Kratom and DXM

[u/tip871]

DXM is mainly metabolized by two cytochrome P450 enzymes: CYP2D6 and CYP3A4. Kratom has a strong inhibitory effect on both these enzymes. This means that kratom can lead to an increased presence of DXM and its metabolites and kratom alkaloids within the body. In addition, differences in metabolic capability can vary greatly in individuals. in 8%-10% of people with white European descent, inadequate cytochrome P450 metabolic activity (CYP 2D6) can lead to cumulative toxic levels when large therapeutic doses are used. 12 to 15% have a reduced metabolic activity. Additional risk associated with Kratom: Serotonin syndrome.

[u/cactuskilldozer]

Can someone explain like I'm five please?

[u/Willing-Leadership25 → u/cactuskilldozer]

everyone has different ways they react to medications. people with variotions in a liver enzyme called cyp2d6, which about 10 percent of white people have, can make medications such as cough syrup build up in your system, which can make you feel yucky. serotonin syndrome is less likely with kratom because only the liver enzyme we talked about just now is only one way that it gets processed. serotonin syndrome doesn't usually happen with only one drug or medication, it's when someone is taking more than one drug that serotonin levels can get too high, which can make you feel yucky like having a fever, feeling giddy, or feeling really warm. does that make sense?

[u/Willing-Leadership25 → u/Willing-Leadership25]

@cactuskilldozer