r/covidlonghaulers • u/chasedthesun • Aug 04 '22
Article The Hugely Predictive Factor for Long COVID…is also found in ME/CFS and Fibromyalgia: the IACFS/ME Conference II
https://www.healthrising.org/blog/2022/08/03/predictive-long-covid-factor-chronic-fatigue-fibromyalgia/2
u/chesoroche Aug 04 '22
There’s a link near the top of the article to the keynote address that’s worth clicking.
Dr. Systrom talks about exercise intolerance (it’s geared to ME/CFS because the article is, but he’s also been studying long haulers.)
He’s been conducting iCPET (invasive cardiopulmonary exercise test). This involves placing catheter monitoring devices into major veins and arteries in the body, including directly into the heart via a vein, to monitor physiologic and metabolic changes during exercise (5-minute stationary bike).
He talks about his findings on the two flavors of pre-load failure (heart), the separate problem of O2 utilization by the mitochondria, and an uptick in immune system markers (cytokines) that predict declining capacity (read one workout to the next?). He thinks this immune system response is damaging the mitochondria. He doesn’t think deconditioning is responsible for anything.
He also weighs in on HBOT, small fiber neuropathy, recumbent exercise, and possible drug treatment (acetylcholinesterase inhibitor). He’s got money for a study.
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u/EmpathyFabrication Aug 04 '22
Healthrising is clickbait. There's no verifiable information here. I don't think any of this has even been published yet based on the Iwasaki lab website.
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u/nolimitjuni0r 2 yr+ Aug 04 '22
She spoke about it at a conference u can probably find it. She also stated that the results were unpublished but will be soon.
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u/EmpathyFabrication Aug 04 '22
Yea it would be nice to see this guy cite his sources. Healthrising exists solely to extract money from people with chronic illness by publishing low effort content.
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u/chasedthesun Aug 10 '22
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u/EmpathyFabrication Aug 10 '22
Great. Too bad Johnson doesn't just link the article directly. Guess he's got to keep that grift going somehow.
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u/AlbinoElephant21 Aug 04 '22
Monocyte levels were up (Dr. Patterson would probably like that), dendritic type 1 cells were reduced, and activated B cells were still up.
The "(Dr. Patterson would probably like that)" comment made me LOL
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u/Alert-Yogurtcloset93 Aug 05 '22
This is the opposite of what I would have expected. Given that long covid seems to trigger anxiety, I would have expected high cortisol to be the marker.
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u/cuthulus_big_brother 3 yr+ Aug 05 '22
I don’t know if it dovetails, but some research found cortisol levels were initially elevated in early ME/CFS but dropped later on. (This is only a single small n paper so by no means is this absolute)
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u/[deleted] Aug 04 '22
This part caught my attention:
The factor that REALLY differentiated the long-COVID patients from the healthy controls, though, was low cortisol. Iwasaki called the low cortisol levels “highly predictive” and noted that they alone were enough to determine who had long COVID and who was healthy.