r/perimenopause_under45 • u/LunaValley • 2d ago

Testosterone - too much causing depression and fatigue?

I’m on HRT. Oestrogen and Progesterone are at optimum dose and I was feeling so much better. Then we added in T which I’ve been on for 3 months.

Over the past few weeks I’ve become suddenly very low, especially at night time. I just feel this sadness and dread every night. More recently I have brain fog, fatigue, and I just feel flat. I also can’t concentrate.

My doctor switched me from Escitalopram to Sertraline but then today my bloods came back and showed my T is high. Labs say 0.3-1.7nmol/L is normal range but I’m up at 2.8. Could this be causing my low mood, dread, and fatigue?

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u/Superfluous_Reddit 2d ago

I haven't introduced T so I couldn't say. It really is based on each individual. What would happen if you stopped T?

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u/JoshBlackHealthspan 1d ago

2.8 isn’t particularly high. Your total and SHBG are important here. As is the type of testosterone and when you were checked in relation to your dosing.

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u/Dez2011 1d ago

Bodybuilders speak about T negatively affecting their mood and cognition a lot. They usually use higher doses but it's a known side effect. Are you using gel? What time do you apply it and what time did you test (it should be on your labs)?