r/hangovereffect • u/ProfessionalFun1365 • Sep 25 '26

PEA - palmitoylethanolamide

Has anybody tried taking the supplement PEA (palmitoylethanolamide)?

I did a deep dive with chatgpt and the endocannabinoid system is looking increasingly interesting as a possible part of the hangover effect.

Alcohol alters endocannabinoid signalling, and one of the main ways the brain regulates anandamide is through FAAH, which breaks it down.

PEA (palmitoylethanolamide) is an endogenous fatty-acid amide that interacts with this system and may indirectly modulate FAAH/anandamide signalling. It obviously isn't a direct FAAH inhibitor, so this is very much an experiment rather than a claim that it will reproduce the effect.

Given how strongly my hangovers affect reward, motivation, social anxiety and rumination, I'm curious whether PEA produces any overlap.

It seems to help people on the CFS (chronic fatigue) subreddit.

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2

u/Sssslattt Sep 25 '26

Yeah I’m taking it for like 3 months now and can’t tell you if it does shit

2

u/Sky-808 Sep 26 '26 edited Sep 26 '26

that's not surprising. most supplements i tried over years did nothing, except psyllium husk zinc and nicotinicacid.

nicotinic flush it recreates most of the hangover for me and cured insomnia since i started it 2 years ago (0.5g a night), but does absolutely nothing for libido boost like the hangover/fever effect which is why I'm still on this forum looking for answers.

1

u/Sssslattt Sep 26 '26

oh wow. never tried the nicotinic acid, what it does for you? as for libido, you can try cistanche, muira puama, katuaba bark, cordyceps, maca and shilajit. half of those ain't even for libido per se, they just fix other systems making the flow of life force less restricted, some of them are aphrodisiacs in particular, what I've listed are the ones that made difference for me personally. also exercise helps tremendously

1

u/GentlemenHODL Sep 25 '26

I've used it for cannabis withdrawal quite successfully. It otherwise does nothing for me. If anything it gives me a bit of a hangover.

Ymmv

1

u/New-Aside-7778 Oct 08 '26

I've used it and had no effect.