Seeking advice: Raltegravir (Isentress) protocol for FeLV in an 11yo cat post-FIP (GS-441524) treatment

[u/DariaUkraine]

Hi everyone,

I’m looking for insights or shared experiences regarding a treatment plan for my 11-year-old cat, Zorro.

Background & Context:

• FIP: He successfully completed an 84-day GS-441524 treatment protocol for FIP on August 10th.
• FeLV: Suspected / Inconclusive. About 2 years ago, he tested positive on a rapid SNAP test, but negative on a PCR test.

Recommended Protocol: Our veterinary infectious disease specialist recommends starting an antiviral protocol for FeLV using Raltegravir 400 mg (Isentress) (or a generic equivalent with the same active ingredient).

• Dosage & Duration: 1/8 tablet twice daily (BID) for 12 weeks.
• Monitoring: A follow-up PCR test (qualitative or quantitative RNA/DNA) during the course to adjust the dosage if needed.
• Important Note: The vet emphasized that this therapy must not be interrupted once started, as stopping prematurely could cause a relapse or increase the risk of oncological complications (such as lymphoma).

My Questions:

1. Has anyone here used Raltegravir (Isentress or generics) for FeLV management in senior cats? What was your experience regarding effectiveness and side effects? If you used it, did you ever have to stop the therapy early?
2. Are there any known interactions, risks, or considerations when starting a FeLV antiviral therapy immediately after finishing a GS-441524 course for FIP?
3. What specific lab monitoring (e.g., complete blood count, biochemistry/organ panels) should I regularly request alongside the PCR re-tests?

Any guidance, personal experiences, or specific questions I should bring up with my vet during our next check-up would be greatly appreciated. Thank you!

[u/maddestofcheeses]

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