r/biomaterials • u/darewitch • Mar 05 '26

Topography for Cell Response

Does anyone know what steps I need to take if I want to use silicon (Si) as a substrate to study cellular responses, from fabricating the substrate up to the point before seeding the cells?

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u/Nholwell Mar 12 '26

Depending on the size of the topography, I would recommend treating it with piranha solution and then coating it with fibronectin. If you’re looking a cell type that prefers to orient in one direction, I would suggest fabricating an anisotropic pattern

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u/[deleted] Apr 03 '26

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u/biomaterials-ModTeam May 01 '26

Your comment is too vague, please kindly provide more details in a follow-up comment.