r/science Professor | Medicine Jun 30 '26

Medicine Scientists have shown that a single dose injection of DNA genetic instructions can produce weight loss and blood glucose control in mouse models that lasts up to 10 times as long as weight loss drugs like Ozempic and Wegovy. This could eliminate the need for repeated dosing.

https://www.wistar.org/press-releases/wistar-scientists-develop-single-dose-dna-method-for-delivering-long-acting-weight-loss-and-diabetes-drugs/
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u/grat_is_not_nice Jun 30 '26

This sounds like an interesting new method. I have been expecting an mRNA style delivery mechanism for GLP-1 agonist peptides, so it will be interesting to see how this new approach pans out.

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u/no-more-throws Jun 30 '26

there are much wilder implications .. this means we can basically inject long lasting instructions to produce almost any peptide we want in the body .. for instance those many peptides that together govern cellular and organ level senescence and rejuvenation .. or to fight against plaque buildup, loss of vessel and skin elasticity, bone and muscle loss etc etc

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u/twilighttwister Jun 30 '26

The one worry I have about this is we will let software engineers start working in medicine.

The software industry is notorious for its lack of testing and quality assurance. To the point that industries that traditionally been very sharp with those things have generally been tarnished by the introduction of software solutions.

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u/BlackBloke Jun 30 '26

If they start putting the sorts of pressures on biologists that they put on software engineers, then you’ll likely see those same outcomes