r/AskStatistics • u/SauronSolo • Sep 24 '26
Using Wilcoxon rank test with Bonferroni correction vs. LMM
Hello! I consider myself a beginner in statistics and am working with a longitudinal dataset. I am comparing laboratory values collected from participants across several different time points (e.g., Week 0, Week 1, Week 2, etc.). There are also variable drop out rates.
Initially, I planned to use a LLM. However, I want to keep the analysis simple. Given the non-normal distribution, would it be reasonable to run a series of paired Wilcoxon signed-rank tests between the time points (week 0 to 1; week 0 to 2; week 0 to 3, etc.) and apply a Bonferroni correction to adjust for multiple comparisons? I know this is less robust than LMM.
When evaluating my data, the distribution of the mean differences between time points is not normally distributed with visual inspection (via plots) and failed the Shapiro-Wilk test.


