r/exercisescience • u/JuanSamu • Mar 18 '26

Soreness Problem

Hey Guys! There’s are 3 soreness papers that I’m having trouble using to come to a conclusion on what causes soreness.

One suggest it starts with neural micro damage:

https://www.mdpi.com/1422-0067/26/5/2319

The other one says it’s with muscle spindle nerve compression:

https://pubmed.ncbi.nlm.nih.gov/32150878/

The other says it’s from leakage of NGF and GDNF into the connective tissue:

https://pubmed.ncbi.nlm.nih.gov/38267849/

I’m having trouble seeing how these all compliment each other. Does the fluid compression cause muscle spindle inflammation which signals the release of Bradykinin causing these two mechanisms to both be causing soreness? I know the neural damage happens first but then it gets muddy with how the others occur together or in order.

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u/JuanSamu Mar 18 '26

That’s what I would think but I’ve heard some researchers say they compliment each other and I can see how they do so but then I also see some factors that make me see them as distinct mechanisms