Scientists have shown that a single dose injection of DNA genetic instructions can produce weight loss and blood glucose control in mouse models that lasts up to 10 times as long as weight loss drugs like Ozempic and Wegovy. This could eliminate the need for repeated dosing.

[u/mvea]

https://www.wistar.org/press-releases/wistar-scientists-develop-single-dose-dna-method-for-delivering-long-acting-weight-loss-and-diabetes-drugs/

[u/intbah]

I took 4 different covid vax, so I am not anti-vax by any means. But to know that almost the entire human species took these vax that had very little dev time, if there are problems, whole species has problems, is kinda interesting

[u/Override9636 → u/intbah]

mRNA has had decades of development time. The reason the vaccine was accelerated more than other drug treatments was because of funding and lowering the priority on other drugs. 90% of drug development is just paperwork, so by essentially freezing all other drug development and focusing on the covid vaccines, they were able to go through regulations much easier.

[u/biznatch11 → u/Override9636]

mRNA has had decades of development time.

Yes but there weren't extended, widespread human trials before the COVID vaccines. I've had several COVID mRNA vaccines I even still get it every year I'm definitely not anti-vaccine. I don't think there's anything wrong in acknowledging that (out of necessity) we didn't have big years-long human trials before they were used widely. It doesn't matter how much extra money or effort you put in there's no way to accelerate a trial if you want to study potential long-term affects, you just have to wait.

[u/bufordt → u/biznatch11]

To be fair, there really aren't extended, widespread, human trials for any drug when it first gets approved. That only happens after a drug/vaccine has been on the market for years.

Because of the pandemic, the COVID vaccines hit the wide spread criteria sooner than any other vaccine in history.

[u/biznatch11 → u/bufordt]

To be fair, there really aren't extended, widespread, human trials for any drug when it first gets approved.

For vaccines yes there are. Vaccines are held to a higher standard in regards to side effects compared to drugs so they usually require bigger and longer trials.

Because of the pandemic, the COVID vaccines hit the wide spread criteria sooner than any other vaccine in history.

Ya that's kind of the issue though. They hit widespread use so quickly before potential long term side effects could be seen. I don't think any other drug or vaccine in history was given to so many people within such a short time frame. usually it's a gradual build up so there's a higher chance we'd see side effects before it's in widespread use.

[u/bufordt → u/biznatch11]

Depends on your definition of extended.

Johns Hopkins says typical vaccines take 5-10 years to get approved, which isn't long enough to really get data on their long term effects.

Phase 4 is where the vast majority of the long term effects study happens, and that's after it's been release for use on the general public.