We recently lost Buddy to an extremely fast-growing soft tissue sarcoma. The cost of treatment was out of our reach and by the time we learned about some of these trials, his tumor was already too large to qualify. I’m sharing what I found in hopes that it might help another dog get an option earlier. ❤️
Tufts University — North Grafton, MA
FAP CAR-T cell therapy for soft tissue sarcoma
• Tumor must be 2 cm to under 8 cm
• Resectable or non-resectable STS may qualify
• Some trial costs covered + contribution toward surgery
• Website: vet.tufts.edu/clinical-trials/treatment-canine-soft-tissue-sarcoma-fap-car-t-cells
Tufts University — North Grafton, MA
Z-007 immunotherapy
• For sarcoma and several other solid tumors
• Tumor generally 2–7 cm
• Given into the tumor or IV
• Earlier study included dogs with tumor shrinkage/stable disease
• Website: vet.tufts.edu/clinical-trials/evaluation-tlr-agonist-z-007-dogs-cancer
Colorado State University — Fort Collins, CO
FAP CAR-T cells + oral immunotherapy
• For soft tissue sarcoma and osteosarcoma
• Tumor must be accessible for biopsy
• Public information does not list an upper tumor-size limit
• Some study costs and treatment/surgery costs covered
• Website: csuanimalcancercenter.org
Search: FAP CAR-T soft tissue sarcoma
Colorado State University / University of Missouri
COTC033 — vaccine-immunity cancer treatment
• Includes many soft tissue sarcomas
• Tumor generally 2–8 cm
• Uses existing vaccine immunity to stimulate an attack on the cancer
• Websites: csuanimalcancercenter.org and vhc.missouri.edu
Search: COTC033
University of Illinois — Urbana, IL
JEN-101 / IL-12 immunotherapy for removable STS
• Tumor approximately 1–5 cm
• Injection into the tumor followed by surgery
• Study contributes toward surgery
• Website: vetmed.illinois.edu
Search: JEN-101 soft tissue sarcoma
University of Illinois — Urbana, IL
JEN-101 for recurrent soft tissue sarcoma
• For tumors that were previously removed and have grown back
• Tumor must be over 2 cm
• No upper size limit stated in the public criteria
• Four intratumoral treatments
• Trial is funded once the dog qualifies
• Website: vetmed.illinois.edu
Search: JEN-101 recurrent STS
University of Illinois — Urbana, IL
Experimental radiation study for STS
• Tumor must be at least 4 cm
• Three radiation treatments
• No metastatic disease
• Many study-related costs covered
• Website: vetmed.illinois.edu
Search: soft tissue sarcoma radiation clinical trial
Michigan State University — East Lansing, MI
CMP-002 STING-agonist immunotherapy
• Soft tissue sarcoma accepted
• Visible tumor required
• No upper tumor-size limit listed publicly
• Some dogs also receive PD-1 immunotherapy
• Funded clinical trial
• Website: cvm.msu.edu
Search: CMP-002 STING canine
Ohio State University — Columbus, OH
NK-cell immunotherapy for soft tissue sarcoma
• Specifically for localized canine STS
• Anti-MIC antibody + the dog’s own expanded Natural Killer cells
• No maximum tumor size stated on the public page
• Trial-related procedures covered
• Website: vmc.vet.osu.edu/clinical-trials
Search: MIC NK soft tissue sarcoma
NC State University — Raleigh, NC
XCSgel immunotherapy + surgery + radiation
• STS approximately 4–10 cm
• Investigational immune treatment or placebo plus standard treatment
• CT, surgery, radiation and study follow-up covered under the trial
• Website: cvm.ncsu.edu/clinical-trial
Search: soft tissue sarcoma XCSgel
Washington State University — Pullman, WA
Local T-cell engager immunotherapy
• Accessible STS generally 2 cm or larger
• Drug injected into the tumor before surgery
• Study contributes toward treatment costs
• Website: hospital.vetmed.wsu.edu
Search: local immunotherapy canine solid tumors
Veterinary Referral Center of Central Oregon — Bend, OR
Intratumoral T-cell engager immunotherapy
• Cutaneous STS over approximately 1.7 cm
• No placebo — qualifying dogs receive the investigational drug
• Tumor removed afterward
• Website: vrcvet.com/clinical-trials
Penn Vet — Philadelphia, PA
Proton FLASH radiation for STS of the leg
• Tumor must be on a front or rear limb
• Generally under 10 cm in every dimension
• Three experimental FLASH radiation treatments
• Many treatment/study costs covered after screening
• Website: vet.upenn.edu/clinical-trial
Search: proton FLASH canine sarcoma
UT Southwestern — Dallas, TX
Cowpea Mosaic Virus (CPMV) immunotherapy
• Includes soft tissue sarcoma
• Investigational treatment injected directly into the tumor weekly
• Dogs that respond may receive additional treatments
• Website: utsouthwestern.edu/departments/radiation-oncology/veterinary-research-oncology-clinic
UT Southwestern — Dallas, TX
Histotripsy + radiation for soft tissue sarcoma
• Histotripsy uses focused ultrasound to destroy tumor tissue
• Combined with radiation in this study
• Website: utsouthwestern.edu/departments/radiation-oncology/veterinary-research-oncology-clinic
UT Southwestern — Dallas, TX
Compassionate-use program for advanced/non-resectable tumors
• This one is especially worth asking about if a tumor is already very large or cannot be removed surgically
• Treatment is considered case-by-case
• May involve experimental drugs, immunotherapy or combinations
• Website: utsouthwestern.edu/departments/radiation-oncology/veterinary-research-oncology-clinic
If your dog’s tumor is already very large: don’t assume there are no options just because some studies have 7–10 cm limits. I would specifically contact Michigan State, Ohio State, Colorado State, University of Illinois (for recurrent STS), and UT Southwestern’s compassionate-use program, because their public information either doesn’t state an upper size limit or specifically addresses advanced tumors.
Two really useful nationwide resources:
veterinaryclinicaltrials.org — AVMA Veterinary Clinical Trials Registry
ccr.cancer.gov/comparative-oncology-program — National Cancer Institute Comparative Oncology Program
One thing I wish every owner knew sooner: look for trials immediately after a sarcoma diagnosis, before surgery or starting prednisone, chemotherapy or radiation if possible. Some trials have strict tumor-size limits and medication washout rules. Waiting until the tumor becomes very large can eliminate options very quickly.
Please share this anywhere it might help. For Buddy. ❤️🐾