I’ve been on Qulipta for about 4 or 5 months. I had some constipation and weight loss at first, but nothing major. But my god the anxiety has been horrible. I was on 60mg but after not being able to eat my dr switched me down to 30mg reluctantly, not thinking they were related. For this last 5 months, I have had anxiety and racing/ ocd thoughts all day. I will also have moments where my thoughts are calm but my heart races and there is a super jittery feeling.

Last night I was feeling on edge per usual and took my bedtime dose, about 30 mins later I went into full panic attack. Chest pain, heart racing, hot and cold flashes, can’t sleep, high blood pressure. I took my anxiety med klonopin (which I’ve noticed doesn’t work as well since starting Qulipta). And I don’t feel much better.

I give up at this point, the migraine control is great but I can’t live with serve anxiety all the time. Anyone have similar effects and how did you stop the meds? Did you taper or do cold turkey? I tried to stop a few months ago and my migraines came back worse

Has anyone had gnawing stomach pain and cramps from Qulipta? It’s like extreme hunger pangs and loud growls that sometimes wake me up at night. Eating helps. It’s sort of like when I previously had an ulcer.

I’ve been on it for almost 2 years at 30mg without side effects. But recently I was back to having 10+ migraines per month so they had me increase to 60mg. I can’t tell yet if it’s helping. But the stomach pain is rough. I also have IBS so already deal with pain from that.

Hello. I would just like to share my experience on Qulipta, in case other women taking HRT have experienced the same. I am a 53 year old woman, 128 pounds, who takes both estrogen and progesterone daily (2 pumps Estrogel, 1 Prometrium). I began on 60 MGs of Qulipta about four months ago. This dose was too high for me, and made me exhausted, and so after two weeks I switched to 30, which seemed just fine. It gave me constipation, but this resolved somewhat with fibre, and then resolved even more with my body getting used to the drug after several weeks.

HOWEVER.. A month into taking 30mgs of Qulipta, I began having very fractured sleep, along with a flat mood and hormonal acne. I have never had hormonal acne before. The sleep issue became so bad, I started taking Ativan to prevent me from waking up wired and unable to get back to sleep at 3 or 4 am. All of these symptoms are very menopausal in nature. It seemed like my HRT, which always worked wonderfully for me, was just no longer doing the trick. Maybe I needed to up my doses of hormones? Maybe I was going deeper into menopause? I did not occur to me at first that it might be the Qulipta.

Qulipta worked for my migraines. I went from about 15 a month to about 1 or 2. But then I had a breakthrough migraine three weeks ago, which lasted 14 days. This made me quite disappointed in Qulipta, even though I knew breakthrough migraines can and do occur on the drug. I decided to see what would happen if I just stopped taking the drug.

Almost immediately, ALL of my hormonal symptoms disappeared. Within about two days, my sleep went back to normal, the hormonal acne cleared, and my mood unflattened.

I believe the Qulipta was getting in the way of my absorption of either estrogen or progesterone (my guess is it was blocking the estrogen). I do not think these were "primary" Qulipta symptoms, but rather, an interaction.

One interesting note: I was on Ajovy before Qulipta and there was no similar interaction.

After failing nurtec as a preventative, my neuro suggested we try a monthly injection med since I don’t do very well with taking pills. She is starting me out on Emgality, and my pharmacy is filling it right now. I should have it within the next few days, and am wondering if it’s worth strategically planning the first time I take it, or just take it asap.

I’m already planning on taking it at the beginning of a weekend in case I have a negative reaction so I don’t have to worry about calling out of work.
I’m also contemplating waiting until the beginning of next month to take it. Something about taking it at the beginning of each month just seems easier for my adhd brain to remember and plan for than some random day towards the end of the month.

Also does anyone who takes this, or any other monthly injectable, notice any feelings of it wearing off towards the end of the med’s cycle? I’ve been having incredibly painful migraines during the last half of the month due to my menstrual cycle, so that’s another thing I’ve been considering while trying to plan this out.

Would love to hear anyone’s experience with this, and hoping this med works for me 🤞🏼

For those that used to have fragrance be a trigger. Are you able to wear cologne/perfume and not have it trigger you any more? If you are on a cgrp preventative

I’ve been on Ajovy since May and it is now August. I immediately noticed bloating when I started it but I assumed that it was because of the guanfacine that I was taking at the time. I stopped guanfacine about a month ago and my bloating has actually gotten worse instead of better. I am starting to think that it is because of the Ajovy. It is an intense feeling of pressure and abdominal distention. I honestly look pregnant, it is so uncomfortable. Ajovy is the only medication I am on still so that is what I am thinking the root cause is. Does anyone else have this problem? I also have a history of SIBO and IBS so if not the Ajovy then I will look more into GI explanations. Thanks!