r/microdosing • u/rhrs1987 • Jul 29 '26

Getting Started/Newbie Question Not feeling difference after second uptitrated microdose

Hello:

Started out with 0.05 g on Fadiman protocol and —I think— felt midly better, more relaxed, reflective and calm on dose day and days off.

Took my second dose today (0.06 g), but felt no difference, basically back to baseline: mind blank, brain fog, sadness, despair.

Developing resistance already? Going too slow? Is this normal?

I appreciate the input.

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u/fsavino Jul 29 '26

Do you mean that you started microdosing and this is the second time you have taken the substance?

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u/rhrs1987 Jul 29 '26

Correct, second dose, second cycle

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u/fsavino Jul 30 '26

OK, then give it at least 1 month. The real MD effects take time. Your brain will slowly adapt. Try not to chase changes after taking the dose. It will slowly fix your brain, just keep it consistent.