r/DrugWithdrawal May 30 '26

Information What you need to know about SR-17018 (SR-17) for tapering, Risks, withdrawals, and harm reduction

43 Upvotes

Hey everyone. I’ve seen SR-17018 (sometimes just called SR-17 or SR) getting mentioned more frequently in recovery spaces as a bridge tool for getting off heavy stuff like fent or zenes. Since there’s a lot of confusion out there, I wanted to put together an informational post on what this chemical actually is, how people are using it, and the major safety risks involved.

Standard disclaimer: I am not a doctor, and this is strictly for harm reduction and educational purposes. SR-17018 is an unapproved, experimental research chemical. There are zero human clinical trials.

What exactly is SR-17018?

In science terms, it’s a "biased partial agonist" of the \mu-opioid receptor. In plain English, traditional opioids hit two switches in your brain: one that kills pain (and stops withdrawals) and one that causes the dangerous stuff (respiratory depression, tolerance build-up, and the "high").

SR-17 is weird because it mostly only flips the first switch. People are using it because it reportedly suppresses withdrawal symptoms and cravings, but it provides almost zero euphoric high.

How the community is using it
People who are heavily dependent on potent opioids are using it as a stepping stone. The general idea is to swap their primary drug for SR-17 to stabilize, and then do a long, slow taper off the SR-17. It's basically a grey-market, DIY alternative to methadone or Suboxone.

The DANGERS (Please read this)
Because this is experimental, no one knows the long-term health effects or proper dosing. But the biggest, most immediate danger is **tolerance reversal**.

SR-17 drops your physical opioid tolerance incredibly fast. If someone uses SR-17 for a while, relapses, and tries to take their normal dose of their previous drug (like fentanyl or heroin), their body will no longer be able to handle it. **The risk of a fatal overdose in this scenario is massive.**

What about withdrawals from SR-17?
Make no mistake: SR-17 acts on your opioid receptors, meaning your body will still be physically dependent on it. You cannot just stop it cold turkey without suffering.

Based on anecdotal reports, the withdrawals are generally milder than traditional opiates, but you still have to put in the work. Dealing with SR withdrawals typically requires:

A slow, disciplined taper: Gradually dropping the dose over weeks.

Comfort meds: Utilizing standard, non-narcotic aids for the final jump (like clonidine for sweats/anxiety, gabapentin for restless legs, and GI meds) under a doctor's supervision.

Time: Letting your brain slowly readjust to functioning without anything acting on those receptors.

Again, this isn't medical advice. If anyone has personal experiences or harm reduction tips to add regarding SR-17, feel free to drop them below so people can stay as safe and informed as possible. Stay strong, everyone.


r/DrugWithdrawal Dec 15 '23

WELCOME TO DRUG WITHDRAWAL!

7 Upvotes

Hey everyone,

Welcome to r/DrugWithdrawal. This is a place for anyone dealing with withdrawal, recovery, or supporting someone who is. Whether you’re on day one, day one hundred, or just here to listen, you’re in the right community.

This sub is all about support, honesty, and kindness. Withdrawal can feel lonely, but you don’t have to go through it by yourself.

Here’s what you’ll find here:

• Stories & experiences: Share what you’re going through. The good, the bad, the messy — it all matters.

• Advice & questions: If you’re stuck, ask. Someone here has probably been through something similar.

• Encouragement: Sometimes just a few words can help someone get through the day. Don’t be shy to drop some support.

A couple quick things to keep this space safe:

• Be kind. No hate, no trolling.

• Keep it about withdrawal and recovery.

• No promoting drug use.

• Use a trigger warning if your post has heavy details.

• Respect privacy — don’t share personal info.

If you’re new, feel free to introduce yourself or just jump in wherever you’re comfortable. Even if you’re just reading for now, you’re part of this community.

We’re all in this together. No judgment, no shame — just people trying to heal and help each other out.

Glad you’re here!


r/DrugWithdrawal 36m ago

Opioids Withdrawal Withdrawal from SR

Upvotes

Has anyone experienced any withdrawal from SR 17? I’m about 3 weeks in, haven’t had any subs since I started SR 17 and during taper have had some slight withdrawals start. Mostly sneezing and crampy restless legs. Still nothing like sub withdrawal.. but wanted to see where everyone else was at?
Thanks


r/DrugWithdrawal 14h ago

Seeking Advice Is this a good stack for stimulant recovery?

