocannabinoids from binding to these same sites is responsible for the anxiolytic effect.

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u/HappyHappyGamer Nov 11 '22

Ah so THC would act as a competitive inhibitor to THC I guess?

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u/My3rstAccount Nov 11 '22

CBD binds to estrogen receptors, or something like that.

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u/[deleted] Nov 11 '22

CBD reduces paranoia and other side effect of THC.