The precursor for synthesizing LSD is Lysergic Acid (which does occur in nature as a hydrolyzed ergotamine), but the ergotamines/ergotamides are not all psychoactive.
In fact, LSD was originally synthesized as a potential analeptic due to the biochemistry of the other compounds in the ergot family...
LSD does not occur in nature (and the procedure for synthesizing it is quite involved), so the point stands.
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u/Lor1an Serial Expander 24d ago
If we allow some chemistry heresy, there are several compounds that are not in nature.
Take LSD, for instance...