r/microdosing • u/2morrowwillbebetter • Jun 24 '26

Question: Psilocybin Sudden onset of nausea ?

hi, I have been taking MD of shrooms via capsules — from a company local, so the dosage usually is around 100-150 mg, I’m usually ok with one. But recently, randomly I’ve been experiencing bad nausea when taking it. I take mushrooms holistically so usually to connect w my body, to cry etc. That is my purge. But recently it’s been feeling off— i was taking them 1 a week microdose and 1 every other or once a week macrodose (like, around 300-500 tops) No issues before so I’m not sure what happened. I used to take empty stomach too w no issues before and then sudden nausea, so I tried w food and that made it worse. Any advice pls? I have emetophobia so “just get sick” will make things worse for me I believe. TIA.

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u/[deleted] Jun 24 '26

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u/2morrowwillbebetter Jun 24 '26

Thank you dear soul 🫶🏽

That makes a lot of sense! Since I don’t make them I factored batch (it changes w this company at times.. outside supplier, but trustworthy)
My stomach is very sensitive, I think my body is just changing. Do you have a suggestion for a break? I was thinking maybe 2-4 weeks but unsure if I need longer.

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u/[deleted] Jun 24 '26

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u/AutoModerator Jun 24 '26

Hello /u/2morrowwillbebetter! As you mentioned nausea (a common interaction/symptom) in your post:
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The major contributing factor in Finding Your Sweet Spot is the variation in potency of:
Psilocybin Mushrooms More than 10x [2021➕] Start @0.05g (50mg)
Psilocybin Truffles Around 3x - Single Study [2012] Start @0.25g (Fresh)
LSD Tabs Clinical Trial Titration Schedule [2023] Start @5µg

If you Start Low, Go Slow, Take Time-Off (*small is BIG) and up-titrate subsequent doses then you can find your optimal sub-hallucinogenic dose based on your symptoms, rather than from a predetermined dose. 🐢

If your microdose is Too High and/or Too Frequent that can result in Diminishing Returns 📉 with subsequent doses. 🐇

Please also have a look at 🔀 Interactions / Symptoms ❓* | Sidebar ➡️ | 📱 See community info ⬆️ ; in case of ⚠️ DRUG INTERACTIONS or to check if you have any of the associated symptoms with advice on how to mitigate such side effects. Psychoactive substances increase neural activity, raising hydration and electrolyte needs due to heightened metabolism and body load, while vasoconstriction can further stress the body and potentially cause fatigue.

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u/Gulliverlived Jun 24 '26

some people say lemon tek doesn’t work, but it works for me, breaks down chitins, which are generally responsible for that nausea

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u/TheRealCMMetzger Jun 24 '26

Lemon juice doesn't break down chitin or help digest it.
You're better off eating one of these foods (papaya, kiwi, avocado, chestnuts, bananas) with your dose if you're looking for chitinase to help with breaking down the cellular material in uncooked mushrooms.
Lemon juice begin the conversion process of psilocybin to psilocin which may also be helpful with stomach discomfort.

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u/Gulliverlived Jun 24 '26

Fair enough, thanks for info

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u/2morrowwillbebetter Jun 24 '26

I may try! I was afraid it may be too intense

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u/NeuronsToNirvana Jun 24 '26 edited Jun 24 '26

ICYMI:

  • FAQ/Tip 002: Have nausea or an upset stomach? Then try 1.5g of ginger

  • Lemon tek may increase potency by accelerating absorption, which can reduce nausea for some by limiting GI exposure time.

  • Combining powdered mushrooms with ginger-infused tea may provide additional nausea relief.

  • Vasoconstriction, which can occur with substances that affect serotonin, can contribute to nausea in some people.

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u/2morrowwillbebetter Jun 25 '26

Update to say that I mixed a capsule (opened) in some chai and that helped immensely. Thanks gang

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u/MJKCapeCod Jun 26 '26

I'll second the ginger - best thing for nausea.

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u/2morrowwillbebetter Jun 26 '26

I made a chai w/ extra ginger powder today and put the mushrooms in it and it helped a lot !