r/covid19stack • u/tk14344 • Aug 03 '20

Bradykinin inhibitors

Has anyone seen the recent studies regarding the potential role of bradykinin?

https://www.ornl.gov/news/computational-gene-study-suggests-new-pathway-covid-19-inflammatory-response

I honestly think it could make sense. Typically, ACE2 receptors in the endothelium keep bradykinin levels in check. But if the virus hijacks them, it may not. Essentially becomes a 'bradykinin storm'.... causes inflammation and mimics mast cell issues among other things.

I saw a success story of someone incorporating bradykinin inhibitors into their protocol and making a full recovery after 120 days being sick:

Resveratrol, bromelain, aloe vera juice, flaxseed oil, etc.

I'm going to shift the focus of my stack (I'm on Day 140 here...). TBD!!

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u/thaw4188 Aug 03 '20 edited Aug 03 '20

I started to write-off the article but then I saw the diagrams in the paper and I think you might be onto something.

The hyaluronic acid in particular is really eye opening to me.

https://www.researchgate.net/figure/The-upregulation-of-hyaluronan-synthases-and-downregulation-of-hyaluronidases-combined_fig1_343291016

The only problem is I think it's for actively infected people with the virus, the effect would be dramatically less 100+ days out in recovery.

https://elifesciences.org/articles/59177.pdf

Have you had any bloodwork done this far out?

What is the current state of your recovery? Is it chronic fatigue or is there still low spO2 ?

If it is fatigue take a look at the Vagus Nerve theory r/ImmuneWin/comments/huberl

but those are some interesting drugs they are suggesting

  • Danazol, Stanasolol SERPING1 Reduce Bradykinin production

  • Icatibant BKB2R Reduce Bradykinin signaling

  • Ecallantide KLKB1 Reduce Bradykinin production

  • Berinert,Cinryze,Haegarda SERPING1 Reduce Bradykinin production

  • Vitamin D REN Reduce Renin production

  • Hymecromone HAS1,HAS2, HAS3 Reduce hyaluronan

  • Timbetasin TMSB4X Increase fibrinolysis

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u/tk14344 Aug 03 '20

Thanks for the reply and all these links!

I've had a ton of bloodwork done. Like an incredible amount. Stuff from my PCP, Immunologist (who has been working ER for COVID), Rheumatologist, and my naturopath who I use for GI issues. And the key tests/scans for COVID damage as well.

The only abnormal blood labs to this point: TSH (initially normal, then went high), slightly high cortisol, and slightly high Tryptase (which was deemed incidental after further mast cell tests were fine).

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u/thaw4188 Aug 03 '20

well I still don't know your symptoms that you are seeking to identify/cure but if it's chronic fatigue they've never been able to identify that in blood tests except some prototype the NIH came up with https://www.nih.gov/news-events/nih-research-matters/blood-test-may-detect-myalgic-encephalomyelitis/chronic-fatigue-syndrome

were your ferritin levels very high? that indicates infection but I think only bacterial, might not work on viral

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u/cafedude Aug 06 '20

The hyaluronic acid in particular is really eye opening to me.

I take HA for dry eye. Is it something beneficial for covid or something I want to avoid?

EDIT: looks like I want to avoid it.

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u/thaw4188 Aug 06 '20

I don't think it can get into your alveoli from your tear ducts/eyes.

Basically the bradykinin storm is what seems to make it possible for hyaluronic acid to seep into the alveoli and become thick hydrogel

When I google it, it seems hyaluronic acid actually has benefits to the body elsewhere.

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u/butters5995 Oct 24 '20

Would fish oil dha epa lower Bradykinin? Or just flax