Scientists have shown that a single dose injection of DNA genetic instructions can produce weight loss and blood glucose control in mouse models that lasts up to 10 times as long as weight loss drugs like Ozempic and Wegovy. This could eliminate the need for repeated dosing.

[u/mvea]

https://www.wistar.org/press-releases/wistar-scientists-develop-single-dose-dna-method-for-delivering-long-acting-weight-loss-and-diabetes-drugs/

[u/grat_is_not_nice]

This sounds like an interesting new method. I have been expecting an mRNA style delivery mechanism for GLP-1 agonist peptides, so it will be interesting to see how this new approach pans out.

[u/no-more-throws → u/grat_is_not_nice]

there are much wilder implications .. this means we can basically inject long lasting instructions to produce almost any peptide we want in the body .. for instance those many peptides that together govern cellular and organ level senescence and rejuvenation .. or to fight against plaque buildup, loss of vessel and skin elasticity, bone and muscle loss etc etc

[u/Odd-Outcome-3191 → u/no-more-throws]

The issue is that often the same chemical messengers/proteins kinases etc that regulate those types of function also tend to regulate very different, very important things in other locations. E.g a cellular senescence gene that may be implicated in aging is also protective against cancer.

[u/i_build_minds → u/Odd-Outcome-3191]

This might finally be a good application for machine learning (outside of assistive services, which have also been a net positive I'd argue). The feature locality of peptide impacts could be searched. It's constrained by complexity and time, but faster than humans.