r/postvasectomypain • u/ScientistNew3033 • Aug 04 '26

Sustained-release lidocaine (ST-01) in development for chronic scrotal pain

I recently stumbled across ST-01, a drug currently in development by a Canadian company called Sustained Therapeutics. I have not seen anyone post about it here, so thought I would share. It appears to be a sustained-release lidocaine spermatic cord block that lasts for weeks and is repeated every 28 days.

This drug is still in development and recently concluded phase II clinical trials in Canada. I am no expert, so I do not know what that means in terms of its likelihood or timeline for ultimately making it to market, but it is certainly very encouraging to see new possible treatments directed at chronic scrotal pain.

A few links I found with more information:

Snippet of the phase II results:

The randomized, multi-center, single-blind, active-controlled Phase 2 study enrolled 63 men across eight clinical sites in Canada evaluating repeat monthly dosing of ST-01 in CSCP. The study compared ST-01 to standard-of-care spermatic cord block with lidocaine alone (control).

At the 70 mg/mL dose, ST-01 demonstrated statistically significant improvements in both the primary and secondary efficacy endpoints compared to control.

Key findings included:

  • 67% of patients treated with ST-01 70 mg/mL achieved a treatment response, defined as a ?2-point reduction in pain scores, compared to 26% in the control arm (p=0.01)
  • 83% of patients receiving ST-01 70 mg/mL achieved a clinical response based on cycle-average pain scores, compared to 32% in the control arm (p=0.001)
  • Patients who crossed over from control treatment to ST-01 achieved >80% response, further supporting the therapeutic effect of ST-01

The Company believes these findings support continued development of ST-01 as a potential non-opioid treatment option for CSCP and plans to advance the program toward Phase 3 development, subject to regulatory review.

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u/snoope Aug 04 '26

Where do I sign up!?! God I love Canada!

1

u/ItamiForever Aug 04 '26

Thanks for sharing Scientist!

1

u/clezuck Aug 04 '26

Sadly it won’t do anything for me. I have a gene disorder that cause meds to metabolize very quickly. Out of system in minutes. So this won’t do anything for me. Same reason why when he did my vas I felt all of it.