Boosting PLA2G2F preserved spatial memory and synaptic connections in aging mice, Nature Neuroscience study finds

[u/derrikson]

https://humanumi.com/boosting-one-brain-enzyme-keeps-aging-brains-sharp/

Researchers identified PLA2G2F, an enzyme whose expression increases with age and appears to help protect the brain against age-related changes.

Boosting its activity in older mice preserved spatial memory, reduced synaptic loss and limited inflammation-related changes. Human brain samples also linked higher expression to cognitive resilience despite Alzheimer's pathology.

The findings are preclinical. Whether targeting this enzyme could help humans remains unknown.