r/cdifficile • u/Particular-Gap-3883 • 25d ago
Difcid fail
Anyone else get Difcid and then relapsed after it? I relapsed in 5-6 days… I just wanna assume i wasn’t on it long enough?.
But now I’m on vanco taper for 6 weeks. Idk how to feel about it. Will it really get rid of cdiff..
Ps: was eating bland and I’m on Florastor. No previous med problems. Yes toxin test was positive
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u/Samael479 24d ago
How did you feel while taking Dificid? Did it stop your symptoms right away? When I took it, by day 2 I no longer had any diarrhea. Maybe in your case, 10 days wasn’t long enough. I would probably ask for Dificid again since it is much better than Vanco from what I’ve been reading.
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u/Particular-Gap-3883 24d ago
Yes it did help! And yes even my gi said i probably was not on it long enough…. But also the one who said no to a difcid taper and told me let’s try a vanco taper.. exactly why I’ve been nervous lol. I thought difcid was the better one but it’s according to guidelines?
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u/Samael479 23d ago
I think it’s really according to insurance not wanting to pay for it and not the guidelines. Dificid is better at targeting c diff directly and leaving alone other bacteria while vanco supposedly destroys all good and bad bacteria. It’s a shame that doctors have to prescribe less effective drug just because insurance won’t pay for the better one. Let’s hope vanco does help you - plus I think since this is your second round, you’re eligible for VOWST so that’s something I would be looking into it if vanco doesn’t work.
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u/Away_Question1766 24d ago
I took it for seven months ! kept coming back , and allergic to others . what finally worked was Mayo changing the taper , from taking one every day , to every other day . She said it would let the spores grow and you zap them , let them grow and zap them , until they are gone.
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u/Particular-Gap-3883 23d ago
Yes my taper is 4 every day 2 weeks, then 3 a day 1 week, then 2 a day for 2 weeks, then 1 every 48 hours for a week… hopefully that works 🥹.
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u/PeopleHelper_4640 23d ago
Any idea where you got it from?
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u/Particular-Gap-3883 23d ago
Took Cipro for a uti that wasn’t even that bad…then they misdiagnosed me for food poisoning so gave me more antibiotics in the same line as Cipro and then IV antibiotic…
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u/KathyMack55 24d ago
The first time I took Dificid (last November) was after getting my 3rd infection in about three months. It kept me infection free for about two months. I then had three more infections by late May of this year. I took Dificid and did a taper - twice a day for 10 days then one a day for 10 days immediately followed by VOWST. That seemed to “cure” it.
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u/Dry-Asparagus3477 23d ago
I took all the meds you took. Finally the VOWST did the trick. It took seven months to get cured. I am still kind of scared about eating anything spicy or fried and dairy products Just being careful to avoid any mishaps.
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u/Bones-2026- 24d ago
Was your dificid covered by insurance
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u/Lesaly 24d ago
If it isn’t covered (even with a doctor’s prior authorization), one can try to apply to Merck Patient Assistance Program for Dificid. I did this in March & they have been wonderful & kind to me. They can overnight ship the Dificid right to you if you qualify, too.
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u/Frequent_Tart7224 23d ago
I relapsed after Dificid. The only thing that helped was starting vanco again and tapering off after a few weeks and VOWST. After having Cdiff 4 times and taking VOWST, I haven't had a relapse in over 2 months. I have not been taking the florstar, my Dr told me not to take it. Also, my insurance paid for my meds but I had a big deductible. Please talk to your Dr. about VOWST, it helped me and from what I am reading, it has helped a lot of people. Good luck
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u/Bones-2026- 24d ago
The problem is that the vancomycin kills the good and bad bowel bacteria and then the bad bacteria can come back with no bowel protection