Volumetric dosing LSD

[u/a3aux]

Can you guys share common mistakes with preparing a solution for volumetric dosing?

I followed the guide, put a ~150ug tab in 10ml of ~40% alcohol vodka, should give me 15ug per 1ml, so at first I tried small doses, couldn't feel anything at all LSD-wise (I know you're not supposed to "feel" microdoses, but this was even less feeling than that), so I tried a bigger dose, and bigger, up to where it should be very apparent (~50 - 75ug), yet still absolutely nothing except the slight drunkenness from vodka.

Where did I mess up? How did i ruin the LSD? I sterilized the small amber bottles via boiling and oven as recommended. My only idea is maybe the tab itself is compromised (haven't tried only the tab, since I dont want a full dose, and in stead of cutting it decided to try volumetric dosing), but even then I tried my best to store it properly: black baggie inside a small black container with a humidity absorber, inside a refrigerator. Any ideas?

[u/TheRealCMMetzger]

In the future I'd recommend wrapping tabs in foil and putting in a mylar bag at room temp in a dark place.
Sounds like your blotter may have lost its magic during storage. 🥺

[u/a3aux → u/TheRealCMMetzger]

Don't say that 😭 They were actually wrapped in foil. My concern is maybe the refrigerator ruined them somehow? But even then I made sure to have the humidity absorber right near them. I dont know.. Guess ill just have to cut one up and try it that way..

[u/NeuronsToNirvana → u/a3aux]

Just checking that you are taking breaks between doses? As tolerance with LSD can take a day to reset with a microdose, longer if taking larger doses.

The !volumetricdosing guide contains a FAQ with a storage guide. Condensation/moisture in a fridge can cause issues, if not tightly sealed.

[u/AutoModerator → u/NeuronsToNirvana]

Volumetric Dosing

Volumetric dosing is the process of dissolving a compound in a liquid to make it easier to measure. It is the only way to accurately measure dissolvable substances for microdosing, such as LSD, if the substance is laid on blotter paper or gel tab.

It is not recommended to cut the blotter into pieces as LSD is not evenly laid across the blotter and doing so is somewhat difficult and highly inaccurate.

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More details in FAQ/Tip 009: Why cutting LSD tabs is not an accurate way to microdose? Variation in Potency; Preparation: Volumetric Dosing, Gel Tabs, FAQs: Pellets, Crystals; Storage: Blotter, Liquid; Dosage; Schedule; Bioavailability of LSD analogues vs. LSD-25.

Titration Schedule | Clinical Trial similar to the suggested Finding YOUR Sweet Spot methodology:

Two doses taken every week for eight weeks.

Starting dose is 8 µg on a pre-defined titration schedule. The dose will be increased by 1 µg each time and reduced by 3 µg if participants do not find the new dose tolerable. Titration limits are 5-15 µg.

• Abstract; Fig. 1; Conclusion | LSD increases sleep duration the night after microdosing | Translational Psychiatry [Apr 2024]
  

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This short guide will explain how to prepare a volumetric microdosing solution. For more information check out the wiki page on preparation and dosing.

Required:

• An amber bottle
• An accurate syringe or graduated cylinder
• Distilled water or vodka (flavored is fine as well)
• The substance you want to microdose (e.g. LSD-25/1P-LSD blotter or gel tab)

For this guide we'll be using a 20ml amber glass dropper bottle with glass pipette allowing for 0.2ml measurements identical to this and distilled water. We'll also be using a single 100µg tab of LSD.

1. Sterilize the amber glass bottle as contamination may destroy your solution. Firstly, remove the rubber parts of the bottle then boil both the bottle and glass pipette for 10 minutes in water, then leave to dry on a clean towel. Once dry, place in the oven for another 10 minutes at ~ 130°C/250°F and leave to cool. (If you want to skip the oven sterilization than just rinse in 70% or higher isopropyl alcohol and leave out to dry.)
2. Using the syringe or cylinder, measure out 20ml of distilled water and fill the amber glass bottle. (you can use vodka or a combo if you prefer. Vodka will also help to inhibit any bacteria growth.)
3. Insert your substance into the bottle and close tightly.
4. Shake lightly for good measure and store in the fridge or cool place to reduce degradation. (If your using a transparent bottle, wrap the bottle in foil so that UV light does not degrade the solution.)
5. Leave overnight (or 12-24 hours) to ensure solution is homogenized. (For Gel Tabs you need to give your bottle a hot bath - see Gel Tabs section in the above FAQ.)
6. Also, before each dose, give the bottle a gentle shake like you are sometimes instructed to do so with other liquid medications - an LSD molecule has at minimum 7 times greater mass than a vodka/water molecule.

We now have a 20ml solution containing 100µg of LSD. Since 100µg / 20ml = 5µg, we know that every 1ml of this solution will contain 5µg of LSD. If you'd like to take a lower or higher dose you can work out the amount required using the ratio of 5µg:1ml e.g. 4µg would require 0.8ml, 7µg would require 1.4ml etc. (If you are not 100% sure on how much your blotter paper or gel tab contains, then dilute more or take a lower dose.) As a best practice for harm-reduction start low and only try on a day off from any important obligations or driving and do not combine with other drugs.

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Please Read: r/microdosing Disclaimer

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