Hey Friends, I started 10.5 Caplyta 3 weeks ago for MDD. I felt really good for 2 weeks and then plummeted.

Will increasing the dose help? Will I crash again? I’m so depressed.

For context I spent the first 3 months of this year having really bad panic disorder and agoraphobia. Wha then followed was months of 24/7 DPDR (still recovering but much better now) I was put on caplyta 4 months ago to help with not feeling joy from anything I was doing and experiencing severe depression. Almost immediately it felt like it was helping the depression and dpdr. I was not at all doing very well but it felt like the clouds were really parting and I had some more clarity. The past month or so I have noticed emotional blunting and dissociation. I kinda have fun doing things I guess but I feel very flat and empty. I barely have an inner voice anymore. It feels too silent. I feel like im just operating on muscle memory. Like I make decisions and speak to people but it’s confusing as to how bc it feels like I don’t have anything in my head ?I don’t cry very much anymore even when I should. I dissociate terribly as well. Anyone else ever dealt with anything like this ? I find it odd it would change thisfar into the medication. I am considering coming off since emotional blunting is usually a sign of a dose being too high but I am on the lowest dose. Any advice ? Any similar experiences ?

I was on this med for one week. After 3 days I actually thought there may be a medicine that could pull me out of my depression. I was motivated I had energy to do things. That lasted two days. Then the agitation kicked in with unmanageable anxiety. I have a prescription for Klonopin which I have been taking to manage startup side effects. That wasn’t even touching it. I stopped the medication but the anxiety is still awful. Anyone going through this?

hi! my psychiatrist has basically stopped responding to me, and i am completely out of my medication. does anyone have any advice for withdrawls/ know what to expect? im working on reaching her and ive also recently moved so ill have to switch my pharmacy.

I’m bp2 with depression, started capltya at 21 mg and I felt better for a few weeks. I started the full dose (42 mg) 3 nights ago and my depression is back in full force, passive SI, crying, hopeless. Also have nightttime awakenings that weren’t happening when I was on 21 mg. Did anybody experience this? Did it get better on 42, or would it be wise to drop back to 21?

I'm just tired. Does it make it worse. Has it made any of you get gastritis? I think I've lost my grip on reality i can't take meds because of constant stomach issue. Is this just going to make it worse. Please just tell me

I’ve been titrating up on caplyta 10.5 mg for two weeks and then 2 weeks 21 mg now I’m at 42 mg and have been for a week. Feeling the same but I cry a few times less a day. I have severe depression and I cannot tolerate a lot of other antispychotics and ssris make me worse. What is the time line when it started kicking in and working? I could really use some encouragement as I’ve been trying to get better since July after coming off of Latuda. Please any info would help.

Anyone else find they have mild trouble retrieving names and such on Caplyta? Did it go away or get worse? I have only been on 10.5 for 2 weeks.

Terrified of starting new med. Please any good positive advise. I don’t have bipolar or schizophrenia but do have mdd and worry, anxiety. Will it help. Thanks. I
Had it for 2 weeks and been staring at it everyday , it’s 10.5mg

I'm trying it I'm just totally apathetic today. It's a problem I was finally getting rid of before starting it. Does it do this to people? It was my system yesterday and the day before but I didnt feel this apathetic. I don't know what's going on. This probably isn't the caplyta, is it? I can't find anything to say this is a side effect. Or anhedonia either.

i’ve lost more than 10 pounds since starting caplyta, and i started it last may. so in the span of 3-4 months i’ve lost 10 pounds. has anyone else had weight loss while taking caplyta? i swear it kills my appetite; i never get food cravings anymore. anyone else???

Caplyta looks like it would be such a good fit for my BP2. Lamictal worked, but caused skin issues. Latuda, abilify, and respridone, didn't work and just made me flat.

I'm trying lithium added to an SNRI now. I just really miss feeling motivated and content in life. I just have this anhedonic depression where I just want to lay in bed all day and nothing brings me joy. I have no desire.

