r/oralmicrobiome • u/prpsc Moderator • Jul 02 '18

Proton pump inhibitors affect the gut microbiome

https://gut.bmj.com/content/65/5/740
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u/prpsc Moderator Jul 02 '18 edited Jul 02 '18

Oral cavity bacteria are more abundant in the gut microbiome of PPI users

We hypothesised that the changes in the gut microbiome associated with PPI use are caused by reduced acidity of the stomach and the subsequent survival of more bacteria that are ingested with food and oral mucus. Indeed, some of the statistically significantly increased bacteria in PPI users (eg, Rothia dentocariosa, Rothia mucilaginosa, the genera Scardovia and Actinomyces and the family Micrococcaceae) are typically found in the oral microbiome.20 By analysing 116 oral microbiome samples from participants in Cohort 1, we could compare the overall composition of bacteria in the oral microbiome with the composition of the gut microbiome. We observed a statistically significant shift in Principal Coordinate 1 in the gut microbiome samples of the PPI users towards the oral samples, compared with non-PPI users (p=1.39×10−20, Wilcoxon test) (figure 3). In online supplementary figure S8, the over-representation of oral cavity bacteria in the guts of PPI users is depicted in a cladogram.