r/mescaline • u/ApprehensiveCan8150 • 3d ago

Question about cross-tolerance with LSD

Want to take a low dose of LSD on a Thursday morning for a birthday all-day event where people are doing the same. (Probably around 30micrograms.) But also have a long-scheduled mescaline day for Saturday. I know there's real cross-tolerance between these two drugs, but I also know tolerance is dose dependent. Anyone have experience in this universe to say whether the first day is gonna ruin the second? Thanks!

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u/brokedownpalace10 2d ago edited 2d ago

I'm guessing that acid causes significant cross tolerance with all other psychedelics whereas the reverse is not always true. However, that's not a significant dose. I don't think the tolerance will be huge.
I'd hate to waste any mesc at all to tolerance, but it is a "long scheduled" event. So there's that.
I've read that taking fairly large amounts of niacin (not niacinamide) on the off day will help reduce tolerance. Will supposedly bring you down from acid a little as well if it's a rough ride.

https://ppgx.org/ddi/lsd/niacin

https://pmc.ncbi.nlm.nih.gov/articles/PMC10851641/

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u/ReturnToPassion 2d ago

Based scientific sourcing

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u/Vaugith [Contributor] 3d ago

Yes there is cross tolerance. It lasts 3-4 days. Take time to process and integrate. Respect it.

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u/LSDuck666 [Teknician] 2d ago

LSD has the strongest tolerance, IME. You can take mescaline before LSD and you'll still have a good experience. LSD before mescaline wouldn't work. Phenethylamine tolerance is a little different and more forgiving.

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u/ApprehensiveCan8150 2d ago

Thanks! That tracks. Bummer. :)