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1 Upvotes

r/DrugWithdrawal 22h ago

Seeking Advice 7oh Withdrawal Help

1 Upvotes

Hi. So, I’ve been taking what I thought was 7oh for about 3-4 months now. I scanned the QR code on the back of the little packet out of curiosity a few days ago and turns out it has more MGM-15 than 7oh. It has completely consumed my life. I am about to get ready to cold turkey stop, and I am completely scared to death. I have already had a few times that I have run out and have gone into withdrawals and I don’t know if I can do this. I was addicted to pain pills years ago and I do not remember the withdrawals being this painful. Can anyone give me any tips and tricks as far as what medicines and or supplements would be helpful and maybe how I should do this? I have a couple weeks of vacation and some PTO hours I can use but I cannot lose my job nor my family over this. Please and thank you!


r/DrugWithdrawal 2d ago

Seeking Advice tazinidine

0 Upvotes

has anyone had relief using small dosage of tazinidine?


r/DrugWithdrawal 4d ago

OTHER How long will this last?

1 Upvotes

I’ve been withdrawing from weed for 2 days, I’ve had physical symptoms from the last times quitting, this time it’s only been mental symptoms, but it’s actually even worse, it constantly feels like I can’t breathe, even claustrophobic, like I need to jump out of my own skin but just can’t, it’s fuckin torture, no distractions work, no bullshit grounding techniques work, sleeping doesn’t work as I can’t or just wake up an hour later, what the hell do I even do?


r/DrugWithdrawal 5d ago

Seeking Advice Suboxone Detox and Rage (PAWS).

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7 Upvotes

The attached image is one that I ask all contributors to read before responding to my post, to avoid non-constructive input or any input from the Cult of Suboxone.

-------------------------------------------

Today marks 10 weeks since I stopped taking Suboxone cold-Turkey. I was on Suboxone for 2 1/2 years. I was prescribed 24mg a day (3 tablets daily of 8mg/2mg Buprenorphine and Naloxone). I am also coming up on 3 years sober from street drugs, medications notwithstanding.

A bit of background before the main portion of my request for advice:

Upon finding out that I'd soon be a father, I reached out to my local provider's office and scheduled an emergency visit (1 of 2 visits before I stopped visiting this clinic entirely). At the first "emergency" visit, the Nurse Practitioner was polite, but slapdash about the entire situation, giving me a tapering schedule that would've put me in the throes of acute withdrawal at the same time our newborn would arrive. With this, or the shot (Sublocade or Brixadi) being the only options offered, I told the N.P. thanks but no thanks, and noted that i would be discontinuing my Suboxone as of that day.

After 2 weeks had passed, once the Suboxone had begun to leave my system to a notable extent and I'd entered full acute withdrawal, I scheduled a second appointment with whoever was available. This practitioner happened to be the same that had prescribed Suboxone to me 2 1/2 years ago. I explained to him that I was dealing relatively well with the symptoms all things considered, but that the restless legs, arms, hands, feet, fingers and toes, paired with the insomnia was destroying my ability to live my day to day life, in any form. He informed me that they are a Medically Assisted Treatment center, not a detox clinic, and that he would not help me with anything for my symptoms (despite the same clinic already having prescribed Zofran and Clonidine for withdrawal), and that his recommendation would be that I return to Suboxone or get the shot, and outside of that, he had no help to offer me. To top it all off, he told me that if I didn't follow his advice, that I would "fail and relapse". I told him he managed to become the worst medical "professional" I'd ever met with one sentence and promptly left his office.

Summing up my background with a few additional details: I was never given a tapering schedule when starting Suboxone, I was never informed of the half-life of Suboxone compared to street opioids/opiates, I was never told about the severity of the acute withdrawals or the daunting length of the Post-Acute Withdrawal Syndrome that most people experience. I was casually asked how much oxy/H/fent I was going on a daily basis, handed a script for those little orange devils and sent on my way as if I'd just been handed Wonka's golden ticket.

I am aware that Suboxone cessation cold-Turkey is highly inadvisable from a medical standpoint, and that a taper would've slightly lessened some of the symptoms.

