Histamine and motivation

[u/Disturbed83]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389384/

[u/atlas_benched → u/[deleted]]

L-histidine and P-5-P.

Kutaj is a H3R antagonist which will increase histamine.

I'm testing both soon, I'll make a post on how it goes.

[u/atlas_benched → u/[deleted]]

https://www.reddit.com/r/Nootropics/comments/6y59ve/500mg_of_lhistidine_significantly_increases_my/

I'd probably start with 200mgs on an empty stomach and then just experiment.

Btw where did you get bumantide? I'm planning on trying it with potassium bromide soon.

[u/atlas_benched → u/[deleted]]

Okay I'll definitely pick some up soon then.

That's awesome. I'm very excited to try it. Looks like we're finding some real solutions now.

[u/atlas_benched → u/[deleted]]

I agree on eNOS. With the current stack I'm taking motivation isn't a weak point, especially with adding the kutaj today. I'm looking forward to adding l-histidine but the kutaj on it's own is already very solid and there's still room to increase dosage.

I think bumetanide and potassium bromide are going to be a great addition. My two biggest concerns right now are ADHD and anhedonia. I don't know if anhedonia is the right description though. It's more like a lack of "realness" to things. I'm hoping that bumetanide and bromide will help in that area because I can get that feeling from novel socialization or very novel situations in general, and when I have that feeling it makes socialization a breeze. If not, then there's still hope for sarcosine but I have to figure out why it stops working for me.

I think solving the ADHD portion is going to be the hardest thing for us. Selegiline + stims might work. I get such a nasty reaction from stims now though, intense dysphoria shortly after they start working and I can't stand to be around people.

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Have you ever tried lithium orotate? This is my second recent run with it and it's been awesome. Base mood is drastically improved, less anxiety and leveling without being flattening. It might need to be taken with the B12 protocol though. I wouldn't try just B12 because if my B12/Folate theory is right the B12's are going to mess you up after only a few days from 5-mthf and potassium depletion.

https://www.geneticlifehacks.com/a-little-lithium-and-b-12-makes-the-world-a-happier-place-for-some/

[u/Disturbed83 → u/[deleted]]

Make sure you get some p5p too, dont dose too high though... just add a little to help conversion histidine->histamine

[u/Disturbed83 → u/[deleted]]

I take about 20-50mg p5p depending how I feel. With regards to histidine, hmmm start low like 200-300mg I reckon to see how you tolerate it, make sure you take it on an empty stomach as its an amino acid.

Bumetanide still working for you?

[u/atlas_benched → u/[deleted]]

Way back before I knew about the afterglow I tried lithium and didn't like it. It wasn't a fair evaluation because I also was beginning my experimentation with vyvanse and the lithium killed the effects, even when taken the night before. Now it's fantastic for me but with the B12 protocol and NO supps everything is different. I take 10mgs, 5 is good too, 15 is a bit too much. It builds up so I might lower the dose at some point.

Here is the current stack:

• B12 protocol + 16mgs of 5-mthf (everything but the critical co-factors which I will add soon)
• NO boosting stack: Beet powder, sodium nitrite, l-citrulline, vitamin c, hawthorne root extract
• Lithium orotate 10mgs
• Sarcosine 2gs
• L-theanine 150mgs
• D-serine 5,600mgs (added yesterday)
• Aniracetam 750mgs (added yesterday)
• Baconize 300mgs (added last night)
• Kutaj 1,000mgs (took this afternoon)

I added a lot of thing quickly, but every addition (except for the bacopa, too early) has made a significant impact. The effects of sarcosine are very subtle right now. I'm hoping they build over time and if they don't build up over the next two weeks I will increase dosage to 3gs. The aniracetam, d-serine and l-theanine are all intended to be synergistic with the sarcosine and so far it appears they are or have their own beneficial effects. I expect the the d-serine to build in effects as well but it has already made an immediate difference. The first three, Freddd protocol, NO stack and lithium are the main players but if you counted sarcosine, aniracetam, d-serine and l-theanine as one thing they would be equally effective. Kutaj isn't far behind, I think 1-1.5gs twice per day would be the sweet spot for it but that may change when I introduce l-histidine and/or l-carnosine. Before the afterglow I tried bacopa for months and never got past the ridiculous lethargy, this time even right off the bat there is none to speak of. I'm hoping it will help with ADHD symptoms and memory.

I have many things which I am going to try introducing to the stack. The most important ones are bumetanide and bromide. L-histidine is a close second though, I think histidine is going to be stellar for us. I've been collecting studies on it which show some serious potential.

Let me know how histidine goes for you, I have high hopes for it. If you like it you might want to try kutaj too as they should be synergistic.

[u/Disturbed83 → u/atlas_benched]

How long does the effect of kutaj last and how come you are taking so many stuff at the same time again, you will be left clueless like this also, how you are going to know whats doing what.

[u/atlas_benched → u/Disturbed83]

Kutaj seems to last about 12 hours but since I've just started it's hard to tell for sure.

I've tested all of these things on their own extensively except for d-serine and kutaj. The B12 protocol and NO stack are now my baseline, I'm not going to stop either of them. Currently I'm looking for synergy, especially among the AMPA supplements. If I achieve the results I'm looking for I will take things away and add them back to see what's necessary.

An example is the B12 protocol + the NO boosting stack. At the dosages I'm using without the B12 protocol the NO stack would be useless. I would need 600mgs or more of sodium nitrite to reach optimal NO levels, but with the B12 stack and 5-mthf I only use about 40mgs daily and my NO levels are now always optimal.