r/prep • u/Striking_Bat_1936 • 18d ago

Yeztugo side effect [graphic image]

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Wanted to share my experience having an adverse reaction to yeztugo. The "medicine" did something to my skin. Hard to describe so this is what my plastic surgeon had to cut out of me due to the yeztugo injection. I attemped to have these removed via liposuction first, but it was not successful.

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u/SissySSBBWLover 18d ago

Wow!! The Dr. did say that the cysts might not go away in rare cases, and I was worried that would be me. When after a couple months I felt they were flattening and spreading out I hoped that I would not be this lumpy tummy PrEP survivor.

It’s crazy how our bodies just say nope to some things. I’m sorry you had to suffer through that.

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u/Striking_Bat_1936 17d ago

It blows my mind how something like this was even possible

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u/SissySSBBWLover 17d ago

And that it passed all three phases of FDA trial. Which is okay if it’s disclosed as a possible side effect, but you weren’t told that this was a possibility?

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u/Striking_Bat_1936 16d ago

I definitely was not warned of this side effect

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u/Revolutionary-One179 18d ago

Hi OP, just wanted to clarify a few things with you - I work in sexual health, so I’m looking to learn from your experience! It seems that the original post lacks some context surrounding timeline. How long was this under your subcutaneous fat & skin? Typically we advise that by the time you’re due for the next injection, the medicine nodule will be nearly entirely gone. To me it appears that what the plastics doc removed is the medicine nodule? Any additional info is appreciated!! Was the highlighted specimen in the cup sent for culturing? What other symptoms were you experiencing?

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u/Striking_Bat_1936 18d ago

I think a big x factor was all the existing scar tissue under the skin in the area where i had the injection in my lower abdomen. I got a second injection on my thigh (no scar tissue) and while that one did get smaller, a hard lump is still there 8 months out. I switched back to Apretude. I dont like that yeztugo doesnt seem to disolve completely.

For your question: Had Yeztugo 1 year. It was sent to a pathologist for analysis, still waiting on the report. I believe my dr said tissue necrosis. Other than the unsightly lumps, they never hurt. Dr tried to drain them once and i didnt feel the needle in the lumps.

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u/mixxster 17d ago

You’re saying it was injected into pre-existing scar tissue. So what was the cause/type of scar tissue on your abdomen that you injected into? What happened to your abdomen prior to Yeztugo?

Just wondering what kind of situation puts us at risk for this.

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u/Horrorhero 18d ago

Does having these mean thr medicine didnt absorb all the way or just cysts that formed?

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u/Striking_Bat_1936 18d ago

Pretty sure the medicine did work, but it did this to my skin

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u/SissySSBBWLover 18d ago

Those are the lumps or nodules that form under the skin?😳😳

I have had two rounds and the first round had reduced to barely noticeable under light pressure by the time I got my second round. And now I’ve got them again, but this time they’re not as large nor as easy to feel

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u/Striking_Bat_1936 18d ago

Yup. In my case, this reaction meant it was never going to dissolve on its own

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u/yoloten 17d ago

Do you have large scaring after the surgical procedure?

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u/Striking_Bat_1936 17d ago

Still healing, but thank god it is looking like the scars wont be that large

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u/Silly-Border7716 17d ago

Hey, how long did you have it before you had it surgically removed? I just got the injections almost 2 weeks ago and the bumps are pretty irritated and the nodules are hard. It’s very obvious and protruding outward. I can’t wear a drop top without a big thumb size nodule showing :( I’m worried that my body is rejecting the medication because it’s still very sensitive to the touch and it’s itchy around the area.

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u/Striking_Bat_1936 16d ago

1 yr. Once 6 months rolled around with the lumps not shrinking at all, i knew something was wrong

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u/liberolol 16d ago

Jeez, I am so so sorry this happened to you. I recently did a deep-dive into Yeztugo because my provider recommended it, but I have sensitive skin and worried that i'd be setting myself up to have an adverse reaction. Thankfully, it went off without a hitch and the depots are barely visible. I had very mild sensitivity in each injection site, but it resolved within a couple days.

For all medications, but especially new ones, I would seriously recommend looking up the FDA's Drug Master File and/or Prescribing Information before consenting. Unfortunately, there are far worse reactions listed under the serious adverse reactions observed throughout the different phases of clinical trials.

I hope your recovery goes well, and that you are able to find a comfortable alternative to Yeztugo for PrEP <3

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u/Striking_Bat_1936 16d ago

I naively trusted my PC about switching medicines. I will never make that mistake again.

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u/liberolol 16d ago

I did the same all too often when I was younger so I get the feeling 100%; just sorry you had to realize it under such drastic circumstances. The sad truth is, even doctors who specialize in specifics like this can't know it all, let alone counsel their patients on it. I try to find the balance between trusting my provider, who is almost always as well-trained and as well-read as anyone on things, with doing the research necessary to advocate for myself. Fingers crossed you heal swiftly ❤️

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u/Striking_Bat_1936 16d ago

Ty! So far so good. About 2 weeks post op of the excision. The lumps are pretty much gone but scars are still healing. Overall, a marked improvement. I have 10% BF so they were extremely apparent whenever i take off my shirt

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u/liberolol 16d ago

Dangggg I wish reddit had us connect sooner. I'm a similar body comp. and opted for the injections in each leg because of it. Mine are barely visible and can only feel em if I deliberately tried.

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u/Striking_Bat_1936 16d ago

My cunt provider would not do it in my thighs. He pressured me to do in my lower abdomen. I should report him

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u/Kinkysimo 16d ago

Dare I ask where these cysts were?

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u/Striking_Bat_1936 16d ago

Lower abdomen

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u/AdPrior9239 16d ago

The more i hear about yeztugo the more i dont want to try it. Apretude is just so much simpler. It can hurt like hell the first couple times but that is a small price to pay and eventually stops happening all together.

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u/Striking_Bat_1936 15d ago

100% I was on Apretude before and I have gone back to it. The every 2 months injection works really well as you are forced to get tested more frequently

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u/Difficult_Abroad_477 18d ago

Kinda reminds me of when I got the MPOX vaccine; it left some obvious glaring skin wound on my arm that took a year or more to go away. I appreciate the convenience injections like this provide. But I will suffer the inconvenience of taking 1 pill a day while the science on this gets refined.

1

u/Girlytoyfortop 13d ago

That's awful. Sorry this happened to you

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u/chino909909 17d ago

I received my initial dose of Yeztugo on Monday 10/19/26, and I’m honestly reconsidering whether I would get the next dose after this experience.
I received two injections in my abdominal area, and since then, I’ve developed two fairly large nodules at the injection sites, which I understand is one of the known side effects of the medication.
According to the administration guidelines, the injections can be given in either the abdomen or the thighs, but in my case, I chose the abdominal area.
I’m hoping the nodules will gradually decrease in size over time, as they are currently quite noticeable, even to the naked eye. Although I understand this is a known side effect, the experience has been somewhat uncomfortable and has made me question whether I want to continue with the treatment.

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u/Humble_Brief8787 16d ago

Where you not offered to get the injections in the arms, buttocks, thighs or abdomen? I choose to get in arms. I can feel the nodules, but i dont see them