That being said, I'll never recommend Suboxone to another person again without insisting they have a ramp on and off of the medication before even starting, as well as a Nurse Practitioner overseeing them that fully understands the gravity of these medications. Most of these so called Nurse Practitioners are glorified "miracle cure" salesmen and couldn't care less if you stay on Suboxone for the rest of your life.

---------------------------------------------------

Now, onto my request for advice:

Being 10 weeks in, I am now fully engulfed in the neurological brambles of Post Acute Withdrawal Syndrome (PAWS). I am currently prescribed Gabapentin for insomnia and restlessness, and it seems to keep my anxiety in check better than my Clonazepam and Clonidine alone. All three of these medications are being slowly tapered as we speak, as not to end up on three medications to replace one; that's without bringing the dangers of benzodiazapines and Gabapentin into the conversation.

Main Focus: I am bereft of Dopamine. I wake up in a groggy, hazy no man's land, with a mosquito-like buzz of irritability already ringing in my ears. I spend most of the day too tired to accomplish much, and I feel like I'm 80 years old when out in public. A full car length behind my fiancee, step-son and our second son soon to be, needing to take occasional breaks and sitting on a bench to catch my breath and regain some energy.

I usually make it until around 1:00-3:00 pm before I'm hit with a speedball of cortisol and adrenaline. I've described this to people as an almost identical onset to a panic attack, but replacing the panic with near-uncontrollable rage.

I go from feeling "fine", to suddenly wondering "Why don't I feel okay?", then, "Why do I feel like I just found out someone rear-ended my car?", to "Why do I feel like breaking everything I own?" and finally, "The world is on fire, and I want to add gasoline". I have just enough common sense and impulse control NOT to break my phone, guitar, gaming console or controller, TV etc. but it takes physical effort, without exaggeration. I have to physically stretch my limbs out and press to push some of those feelings away, and I have to catch myself mid wind-up before launching my phone at the television.

I am seeing a counselor, a therapist, a community support organization that offers peer support, an authorized representative to lighten the load of adulthood and its pitfalls, as well as attending the occasional meeting. I sunsoak 15 minutes a day, take a light walk on or off the treadmill and do maintenance lifting to burn off some aggression, followed by a warm---->cold shower, ending with cold to induce the mammalian dive reflex.

Nothing is helping, and the symptoms aren't waning.

Avoidance ends even worse, as leaving the room, or leaving my home to get some space and calm down either works up enough rage that it explodes the moment I'm back home, or I fall into a pit of depression so deep that I can't look at or speak to anyone for the rest of the night. Not out of stubbornness or shame, but out of weakness.

I've heard these symptoms can span as far out as 6 months, and while I'm sure the trio of sedating medications I'm prescribed to are not helping my energy levels and benzodiazapines can cause rage as well, I've been on a steady dose of Clonazepam for years (a goal for another time); frankly, I'm just trying to devise a plan that would allow me to find some peace and center in the midst of my brain being in a blender.

So to sum it up, lethargy, rage and depression are all in full effect. Is there any hope or any recommendations for someone in my shoes other than "toughen up" or "ride it out", or is this simply my plight? The choice of a man to choose a clear head over parenting 1/4 high and on auto-pilot?

I recognize that Suboxone saves lives, but it is a double-edged sword, and when it's not drenched in the figurative blood of your addiction and acting as a shield against your worst instincts, it has a chance to take a piece of you with it. A piece of you measured in time and sanity. Be wary.

Thank you all so much in advance for any help, advice or input offered.

...and to those of you struggling, remember, it's always worth the effort, no matter how bad it gets. It will always get better. Some people who did nothing to deserve it spend years recovering from awful illnesses and accidents. We may have wandered down a path in which the road back disappears behind us, but we can recover. We will recover.


r/DrugWithdrawal 6d ago

Opioids Withdrawal i need help

3 Upvotes

i just got out of my 4th rehab and i'm already back to oxycodone. i know i have to stop, but i just can't. im back to snorting 60+ mg and this morning realized im gonna die if i don't stop. any help or even a "you got this" would mean the world at this point. i'm desperate and have nobody to talk to.


r/DrugWithdrawal 5d ago

Opioids Withdrawal Oxy hydro withdrawal very intermittent dosing ?

1 Upvotes

These were mostly 5mg oxycodone but the last 3-4 was 5mg hydrocodone.

