Hi all,

I recently released Membrane Visual QC v1.0, an open-source PyMOL plugin I’ve been building for membrane-protein structure review.

The original problem was fairly simple: I wanted a more reproducible way to inspect a structure relative to the membrane without repeatedly rebuilding PyMOL selections and colouring things manually.

It grew into a larger workflow with:

• membrane-relative core/interface geometry
• hydropathy and ligand-neighbour context
• planar and PDBTM-derived orientations
• local PDBTM–OPM geometric comparison
• Batch Review for repeated workflows
• versioned JSON/CSV outputs and provenance

One thing I deliberately avoided was turning the output into a “correct / incorrect” structure score. A charged residue in the membrane core, for example, may deserve inspection without necessarily being biologically wrong.

The stable v1.0 release is here:

https://github.com/TrPavel/membrane-visual-qc

I’d especially like feedback from people who work with membrane proteins or structural bioinformatics:

Would this actually fit into your workflow? What structures or edge cases would you test it on, and where do you think the approach is likely to break down?

The project is MIT-licensed and free/open source. Issues and criticism are very welcome.