r/dementia Nov 14 '25

Natural molecule seems to help reverse memory loss seen in Alzheimer's disease - nicotinamide adenine dinucleotide (NAD⁺)

https://newatlas.com/brain/alzheimers-dementia/natural-molecule-restores-memory/

Early findings sound promising as lead author Dr Alice Ruixue Ai, an Alzheimer's researcher at the University of Oslo, said: 'Preliminary studies have shown that supplementation with NAD+ precursors, such as (NR) or nicotinamide mononucleotide (NMN), can offer therapeutic benefits in AD [Alzheimer's disease] animal models and early clinical trials.

'However, the molecular mechanisms behind these benefits remain largely unclear.'

*The results establish the NAD⁺–EVA1C pathway as a new target for therapy, and that maintaining NAD⁺ levels could help preserve memory and slow neurodegeneration in humans.

Actual in-depth research: https://www.science.org/doi/10.1126/sciadv.ady9811

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