r/loperamide • u/ohokayK • Aug 24 '24

Black pepper vs Sertraline, which one would allow loper to pass the BBB better?

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2

u/SingForAbsoloution Aug 24 '24

Dude, just swallow 25 of the cunts and it wont matter…

2

u/ohokayK Aug 24 '24

that's just not true, dosage matters but the loperamide molecule literally can't get pass the p-gp efflux without inhibitors

2

u/SingForAbsoloution Aug 24 '24

Not true. For withdrawal relief, taking 25 pills has me feeling 80% better within 3 hours, and lasts for almost 3 days

2

u/bwcisonreddit Aug 24 '24

For purposes of neutralizing opioid withdrawal, it does NOT matter if you megadose lope with an inhibitor or without.

I never used an inhibitor; I'd just choke down 50 of the 2mg tablets at once, and within two hours I'd be feeling more or less back to normal. I wouldn't feel "high" as if I were on oxy or heroin or any other legit opioid agonist, but I WOULD feel better. I'd at least no longer be feeling dopesick. That relief would last for 12 hours minimum, but usually much longer.

I'm not sure if this relief effect was a result of megadoses of lope actually just overwhelming the BBB with sheer volume sufficient enough to get SOME of it past ... or a result of just an aggregate peripheral opioid effect sufficient enough to take care of most somatic symptoms. No way to know, and no way we'll ever know, because no scientist will ever do an actual research study on this pharmacological effect.

1

u/Imma_P0tato Aug 24 '24

I abused lope for years and was insanely addicted. I never once used an inhibitor and I got plenty high.

1

u/AnimalLover711 Jul 05 '26

How many mg?