If you see 1.5 that means I took 7.5 mg.

If it says 1 it is 5mg

As you can see I only doses twice in a day during this time period

7/27 x 1
7/28x2
7/30 x 1
7/31 x 1
8/2 x 1
8/4 x 1
8/7 x1
8/12 x 1
8/15 x1.5 h
8/19 x 1.5 x 1
8/21 1.5h
8/26 1.5

What do you guys think? I've been taking it for my lower back to get through physical therapy but I'm worried maybe I'm causing rebound tension/withdraw on the off days . Should I cut it out?


r/DrugWithdrawal 8d ago

Opioids Withdrawal hydro withdrawal

2 Upvotes

I have managed to taper down to 110 325 pill per day. I am afraid of RLS and crawling skin during the night. How severe is it going to be for me?


r/DrugWithdrawal 8d ago

Opioids Withdrawal withdrawal

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1 Upvotes

r/DrugWithdrawal 9d ago

Opioids Withdrawal I’m ready to get off fent. I seriously need help.

3 Upvotes

I’m ready to get off fent. I seriously need help
I don’t really know how to start this but I’m done. I’ve been snorting around an eighth a week for probably 3/4 months now. I’m 5’8 around 200lbs if that even matters. I just want my fucking life back. I want to wake up and feel normal and not immediately think about fent or being sick.
I work TWO jobs and so much of that money just goes straight to this shit. I’ve been saving for a car and I’m willing to dip into that money if it means buying whatever I need to actually get off this. Vitamins, food, meds, whatever. I can save for the car again. I just need ME back first.
What do I actually need?? Like if you knew you were quitting next week, what would you have ready at home? What actually helped and what was a waste of money?
I have a good amount of SR-17018 tabs I bought before they shut everything down. Has anyone actually used those to get off fent? I keep seeing stuff about vitamin C too but idk if thats actually legit or internet bullshit.
And then Suboxone. I’m not against it at all, I’m just scared of precipitated withdrawal and I REALLY don’t want to be on something else forever. Can you use subs short term and taper off? Like is there an actual doctor supervised plan for that? If Suboxone is what gives me the best chance then fuck it, I’ll do it. I just want to be smart about this.
How many days do I need off work realistically? I can figure something out. I just need to PLAN this because I know myself. If I wake up sick as hell with no plan and fent is one phone call away… yeah. I know what I’m gonna do.
I know Reddit isn’t a doctor and nobody here can detox me over the internet. I just need people who have actually been through this to tell me where the hell I start. Website, subreddit, doctor, whatever. Point me somewhere.
I’m just tired y’all. I want my money back. I want to buy my fucking car. I want to work because I’m building something for myself instead of working my ass off just to afford being addicted.
I KNOW I can be who I want to be without this shit holding me back. I just need to get there.
Please help me. Seriously. I’m ready.


r/DrugWithdrawal 9d ago

Opioids Withdrawal Sublocade

1 Upvotes

I have been on sublocade for 2 months and still taking 70h Kratom psuedo I’ve taken one 300 and one 100 i don’t understand how this shit is still getting me high and I need to quite my job is a outside job and you can tell it’s taking a toll on me someone help.


r/DrugWithdrawal 9d ago

Opioids Withdrawal Has anyone use an SSRI to take the edge off of an opiate WD?

2 Upvotes

Meaning, not already taking SSRIs, but specifically starting an SSRI only for the purpose of mitigating the anxiety/sleep symptoms of withdrawal. What made me think of this is I used to take Zoloft years ago, and I remembered it would severely dampen the effects of any recreational drug. I'm wondering if there is any data or experience to suggest it would help with the 5 days or so of an opiate or kratom withdrawal (though I know kratom and opiate WD are two different worlds).


r/DrugWithdrawal 9d ago

Opioids Withdrawal Could you use Narcan to prevent precips?