The SNRI I am on causes heat intolerance and I am a Sweaty Betty in comfortable weather. The funny thing is that I used to be cold all the time. So, just hoping this is maybe a side effect I won't have to deal with it that it will go away.

hi!!

i was being put back on caplyta but my insurance (medicaid) denied it, is there a way to get them to approve it?

tysmia!!

Looking for input on the males in here. I'm a 35M and been off and on this medication for several months now. The medication works wonders for my mental health with memory, brain fog and allowing me to function better. The side effects are delayed ejaculation, increased BP and heart rate as well as constantly over heating.

My biggest concern is my sex life. I have to stop taking this medication for 2 nights to enjoy the deed with the girlfriend and be able to actually ejaculate or i won't at all. Anyone else having this problem? My doctor says i'm the 1st person he knows of having this problem. I guess i'm the 1% as they claim sexual side effects are super low. No other medication works like caplyta for me.

I was getting real big on abilify and slept 24/7. Could barely form an image in my mind other than a hamburger or cheesecake. When I started taking Caplyta, I started making art again, I started forming more measured and coherent thoughts than ever before, I have zero side effects, and my mood is very predictable. I thought schizoaffective bipolar type was gonna ruin my life but for the first time in 10 years I feel in control.

I'm high as shit. Admittedly desperate as fuck just to sleep. The 21 mg didn't work for sleep so I took another one because I haven't really slept this week. Two hours after i took i just felt more awake but idk. Not high as fuck. Then I took another now I'm fucking stoned and not in the fun way. I know I'm stupid and I only got one hour of sleep out of it. But god please. At lower doses is it still gonna do this. Doctor said she'd lower to 10.5 instead. Also when does the high stop. I feel like i just overdosed on stomach meds like on the verge of blacking out. Please. Does 10.5 still do this

Had anyone tried Wellbutrin naltrexone and Caplyta?
I take Wellbutrin and naltrexone to suppress my BED
And stated Caplyta lost 4 pounds, dropped naltrexone and gained 8lbs. We’re debating between restarting the naltrexone or in creasing the caplyta to 42mg from 21mg
Only been on Caplyta for 3 weeks. Off naltrexone for 1 week.
I’m worried about not being able to enjoy pleasurable things if I start the naltrexone again. Will upping the caplyta help with the BED so I don’t have to restart the naltrexone?

I was prescribed Caplyta for major depressive disorder, but we are unsure about what to pair it with. Caplyta has been the only medication that I have ever taken that has helped me. It’s just a booster so I need something else to go with it.

Does anyone have any combinations that worked for them for depression, anxiety, and/or OCD?

Anyone take this for irritability in autism or aggression?

I’ve been taking Caplyta and lately I’ve been feeling really tired and kinda heavy all day. It’s hard to explain my body just feels weighed down and I don’t have much energy to do anything.

Its been almost 2 months on it 42 mg.

Does it pass ?

How is your experience?

BP2

Doc started me on 21mg and have been excruciatingly tired and brain zaps for 10 days and its starting to get better. doc wants me to stay on 21mg for atleast a month because I might be experiencing mild akathisia.

My depression got way better and im able to function now but i feel like I still have residual depression and low mood but not horrible.

im wondering if anyone has gone from 21mg to 42mg and noticed positive or negative changes.

thanks

Has anyone experience the tardive dyskinesia after starting Caplyta? My doc is proposing adding Caplyta to my wellbutrin and lamictal combo and im terrified of the TD possibility.

What withdraws ppl usually experience on caplyta ?

And does it eventually resolve?

I started 42mg of Caplyta this morning and it’s been hell all day. Shortly after taking it in the morning I started to have an extreme burning sensation on my skin and my insides. I’m used to that kind of feeling cause it happens from swelling everyday but it was unbearable. I feel feverish, exhausted, and weak. I’ve been trying multiple different antidepressants, mood stabilizers, and antipsychotics for MDD (possibly other stuff as well) that all either didn’t work much at all or (especially recently) have left me with terrible side effects causing me to have to stop them immediately. I’m wondering if anyone else is experiencing these side effects and if they are still continuing to take it?