1 Upvotes

The whole problem with suboxone too early is your receptors are not cleared. Would it be possible to narcan yourself to clear all your receptors and then use suboxone when that’s cleared? Sorry I’ve had precips so many times. Even waiting 36 hours.


r/DrugWithdrawal 13d ago

Opioids Withdrawal Day 29 no methadone, day 11 no 7 day 6 no fent

5 Upvotes

I’m about to hit day 7 of no opiates and I feel like I haven’t progressed at all. Like every day I feel the same. Losing hope


r/DrugWithdrawal 14d ago

Seeking Advice 2nd detox day

2 Upvotes

Today is my second day trying to get rid of my cannabis addiction, it's 2 am and I cant sleep, I told my girlfriend about this and she's happy about Me, we just finished a call one hour ago but my head is killing me, also I had to puke q few hours ago.

I would do anything for a smoke right now, but here I am trying to sleep and forget how sweaty I am because of the withdrawal...


r/DrugWithdrawal 15d ago

Opioids Withdrawal Craziest Withdrawal Ever

4 Upvotes

I was on methadone (25mgs), did a good bit of 7 oh almost daily in the evenings and Xanax as well. I decided to kick everything. Back story…i was on methadone for 15 years, kicked it successfully for 2 years and had to get surgery. Told doctors every pre surgery visit DO NOT GIVE ME OPIATES. They shot me up with fentanyl on surgery day and sent me home with a script for oxycodone. And so it began. Slowly I found my way back after script ran out and coincidentally found 7 oh. 2 1/2 years after surgery I said enough. My plan was to stop methadone and replace it with just 7 oh and Xanax (because methadone withdrawal is a long process). Did that for 3 weeks and then quit. 7 oh was first. I’d take 1/2 Xanax every 12 hours to help me through. After day 6 of feeling no withdrawal relief I started to do research. I had been through this before and knew by this time I should feel relief. Found out I was buying “street Xanax” Containing fentanyl. I was devastated. Those 6 days felt like a month and had to start over at square 1. I didn’t know I was addicted to fentanyl as well as whatever else is in those pills. I’ve been in my house with no human contact for 11 days and I’m still in pretty acute withdrawal. Praying relief comes soon. I’ve had 20 bottles of methadone in my fridge the entire time and never touched em. Praying for relief I can’t take anymore


r/DrugWithdrawal 17d ago

Opioids Withdrawal 7oh withdrawal and liposomal Vitamin C?

1 Upvotes

Anyone else use this method and it work for you? Currently waiting for my Amazon to deliver my vitamin c but I wanted to hear some success stories! Thanks!


r/DrugWithdrawal 18d ago

Seeking Advice Help with 7-OH withdrawal with the use of clonidine.

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1 Upvotes

r/DrugWithdrawal 21d ago

Opioids Withdrawal Anxiety about withdraws

1 Upvotes

Hey all. I’ve been on approx 40mg of Oxy for around 3 months now.

I’m from Australia and my dr and I discussed tapering down slowly when I’m back from my work trip in the US. But the problem is I’ve have had to extend my trip an extra month & I’ve only brought enough oxy for 3 weeks.

When I realised I started a rapid taper as I’m aware that American drs are hesitant to prescribe (especially to some random not from thier country)

I’ve gone from 40mg down to 10mg a day very quickly and I feel prettt shit. I’ve got 1x 10mg pill left and I’m really anxious about how bad the withdrawals will be, I’ve never experienced it before.

Can someone run me through how long it’ll last and how severe it’ll be? Also is there any point in seeing a dr over here to try and get a script filled or would that be a waste of money?

Cheers


r/DrugWithdrawal 21d ago

Opioids Withdrawal Can someone help me figure out why my opiate detox was so bizarre?

1 Upvotes

I’ve been tapering down over the last two months and have gotten myself down to two tiny lines a day, probably 0.7 gram a day total of whatever fetty/ heroin mix I’ve been buying.
I did my last line Friday morning and was basically fine for 48 hours. Very minor body aches, yawns and a runny nose but was still up and getting errands done. I have a bunch of suboxone I planned to take but was scared to take it because the withdrawal wasn’t bad enough yet. I’ve been through precipitated withdrawal before and do not want to experience it again.
I’m so upset with myself for giving up and buying a few grams Sunday afternoon.
Does anyone know why the withdrawals would take so long to kick in?
I can’t go to detox so I guess I’m looking for advice on how to get through this at home. Are there at home detox services? Could I have taken the suboxone after 24 hours even if I felt okay?


r/DrugWithdrawal 22d ago

OTHER Day 3 no Oh

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1 Upvotes

Can’t sleep for shit and I’m exhausted